Our work on explaining how excitatory and inhibitory firing rates change after sensory deprivation is now published in #PNAS @PNASNews. One day post visual deprivation inhibitory firing rates in the visual cortex decrease, while excitatory rates stay the same. On the day two,
https://twitter.com/MpiBrain/status/1562076977506537474
inhibitory rates recover, while excitatory rates decrease. Classical inhibition stabilized networks cannot capture this effect because of the paradoxical effect as shown by Tsodyks et al. We add a second class of inhibitory neurons in a cortical network model
and use a generalization of the paradoxical effect to explain the temporally offset changes in inhibitory and excitatory firing rates. The generalized paradoxical effect includes not just multiple inhibitory neuron types, but also plasticity along feedforward & recurrent pathways
The results also apply to firing rate changes in somatosensory cortex where intrinsic plasticity affects the feedforward pathway.
Work by PhD student Leonidas Richter who recently graduated with summa cum laude.
And based on beautiful data by @kbhengen and @TurrigianoLab
• • •
Missing some Tweet in this thread? You can try to
force a refresh
