1. There is only one reason to reduce the isolation period to 5 days. And that is because you want to kill more people, while accelerating spread in the workplace, thus exacerbating worker absenteeism to undermine the economy
2. This self-destructive economic plan based on culling social ballast to set free the economy is #NegativePopulationEconomics unleashed by the architects of annihilation and represents Social Darwinism at its worst
3. Those who have rekindled a neoclassical variant of #NegativePopulationEconomics may not recognise themselves characterised as such, but that is what their macroeconomic principles are tantamount to.

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Keep Current with Dr Satoshi Akima FRACP 『秋間聰』

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More from @ToshiAkima

Aug 29
The paper is now out in @Nature after I tweeted on this oral presentation @ISTH 2023 by @AkassoglouLab. Fibrin/fibrinogen may be a therapeutic target in СОVΙD neuropathology. Link in next tweet.
“...results reveal a role for fibrinogen as a SARS-CoV-2 spike-binding protein accelerating the formation of abnormal clots with increased inflammatory activity”…“fibrin-targeting immunotherapy suppresses SARS-CoV-2 pathogenesis”.

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From an #immunothrombosis perspective, this paper now shows fibrinogen to be a far more critical player in this field than previously thought. We used to focus more on contact, TF, and thrombin but now must look further downstream in the fibrinogenesis/fibrinolysis pathways too.
Read 7 tweets
Aug 5
And this week's Grand Rounds “just a cold” is another young patient with enterovirus-induced fulminant myocarditis needing intubation, ECMO, and an Impella LVAD. I've never seen so many severe post-infectious complications presented in my life.
Last week's Grand Round? Another “just a cold” with Mycoplasma in a paediatric patient who developed encephalopathy, needing IV pulse methylprednisolone and IVIg. It's like every week we see a new case of previously rare infectious complications in young patients.
Another Grand Rounds case. A pregnant woman with severe cardiomyopathy caused by a combined adenovirus and enterovirus infections. Required ECMO.
Read 4 tweets
Aug 3
Subjecting trial subjects to wearing surgical mаsks against an airborne virus is like running a bike helmet RCT with subjects in Tupperware helmets that weren't designed for that purpose. “But we don't know it doesn't work until we run an RCT” isn't good enough.
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“But there was a 30% reduction in head injuries in the Tupperware group vs. placebo.” Not good enough! In a high-risk scenario for major head injury, a Tupperware helmet won't do. The magnitude of risk test subjects were exposed to needs investigation and quantification. Image
Non-pharmaceutical physical protective devices are subject to engineering standards of proof of efficacy. In the case of helmets, that means crash testing in a lab to see how they fare in high-risk situations that live subjects can't be exposed to. helmet.beam.vt.edu/lab.html
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Read 7 tweets
Jul 31
A reminder that there was once a titanic struggle between contagionists vs miasmatists over the mechanism of transmission of cholera before the need to cleanse the water of waterborne pathogens was accepted. We are going through a similar struggle today, fighting for clean air. abc.net.au/news/2024-07-3…
If you want to read about how divisive the debates between the contagionists and miasmatists was, you should read “Death in Hamburg” by @RichardEvans36. They didn't need Twitter back then to be almost reduced to pistols at dawn.
Quoted in the article by @Hayley_Gleeson is our latter-day Professor Pettenkofer from Down Under: “I want to believe…”
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Read 4 tweets
Jul 25
This trial should have been reported as having an unacceptable 70% failure rate, showing that a surgical mаsk is grossly suboptimal in design and not fit for purpose as RPE. Engineered physical protective devices aren't drugs. bmj.com/content/386/bm…
You wouldn't consider a parachute that failed to deploy 70% of the time to be an acceptable design to test by RCT, and neither should droplet protection against an inhaled bioaerosol be considered ethically acceptable for a study design.
Physics permits greater predictability than pharmacology. This RIKEN supercomputer study already predicted the results of the BMJ study. For a loose surgical/non-woven mаsk, there is a 45% infection rate (55% reduction) to the wearer (76% effective as source control). This is a pre-Delta study.Image
Read 9 tweets
Jul 24
Another factor is that children have been turned into let-it-rip vectors of forced mass infection who bring home diseases that debilitate the parents who are out of sick leave while killing the grandparents. sbs.com.au/news/article/a…
And yes, children have been demonstrated to be key vectors of disease.
Note to be forgotten is the adverse effect that infections with SARS-CoV-2 have on fertility. This article reviews the impacts on female reproductive health. frontiersin.org/journals/rehab…
Read 7 tweets

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