#ESMO22 final Presidential Symposium III presentation, #IPSOS, evaluating atezolizumab vs single-agent chemotherapy in pts with advanced NSCLC unsuitable for 1L standard platinum-based chemotherapy, N=453, primary EP: OS ImageImage
#ESMO22 #IPSOS with a median f/u of 41 mo, atezolizumab monotherapy resulted in significantly improved OS (mOS: 10.3 vs 9.3 mo; HR-0.78; P=.028). The improved was seen across subgroups and independent of PD-L1 expression ImageImage
#ESMO22 #IPSOS ORR (16.9% vs 7.9%) and DOR (14.0 vs 7.8 mo) were better with atezo, but no significant difference in PFS was found ImageImage
#ESMO22 #IPSOS median treatment duration was longer with atezo and there were fewer grade 3/4 AE on the atezo arm. 13% of pts on both arms discontinued treatment due to AE. There were no new safety signals; QOL maintained ImageImageImageImage
#ESMO22 #IPSOS overall for patients ineligible for 1L platinum doublet CT (the majority of pts/under-represented in clinical trials), atezolizumab monotherapy prolonged OS over single agent 3rd gen chemo ImageImage

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More from @FrontRowCME

Sep 13
#ESMO22 Presidential Symposium III continued with the eagerly awaited #CodeBreak200 evaluating sotorasib vs docetaxel in pts w/ locally advanced or metastatic KRAS G12C-mutated NSCLC (N=345) presented by @MLJohnsonMD2 from @SarahCannonDocs Image
#ESMO22 #CodeBreak200 met it's primary EP of improved PFS by BICR with a median f/u of 17.7 mo. Median PFS: 5.6 vs 4.5 mo, HR=0.66, P=.002 ImageImage
#ESMO22 #CodeBreak200 ORR was higher in pts treated with sotorasib (28.1 vs 13.2%) and mDOR was longer with sotorasib (8.6 vs 6.8 mo). There was no difference in OS ImageImageImage
Read 7 tweets
Sep 13
#ESMO22 COSMIC-313 presented by @DrChoueiri Triplet therapy with cabo/nivo/ipi vs cabo/nivo for patients with advanced TN advanced intermediate or poor-risk #RCC. Primary EP: PFS; N=855 Image
#ESMO22 #COSMIC313: Longer PFS with triplet vs doublet. mPFS NR vs 11.3 mo with benefit seen in most predefined subgroups #RCC ImageImageImage
#ESMO22 #COSMIC313 ORR 43% vs 36% with 3% CR in both arms; mDOR not reached in either arm #RCC ImageImage
Read 6 tweets
Sep 10
#ESMO22 Presidential Symposium 1 LBA3 TIL vs ipilimumab for advanced melanoma, phase 3 study @HaanenJohn @OncoAlert @myESMO
Unresectable stage IIC-IV melanoma progression with a max of 1 line of prior systemic treatment (not ipi), N = 168, randomized 1:1 TIL vs ipilimumab. Primary EP = PFS; Most pts had prior anti PD-1 treatment ImageImageImage
PFS significantly improved with TIL vs ipi (Median PFS: 7.2 vs 3.1 mo). HR = 0.50, P < .001. The majority of predefined subgroups benefited from TIL ImageImage
Read 8 tweets

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