Thread by @Joni_Coleman

I'm running between eating disorders and bipolar this afternoon. Starting in eating disorders, where Nadia Micali is introducing the phenotypes. Eating disorders are very underfunded given how frequent and deadly they are #WCPG2022

Today's focus is anorexia nervosa, binge eating disorder, avoidant restrictive food intake disorder. #WCPG2022

AN is characterised by food restriction, low body weight [although see atypical AN] and fear of weight gain / weight loss behaviours #WCPG2022

Binge eating is eating a large amount of food with loss of control. In the disorder version, there are no compensatory behaviours (compare bulimia nervosa) #WCPG2022

ARFID is a restricted intake disorder, resulting in persistent failure to meet energy or nutritional needs but without weight concerns (and across BMI distribution). New disorder on the block, research including genetics, building up #WCPG2022

First talk is from Jet Termorshuizen who will discuss the latest @PGCgenetics GWAS of anorexia nervosa #WCPG2022

Last GWAS found 8 loci, SNP h2 11-17% depending on prevalence. Positive RG with psych and physical activity, negative RG with metabolic and anthoprometric. AN is a psychometabolic disorder #WCPG2022

New GWAS - additional data. Imputed to TopMED where possible. MLMs where possible. QC and meta-analysis via the Ricopili pipeline. #WCPG2022

AN 24K cases, 1M controls. PRELIMINARY results show 7 GWS hits and h2 of 8%. Mix of new (2) and replicated (5) loci #WCPG2022

AN-R - no robust GWS hit (one locus, doesn't have LD friends). SNP based h2 of 11%. AN-BP - 1 GWS locus near EPC gene, h2 is 19% #WCPG2022

Genetic correlations - see the same patterns as in last freeze for AN. Some differences between AN-R and AN-BP - AN-R seems to have stronger negative RG for anthropometric traits - need to check further for significance. #WCPG2022

To do - revisit QC etc, understand within sample heterogeneity, sex differences. Sample predominantly of EUR ancestry, efforts to expand to EAS, LAT underway. #WCPG2022