Daniel Goodwin Profile picture
Oct 14 17 tweets 6 min read
It's been another fascinating ~week in twitter biotech. Going back through some highlights...
1/ Of decades of listening to Tom Morello, and years of watching Bertozzi's lectures, I never would have guessed they were college shredmates. Clearly it was an amicable band breakup :) and a wonderful story of Creatives.
2/ Crazy indeed. The amount of work and courage to accomplish something with such an unknown endpoint is really inspiring to me
3/ Besides being a fascinating topic, I LOVE this TRiP system of showing the partner journal (@eLife ) public reviews in the arxiv: I'm interested in computational tools for discovering biotransformation, the reviews contextualize the work
4/ docks docks, docks docks docks docks, docks docks docks docks! Tons of works now becoming public in this area all at once. I'm personally motivated of how we deploy these tools outside of drug discovery
5/ Gnarly story of a new PI. Status quo academia needs a massive overhaul, one of my theses is we just need more competing models universities have to improve their function.
6/ New tool for non-canonical amino acid incorporation, which can further take us into the realm of proteins as programmable nanomachines
9/ Jake's a great guy with tons of knowledge+perspective that he shares openly. This really inspires me to write+share more
10/ Hey protein nanowires are cool let's try to get it working in an industrial workhorse chassis that could eat CO2
11/ When we were working on Expansion Sequencing, I dreamed if we could use light to make NGS identifiers but couldn't figure how to start. Years later, out comes this monster of a paper and was like OK yeah that's a big hard challenge. Amazing work :)
12/ Hey lets grow human brain organoids, graft them into rat cortices and see what happens.
(bc tone is lost online, I mean this respectfully: this does touch on important frontiers but you do have to allow the WUH factor at first)
13/ beautiful work showing that we're stepping towards being able to generate arbitrary geometries of either synthetic (drugs) or organic (protein) parts
14/ Studying genetic toolkits of an organism evolved for hyperaggression. I am curious to read interpretations of the increase in detoxification proteins
15/ Wow, I love this story of studying carbon fixation from a historical perspective. "Resurrecting ancient enzymes" is just a great science pitch, and in a high impact area (Rubisco engineering) that has struggled to make deployable progress
16/OK, that's enough for this week. You can catch me in the front row of this keynote

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More from @D_R_Goodwin

Sep 29
Wow yesterday was a big day on bioscience twitter. Sharing some favorites:
Virtual screening 75M compounds to find a drug that hits the same receptor as LSD et al, but with no reported hallucinogenic effects.
Spatially resolved mass spec workflow at 1um resolution in intact tissue biorxiv.org/content/10.110… Image
Read 5 tweets

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