It's been another fascinating ~week in twitter biotech. Going back through some highlights...
1/ Of decades of listening to Tom Morello, and years of watching Bertozzi's lectures, I never would have guessed they were college shredmates. Clearly it was an amicable band breakup :) and a wonderful story of Creatives.
3/ Besides being a fascinating topic, I LOVE this TRiP system of showing the partner journal (@eLife ) public reviews in the arxiv: I'm interested in computational tools for discovering biotransformation, the reviews contextualize the work
4/ docks docks, docks docks docks docks, docks docks docks docks! Tons of works now becoming public in this area all at once. I'm personally motivated of how we deploy these tools outside of drug discovery
5/ Gnarly story of a new PI. Status quo academia needs a massive overhaul, one of my theses is we just need more competing models universities have to improve their function.
11/ When we were working on Expansion Sequencing, I dreamed if we could use light to make NGS identifiers but couldn't figure how to start. Years later, out comes this monster of a paper and was like OK yeah that's a big hard challenge. Amazing work :)
12/ Hey lets grow human brain organoids, graft them into rat cortices and see what happens.
(bc tone is lost online, I mean this respectfully: this does touch on important frontiers but you do have to allow the WUH factor at first)
13/ beautiful work showing that we're stepping towards being able to generate arbitrary geometries of either synthetic (drugs) or organic (protein) parts
14/ Studying genetic toolkits of an organism evolved for hyperaggression. I am curious to read interpretations of the increase in detoxification proteins
15/ Wow, I love this story of studying carbon fixation from a historical perspective. "Resurrecting ancient enzymes" is just a great science pitch, and in a high impact area (Rubisco engineering) that has struggled to make deployable progress