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Alexandros Marinos 🏴‍☠️ Profile picture
@alexandrosM
Oct 18, 2022 • 25 tweets • 9 min read • Read on X
Deconstructing Evidence-Based Medicine... from the inside out. 🧵

At first, I was shocked with what I was finding. How could anyone not have seen this?

Well, I was wrong. People have DEFINITELY seen it. And have spoken out. In peer-reviewed journals.

Nobody (in power) cares.
Let's start with this excellent paper by Leonid Hanin:
bmcmedresmethodol.biomedcentral.com/articles/10.11… Image
An incredible piece that is extremely readable, and uncovers the whole mess. Image
"Oh come on, Alex, this is some prof from Idaho with a 23 h-index. Is this your refutation?"

I've not even gotten started yet. Image
How about Dr Peter Gøtzsche, over 180 THOUSAND citations, h-index 103 (this means over 100 papers with over 100 citations EACH). Is he credentialed enough?

Oh, yeah, he was also a founder and board member of the Cochrane Collaboration. Image
Here he is explaining why large pharmaceutical companies meet the definition of organized crime:
Here he is explaining how prescription drugs are the third leading cause of death:
Naturally, he was kicked out of Cochrane when he started speaking out: undark.org/2019/12/30/pet…
"Ok fine. You found the village idiot. We keep him around because he has a funny accent".

Funny you should say that, because I have another dude with a funny accent for you:

456 THOUSAND citations, by some accounts, the most cited living scientist. Image
"Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias." journals.plos.org/plosmedicine/a…
Now, keep in mind, Ioannidis and Gøtzsche are two of the authors of the PRISMA statement, which is the consensus standard for how meta-analyses and systematic reviews should be done.

They are EBM royalty. sciencedirect.com/science/articl…
Naturally, all this had been foretold. All the way back in 1998, Charlton and Miles had laid it all out for us. A "science" that is named after the lie that all prior medicine was "not-evidence-based" is a discipline that lives by lies. researchgate.net/profile/Andrew… Image
The author wrote a retrospective 11 years later (13 years ago), basically explaining to us what would happen during the pandemic, when even the basic guardrails were thrown out because "EMERGENCY!!!"

The paper is unpaywalled on his blog:
charltonteaching.blogspot.com/2009/08/zombie… Image
In fact, this is not a medical, or for that matter, scientific problem at all. Deming had explained the problem of metrics-driven managerial top-down authoritarianism years ago.

PLEASE watch this video to the end. Don't let his deadpan humor fool you:
Much more material can be found in this book that I will never stop recommending:
press.princeton.edu/books/hardcove…
And that's how we got here.
It's not about the evidence. It never has been.

Incentives rule everything around me.
Image
I hope this thread can serve as a reading list of material for people who have run into the same mess I did a year and a half ago, so they don't have to spend 18 months reconstructing it.

The evidence against evidence-based medicine is as conclusive as it is damning.
Brought to you by... SCIENCE! ImageImage
ps. how did I forget this? bmj.com/content/376/bm…
ps2. this thread is dedicated to John Lykoudis - a name everyone should know.
ps3. Another epic piece, this time on nutrition "science".
I actually consider this an optimistic thread. Whenever I've seen evidence of rot that is *this* clear, this public, the narrative eventually shifts. Maybe it will take a decade. Or maybe it will take longer. But it will shift. The question is "to what?"
Turned this to a substack article, for those who prefer their twitter threads all in one place: doyourownresearch.substack.com/p/deconstructi…
The biggest reason I make these threads, and why I post them on Twitter, is all the additional material that comes up in the responses. In particular this video by @p_parry1 is an excellent complement to this thread. ImageImageImageImage

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More from @alexandrosM

Alexandros Marinos 🏴‍☠️ Profile picture
Dec 3
Did you now that the PRINCIPLE trial out of the UK found that IVM was superior to the usual care in practically every subgroup it tested, but it sat on the results for ~600 days? When it finally published, it buried these results in page 346 of the appendix. Image
The main body of the paper they published is even more bizarre --

1. They claim that "clinically meaningful" meant 1.5 days improvement in median time to recovery.
2. They admit that ivermectin showed >2 days to recovery.
3. Their main conclusion is that ivermectin is unlikely to provide clinically meaningful improvement in recovery.

sciencedirect.com/science/articl…Image
Image
Image
The secret sauce in their conclusion is that their target metric of HR 1.2 is based on 9 days of recovery needed (after randomization). Even though they had ran many hundreds of patients by the time they started the ivm arm they knew the days needed for recovery were >14.
Read 21 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Apr 19
Let's do a thread doing a close reading of Douglas Murray's article in the NY Post, in which he writes about his encounter with Dave Smith on Joe Rogan's podcast.

If you care about facts and truth and stuff, I promise this will be highly illuminating. 🧵 Image
Early in the article he writes this:

"Having not spoken to Joe since the wars in Ukraine and Israel started, I had become increasingly irked that the guests he has had on have been almost entirely anti-Ukraine and anti-Israel."

As many have demonstrated, this is false.
Since late 2023, at the very least these guests with strong pro-israel views have appeared at least once on the podcast.

Gad Saad
Mike Baker
Peter Zeihan
Douglas Murray
Coleman Hughes
Konstantin Kisin (3 times)
Read 45 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Mar 26
A thread where I post a bunch of receipts of interesting information on the Jefferey Goldberg Signal leak of Yemen war plans.

1. It appears Signal was not only allowed but recommended for government officials?
2. This might have been the JG that Waltz was trying to add to the groupchat?

3. Tulsi Gabbard (and pretty much everyone else except for Goldberg) claims no classified information was shared in the chat.
Read 17 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Feb 19
Is Zelensky operating with out a mandate?

I dug into the constitution of Ukraine to figure this out for myself.

Article 103, paragraph 5, clearly says that the presidential elections should have been held in 2024.

(thread continues below) Image
Article 83 also says that if the president declares martial law, then the **parliamentary** elections can be delayed until martial law is lifted.

Notice that it doesn't say that the presidential elections can be postponed.

English translation here: natlex.ilo.org/dyn/natlex2/na…Image
So, the Ukranian constitution gives the president the power to declare martial law, and explicitly says that parliamentary elections can be delayed until after martial law is lifted. For presidential elections it says they must happen every 5 years with no martial law exception.
Read 8 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Jan 26
Whitney Webb's failure to admit error, (and how to survive the 2025+ infowars without getting blackpilled)

I had a run-in with Whitney Webb this week. This THREAD will try to walk you through the story in excruciating detail.

This will take a while, but I think it's worth it.
It all started when @BretWeinstein thanked @POTUS for withdrawing from the WHO. Bret had fought long and hard against the WHO pandemic treaty that was being pushed, so whoever had followed him knows how important this is.
@BretWeinstein @POTUS Whitney Webb felt the need to point out that "Trump also left the WHO in mid-2020 and then just redirected what was once WHO funding to the Gates-funded GAVI vaccine alliance."

Read 44 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Jan 21
Your favorite blackpill dealer, Whitney Webb, here with more trash data and vague insinuations.

In this episode, she claims Trump "redirected" WHO funding to GAVI. In reality, she is asserting that unrelated funding from USAID to GAVI was made because of the withdrawal from WHO in 2020.

The USAID funding to GAVI was part of a long-term funding stream that USAID had been providing to GAVI since 2001.

more details here:
usaid.gov/sites/default/…Image
Some people are saying that maybe the 1.4B in 2016-2020 was concentrated in 2020. Not true. A billion was pledged for the period of 2015-2018. Then 1.16 billion was pledged for the period between 2020-2023. Taking inflation into account, that is effectively the same amount, for the same duration of time.

gavi.org/investing-gavi…Image


And more receipts for the years 2018 and 2019 csis.org/analysis/susta…Image
Read 6 tweets

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