Vinay Prasad MD MPH Profile picture
Oct 20, 2022 6 tweets 3 min read Read on X
ACIP slides: it is a BAD decision to add this to the SCHEDULE 👇

This vaccine has (a) no convincing evidence it helps the 86% of kids who already had covid & (b) no evidence it will help kids in 2027 against whatever new strain comes

CDC data shows parents don't want it🧵
93.1% of parents don't want to vaccinate their young kids

That is for good reason; there is no RCT data this vaccine lowers severe disease in this age group, and even the observational studies I am aware of (flawed) look at 5-11

No study pertains to kids where 86% had covid
CDC slides also full of errors and bad decisions

They are stacking 2 booster doses in adolescents-- this should raise concern of unnecessary myocarditis that might be averted with omission or spacing the last dose
They assert this as fact, but surely at some point the calculus tips

a 20 year old man who got 3 doses and just had OMICRON- benefits from a bivalent booster targetting an earlier strain?

No evidence supports this, and it is nonsensical

What about dose #20?
This slide does not account for changing facts on the ground. Omicron and prior immunity have drastically changed these numbers

PS these numbers we also wrong when they first put them forth, as we explained

medpagetoday.com/opinion/second…
Denmark is limiting vaccination to kids and young people.

US CDC has lost perspective, they are out of touch with data, the American people, and common sense

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More from @VPrasadMDMPH

Nov 29
Here's what they are not saying
Vaccine hesitancy has been rising for some time. This includes preventable illnesses like measles. There will be measles outbreaks in the future! Covid policy accelerated hesitancy. The question is: how many extra outbreaks will occur bc of RFK...
... If RFK is HHS secretary, versus if RFK is not HHS secretary. That's the question.

Even though he has tremendous administrative authority, he has already stated he's not going to withdraw these vaccines. I also suspect it's not going to be the first topic he touches...
Moreover, I and others have repeatedly provided compromised positions where we can improve safety detection of current vaccines. The current system can be honest and admit that our vaccine surveillance is abysmal. Companies don't want safety discovered.
Read 9 tweets
Nov 22
Every single one of these garbage papers use the denominator of PCR+ covid infections, and not the actual denominator of people who had covid-- many do not present to the doc. Every single one of these papers is shit. I would be embarrassed to be an author. Incompetent work. Image
People with covid who are so sick they have to go to the doctor have poorer health than people who don't. That should be in the journal of obvious things. All of these authors are extrapolating beyond the evidence. They're creating a body of trash calling itself science
Is there a single paper that uses a sero prevalence denominator? Is there a single researcher in this field whose brain is working? Just one. That's all I ask for.
Read 7 tweets
Oct 3
Totally wrong. Because Vincent is not thinking about the counterfactual correctly.
*Teachable moment*

1 These drugs were approved by accelerated approval in the LAST line. Some later improved survival & others didn't in an EARLIER line.

2 The counterfactual to AA... 🧵
is demanding RCTs powered for say, OS (survival). If a company couldn't use RR to get AA, they wouldn't run a trial in the 2nd line or 3rd line setting powered for OS, they would run it in the 7th or 8th line

Why? more dire = faster result
3. We have proven that in these v late lines RR and median DOR (the current AA criteria) result just as fast as OS
pubmed.ncbi.nlm.nih.gov/30933235/
Read 10 tweets
Sep 29
Many people want covid to be worse than it is. They imagine it has long-term consequences that are worse than other respiratory viruses. Adjusting for severity of illness, it doesn't. Only anosmia is unusual. Why do they want it to be worse than it is? 🧵
For some reason, some people want to live with perennial precautions. They don't want to take off the mask, they want their children to mask, they want to keep getting booster after booster. I don't know why but they want to live in fear.
They have...
A mountain of retrospective observational data that they think supports their claim that covid has long-term disability. That it's a vascular disease. And all sorts of other claims. Nearly all these studies are flawed. They don't have good controls.
Read 15 tweets
Sep 25
I spent a lot of time today reading this paper, the criticism, the rebuttal, the retraction notice. OMG! My head hurts.

But... An important point no one has said is that the entire premise of the study & criticism is flawed. 🧵 Here is a short summary
Lots of prior studies show many psychological findings don't reproduce. Obviously that's because so much of this science is bullshit. Small sample size, weak methods. Entire fields struggling to justify their existence & people p hacking and exaggerating to be on @HiddenBrain
How do you fix this problem? No one really knows. All of academia is incentivized for hype and discovery, actually being a thoughtful student, criticizing things, pushing for better methods that's unpopular.
Read 17 tweets
Sep 14
Thank you @Erman_Akkus for ur reply it is a good learning opportunity for #ESMO24

In 15 tweets, I will summarize the trial, my criticism, and why this reply contains 3 common errors that oncologists make because our training doesn't teach these ideas.

First, the trial... Image
The trial is #LEEP-012 and randomizes pts with INCURABLE (see pic) liver cancer to TACE (embolization) plus costly drugs or embolization alone.

These 2 drugs are TOXIC (lenva is horrible) and cost a FORTUNE 200-300k per annum per person
#ESMO24 Image
Every single person has the cancer return. It is non-metastatic, as @Erman_Akkus says, but it is not curable.

Here is the time until measured lesions grow 20% or new lesions present or the patient dies

That's what he and others are excited by #ESMO24
a 4 months PFS Image
Read 16 tweets

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