New publication alert! Check out our theory piece at @BiologicalPsyc1 where @xiaosigu and @isssaez discuss the potential benefits of combining two disciplines: invasive intracranial intervention in humans and computational psychiatry. 🧵1/7
doi.org/10.1016/j.biop…
doi.org/10.1016/j.biop…
How can we translate computational psychiatry approaches into effective treatments? How can we leverage invasive interventions in humans for psychiatry applications? We believe these answers require collaboration between our disciplines. 🧵2/7
First, invasive approaches (such as sEEG in epilepsy patients) provide a spatiotemporally precise depiction of neural activity that is normally not available in human studies. 🧵3/7
Second, they allow precise stimulation of individual brain regions and circuits, which can provide causal insights and open up novel therapeutic possibilities. 🧵4/7
Third, by using computational psychiatry approaches, we can identify brain areas with aberrant computations that can serve as the basis for novel invasive stimulation techniques in the context of damaged behavior – we call this algorithmic targeting. 🧵5/7
Of course, invasive interventions are done in a very specific clinical context and require patient involvement, so we also discuss the ethical and practical framework for these new approaches. The wellbeing of our patients always comes first. 🧵6/7
In summary we hope that this methodological combination will prove a fruitful avenue that can provide new mechanistic insights into human thoughts and actions and provide important therapeutical clues for developing new treatments for devastating psychiatric conditions 🧵7/7
Look out for invasive computational psychiatry collaborations from Mount Sinai @sinaiCCP @isssaez @xiaosigu @angelaradulescu @MountSinaiDBS @SinaiBrain #electrophysiology #computationalpsychiatry #collaborativescience
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