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P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
@Mangan150
Oct 28, 2022 • 7 tweets • 3 min read • Read on X
Exercise kills cancer.

When serum from men who performed a bout of high-intensity exercise was added to cancer cell culture, the cells died. No effect on normal cells.

Every time you exercise with intensity, you're inhibiting cancer. Image
The anti-cancer effect may be due to reduced levels of IGF-1 (insulin-like growth factor) and/or increased levels of IGF-1 binding protein.
ncbi.nlm.nih.gov/pmc/articles/P… Image
High levels of physical activity are associated with reduced rates of many types of cancer.

In some cases as little as half the risk.
pubmed.ncbi.nlm.nih.gov/27183032/
Oxytocin mediates the beneficial effects of exercise training on breast cancer

Exercise robustly increases levels of the hormone oxytocin, which decreases growth of cancer

physoc.onlinelibrary.wiley.com/doi/full/10.11…
Oxytocin promotes rejuvenation and muscle regeneration, and declines with age.

There are ways to raise it

Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age

One of the modulators was oxytocin

ncbi.nlm.nih.gov/pmc/articles/P…
High intensity exercise reduces colon cancer cell growth.

Each bout of intense exercise inhibits cancer.

One more reason to exercise. Image

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More from @Mangan150

P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Dec 10
The 3 practical ways to get healthier:

1. Getting leaner
2. Getting fitter
3. Getting stronger

Here’s what I mean by that:
Getting leaner means losing weight.

But more specifically, it means losing fat while protecting against muscle and bone loss.
Getting fitter means improving exercise capacity.

It’s also referred to as “improving cardio” or increasing endurance.
Read 7 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Nov 5
A short guide for new readers:

The number 1 cause of chronic disease, including heart disease, many cancers, Alzheimer's, dementia gout and (almost) anything you care to name, is poor metabolic health.

Let me explain:
Poor metabolic health is most commonly visible to the naked eye based on 2 factors:

-Excess body fat (being over fat, no matter the BMI)
-Low muscle mass (being under muscled, again, no matter the BMI)
The official term for poor metabolic health is insulin resistance.

My shortcut is this: the opposite of poor metabolic health = being lean and fit.
Read 5 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Sep 26
Top 4 metabolic health and body composition levers, in no particular order:

1. Resistance training
2. Nutrition optimization
3. Cardiovascular training
4. Sedentary-busting physical activity

Here’s why:
Resistance training is by far the most predictable way to:

1) Protect against muscle and bone loss that would otherwise happen as one ages

2) Build new muscle

New other form of training, no sport or physical activity is anywhere near as effective.
By nutrition optimization, I mean being intentional about what, how and when you eat.

I can craft arguments for and against different diets and ways of eating.

The most unambiguous fact is that it’s better and easier to be lean and fit if you mostly eat real whole food.
Read 6 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Sep 19
My top 5 bare minimum health targets:

Ferritin under 100
A1C in normal range
Normal blood pressure
Waist to height ratio under .5
Triglycerides/HDL ratio under 2

Here’s why:
Ferritin under 100:

Optimal ferritin levels for cardiovascular mortality reduction may range from 20 to 100 ng/ml

Ferritin can mainly be lowered through blood donation and therapeutic phlebotomy.
A1C in normal range:

This one is hopefully self-explanatory, since you want to be as far away from diabetes, and don't want to be prediabetic either.
Read 8 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Sep 6
You may have never heard of it, but insulin resistance is the most important concept for those who care about their health.

Let me quickly explain it, in a simplified way:
First: it’s easier to understand insulin resistance as a continuum from excellent to very poor metabolic health.
Someone who is in excellent metabolic health is what’s called “insulin sensitive”

They almost surely have low body fat levels and:

-Low triglycerides
-Normal or higher HDL
-A1C in the normal range
Read 11 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Aug 27
Could we prevent most cancer cases, today, without any new technology?

I think we can.

Here's why: Image
Cancer is rare in young people, but common in older people.

In fact, about 90% of all cancers happen to people over the age of 50.

And 50% of ALL cancers happen with people over 70. Image
So now we must ask:

Why does almost every cancer case happen later in life?

Could it be simply because older people are, on average, in worse metabolic than young people? Image
Read 11 tweets

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