IMS symposium on CVD at midlife.
First speaker Prof Chrisandra Shufelt (USA).
MHT and CVD: looking back before moving forward. Image
KEEPS looked transdermal vs oral estrogen, using annual CIMT. No sigt diff.
#IMS2022 Image
ELITE looked at CIMT in groups <6 or >10 yrs post menopause. Increase in CIMT was lower in the early menopause group but not at a level to affect relative risk for CVD. #IMS2022 Image
Women with POI should receive MHT unless contraindicated. #IMS2022 Image
Next speaker. Prof Lisa Larkin (USA)
Migraine management across the lifespan. Image
CVD and stroke risk inc in patients with migraine with aura. #IMS2022
Early treatment of migraine with triptans increases response and decreases recurrence.

Migraine can worsen at peri menopause and improve after menopause.
Injectable CGRP mAbs are effective.
New agents- oral CGRP ‘gepants’. #IMS2022 Image
Next speaker. Prof Tomi Mikkola (Finland).
History of pre-eclampsia as a CVD risk factor among menopausal women. @IntlMenopause Image
A history of pre-eclampsia predisposes a woman to approx two fold risk of CVD later in life. #IMS2022
Hormone therapy may prevent IHD and stroke in these patients. Image
Just an aside. The best academics say ‘I don’t know’ quite frequently during question time.

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More from @KarenMagraith

Oct 29
Last day of IMS.
Debate: are we over-treating with hormone therapy?
First speaker Prof Martha Hickey (Australia)
For the motion. #IMS2022 Image
Argues that the only primary indication for MHT is VMS (not mood, not sleep and not for primary prevention of disease).
Quotes US preventive task force. Image
Discusses Collaborative group on hormonal factors in breast cancer. (Lancet)
Observational study.
#IMS2022 Image
Read 12 tweets
Oct 28
Final plenary for today.
The microbiome: endocrine nexus in human health.
Prof Jack Gilbert (US). #IMS2022 Image
Our immune system regulates our microbiome.
Can be in a state of homeostasis or dysbiosis.
Dysbiosis can lead to diseases.
During menopause a reduction in microbiome diversity tends to occur.
Can affect hormones and metabolic factors eg lipids, and weight.
May affect brain chemistry and mood too.#IMS2022
Read 4 tweets
Oct 28
IMS Congress day 3.
Starting very early with concurrent presentations from menopause societies.
AMS presentation on Menopause and work.
Chaired by Dr Sylvia Rosevear (Aotearoa/NZ). menopause.org.au
I was the first speaker.
Case studies in menopause at work.
I began by acknowledging that some people who experience menopause don’t identify as women. Gender diverse people can also experience menopause.
#IMS2022
Whether a workplace is menopause supportive or not can make the difference between someone staying in their workplace or leaving.

This in turn can have long term impacts including on life trajectory, and retirement income. #IMS2022 Image
Read 17 tweets
Oct 27
Next session. Hormones.
First speaker Prof Alfred Mueck.
Principles to select estrogens.
Conjugated equine estrogens - contain a lot of substances, in variable amounts.
Suggests we move away from its use. #IMS2022 Image
Estradiol containing COCPs. Took a while to develop because of bleeding issues.
Now we have pills with good cycle control, because of the progestogen. Dienogest or nomegestrol. #IMS2022
Next speaker Prof Nick Panay. (UK)
Optimizing hormone therapy through choice of progestogen/progesterone.
#IMS2022 Image
Read 9 tweets
Oct 27
Next session. Debate. MHT for primary prevention. For: Prof Robert Langer. Begins by revisiting WHI #IMS2022 Image
Describes preventive effects of MHT on CHD and other conditions. Choice of progestogen important. #IMS2022
Against: Prof Mary Ann Lumsden (UK). Image
Read 8 tweets
Oct 26
I’ll be tweeting when I can from the International Menopause Society Congress.
#IMS2022
Starting with the meeting before the meeting.
The Council of Affiliated Menopause Societies.
Societies from around the world connecting and collaborating.
Welcome from IMS President Steven Goldstein.
#IMS2022 Image
New CAMS chair Dr Duru Shah pointing out that the number of women over 60 is expected to double by 2050.
UN priority is to reduce health inequities and ageism and promote healthy aging. Image
Read 16 tweets

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