Thomas Morris Profile picture
Oct 28, 2022 15 tweets 6 min read Read on X
Today is the 150th anniversary of a historic operation performed by this surgeon - George William Callender. Few people know his name now, but Callender was once described as the first person to operate on the human heart.
Callender was born in 1830 in Bristol and won a scholarship to St Bartholomew's Hospital in London. Smart both intellectually and sartorially, he amused the other students by always insisting on changing into evening dress for dinner - even when dining alone.
On October 28 1872, Callender was on duty at @BartsHospital when a 31-year-old man arrived on the ward. He had previously been examined at the hospital and told that nothing was wrong with him - but after nine days of severe pain he decided to return. Which was just as well.
The man had got into a fight in a local pub, felt a sharp pain in his chest and noticed that a long sewing needle he'd been keeping in his breast pocket had disappeared. He assumed it had somehow pierced his chest - but there was no sign of a wound.
Callender and his junior surgeon examined the patient. At first they saw and felt nothing - but eventually they noticed a tiny, tiny bump on the left side of the chest. This not-very-helpful diagram is Callender's attempt to show its location.
So Callender took him to the operating theatre for further investigation. After giving the patient chloroform he made a small incision and dissected away the subcutaneous fat to find... the broken eye of a needle.
The needle moved visibly with the patient's heartbeat. Callender grabbed it with forceps and carefully pulled it out. It was almost two inches long.
From the length of the needle and the degree of oscillation, Callender inferred that it had pierced the heart just above the apex - near the tip of the left ventricle.
The patient made a good recovery and felt no pain. Callender observed that the heart rhythm seemed unaffected by the procedure, although the pulse was elevated the following morning. His colleague Lauder Brunton took this tracing of the patient's radial pulse with a sphygmograph.
The case caused something of a sensation. It was - and still is! - regarded as the first time in history that a patient had survived an operation to remove a foreign body from the heart. For a time it even became known as 'Callender's operation'.
One late nineteenth-century textbook even described this as heart surgery, but that's going too far: Callender didn't even lay eyes on the organ. He did save his patient from a potential cardiac death, however.
Callender went on to become a celebrated anatomist and Fellow of the Royal Society - but he suffered from chronic nephritis (known then as Bright's disease), which killed him at the sadly early age of 49.
Heart surgery as we know it did not get underway until 1896, when Ludwig Rehn became the first to suture the beating human heart - but 150 years ago, George William Callender showed his colleagues a glimpse of the surgical future.
I forgot to add that the needle Callender removed from his patient's heart still survives in the collection of Bart's Pathology Museum @BHAandM - I've seen it myself.
The inscription, written shortly after the operation in October 1872, reads: "Needle removed from heart nine days after its insertion. Length 1.9 inches. The patient recovered."

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More from @thomasngmorris

Dec 31, 2021
There's a lot of stuff on Twitter at the moment about Covid-related science communication, good and bad.

So this seems a good time to share a interesting example of a scientific urban myth that I've just come across. Here's a short THREAD.
On my morning walk I was listening to a 2013 edition of @BBCRadio4's reliably funny panel show The Unbelievable Truth. At one point in this programme, the presenter @RealDMitchell's script asserts that: Image
"In 2005, scientists at the University of Groningen revealed that men and women find it easier to achieve orgasm whilst wearing socks. The scientists believe this is because the couples were more comfortable and therefore more relaxed when they didn’t have cold feet." Image
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Sep 9, 2021
Cardiac surgery is 125 years old today! On September 9 1896, the German surgeon Ludwig Rehn performed the first successful operation on the human heart.
Born in Allendorf, Germany, in 1849, Rehn had an unusually varied career. While working as a GP near Frankfurt he noticed that workers at a local chemical works were prone to bladder cancer - deducing that the cause was a chemical they worked with, aniline.
But he's better known for this famous paper, published in 1897. It begins: "In a desperate case of a stab wound of the right ventricle, I was forced to operate because of persistent bleeding." A sentence that heralded the era of cardiac surgery.
Read 13 tweets
Sep 2, 2021
How did Alexander Graham Bell and Wilhelm Roentgen contribute to a historic surgical operation that took place 125 years ago next month? Here's a THREAD about a presidential assassination, the inventor of the telephone, and the evolution of medical imaging.
The story begins on July 2 1881, when President James Garfield was shot at point-blank range while waiting for a train in Washington D.C. His attacker was immediately arrested, but the President was gravely wounded.
Over the next few weeks, President Garfield's life hung in the balance. His doctors wanted desperately to remove the assassin's bullet, but had no idea where it had ended up, and no means of finding out.
Read 25 tweets
Jul 2, 2021
Just stumbled across some fantastic photos of the RAF Symphony Orchestra's 1944-5 tour of the USA. Including my dad, aged 24, who played the flute in the orchestra and the RAF Central Band throughout the war. @RAFMusic Image
Standing to the left of my dad is, I think, the celebrated horn player Dennis Brain, taking a photo of his own. Image
Aficionados of 20th-century British music may notice other great names here including the conductor Norman del Mar, bassoonist Cecil James, and violinists Sidney Griller and Frederick Grinke. Image
Read 4 tweets
Jan 23, 2021
This historic document is the first electrocardiogram (ECG), recorded in 1887 by the British physiologist Augustus Desiré Waller. Image
By the 1880s, experiments had already shown that electrical activity played an important role in cardiac function. In 1878 John Burdon-Sanderson demonstrated the sequence of tissue depolarization and repolarization that accompanied the beating of a frog's heart. Image
In 1885, Waller (r) started to investigate electrical activity in animal hearts using a Lippmann capillary electrometer, an instrument which employed a column of mercury to detect electrical current. Tiny deflections in the height of the column were observed through a microscope. ImageImage
Read 12 tweets
Jan 5, 2021
A few years ago a 59-year-old man walked into a hospital in eastern France and asked to see a doctor. He had no symptoms, but said he had been advised to get an X-ray. This is it: Image
A lateral view gives a slightly clearer view of a foreign body in the lower lobe of the left lung. What could it be? Image
A dental drill bit! The patient explained that a little earlier his dentist had accidentally dropped it in his mouth and he had inhaled it. It had caused no immediate trouble but the dentist, aghast, told him he needed to get it extracted ASAP. 😱 Image
Read 6 tweets

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