Thread by @AllisonHamilos

As promised at today's #SfN2022 Neurobiological Basis of Timing NanoSymposium, I'm posting some answers to questions about my talk that we didn't have time for! Here's question #1...(a thread!) @TimingForum @aysha_motala @MartinMwiener #SfN22 (1/12)

Here's what's been seen before in mice making self-initiated licks! pubmed.ncbi.nlm.nih.gov/30323275/ (2/12)

The signals we see in self-timed licking are similar, but with some differences! But maybe we'd see similar things in self-initiated licking if we knew what to align signals to. (3/12)

Here's how we looked at self-initiated licks in our animals. Note that we can't rule out if they're self-timed...these are animals trained to do a timing task after all. (4/12)

Here's how we looked at the self-initiated licks in the ITI... (5/12)

We see some similarities! (6/12)

Also, check out these dips in dopaminergic signals after the lick initiates...Joey Floeder who presented before my talk also showed these in his dataset! (7/12)

Others have seen these dips, too... (8/12)

(9/12) abstractsonline.com/pp8/#!/10619/p………
@neurojaym

Pure speculation...but intriguing! (10/12)

These figures are from our GLM encoding models...but the raw data shows the same patterns...just convenient to pull these figs from our paper to show here. (11/12)