The Covid situation in China is not looking good right now. The authorities have trapped themselves into a situation from which there's no obvious escape strategy. Whatever they choose - or will be forced - to do next will be very costly.
1/
China has managed to suppress SARS-CoV-2 with brutal restrictions. Those are becoming increasingly untenable as the population is suffering. A major surge seems largely inevitable in the short term unless the authorities chose to enforce even more ruthless measures.
2/
A major Covid-19 surge in China would lead to a dramatic death toll. Current SARS-CoV-2 Omicron lineages in circulation are 'milder' than Alpha or Delta, but the associated morbidity / mortality is in line with early pandemic SARS-CoV-2 lineages for those with no immunisation.
3/
China is extremely poorly prepared for a major Covid surge. Very few people have acquired immunity to the virus through prior exposure and vaccination rates in the elderly are dismally low.
4/
asia.nikkei.com/Spotlight/The-…
China's population is not particularly young nor healthy and its healthcare system is fragile, in particular outside major cities. It would be easily overwhelmed by any significant surge in Covid-19 cases.
5/
researchgate.net/publication/33…
Hong-Kong faced a similar set of challenges in early 2022, and despite far better fundamentals, it fared poorly when Omicron spread.
6/
ft.com/content/6e610c…
The most plausible scenario to me is that China will experience a major Covid surge in the near future leading to massive morbidity and mortality, which could be amplified by a collapse of the entire healthcare system.
7/
Beyond the immediate death toll, the failure of a zerocovid strategy would be difficult to handle by Chinese authorities, given the immense political capital they invested into it since early 2020.
8/

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More from @BallouxFrancois

Nov 29
A widespread concern about the likely incoming surges of Covid cases is that they may lead to the emergence of new SARS-CoV-2 variants. I'm personally not convinced this is what we should be obsessing over in the face of a looming humanitarian disaster
1/
The three main Variants of Concern (VoC: Alpha, Delta and Omicron) likely emerged during long-term infections in immunocompromised hosts (the evidence is less clear for Delta).
2/
A large number of additional cases in China would only marginally increase the risk of emergence of a VoC in an immunocompromised person, but the slight additional risk would be down the line in 6-12 months.
3/
Read 6 tweets
Nov 26
New paper on non-lethal sampling of Ranavirus in amphibians.
Ranaviruses are DNA viruses with an exceptionally broad host range among cold-blooded vertebrates (amphibians, reptile and fish).
1/
mdpi.com/1999-4915/14/1…
Ranavirus are a major threat for several species of amphibians. They reduce the viability of infected amphibian populations, which often already struggle with pollution and habitat loss, but can also cause devastating outbreaks in pristine habitat.
2/
sciencedirect.com/science/articl…
Current standard practice is to kill the animals when testing for subclinical infection. This is particularly problematic for threatened / vulnerable populations / species. This work evaluates the relative performance of various lethal vs. non-lethal sampling procedures.
3/
Read 6 tweets
Nov 18
I find the fall from grace of Professor Didier Raoult fascinating to watch. Though, what few seem to fully appreciate is that he's merely a symptom of many things that are deeply dysfunctional in academia, rather than a cause, or even an outlier.
1/
He represents the epitome of absolute power in academia, putting his name on endless papers he may not even have read, with many of those being completely irrelevant, and using his huge power to heap abuse on anyone who dares to challenge him.
2/
Raoult will be gone soon, but the system that allowed him to rise to the top largely remains in place. Highly hierarchical academic environments, such as those found in several countries in Asia and continental Europe are particularly vulnerable to this type of power abuse.
3/
Read 4 tweets
Nov 14
I generally try to avoid 'Tik-Tok takes' on Covid, because I appreciate things are complicated, and there are alway exceptions to any pattern. That said, for the sake of everyone's sanity, let me be clear.
1/
There is no evidence at all that mild Covid does 'destroy immunity' and make people more susceptible to other infectious diseases. The naive T-cell depletion, super-antigen trope or whatnot doomsday immunity hypotheses are nonsense supported by no robust scientific evidence.
2/
'Immunity debt' might well be a divisive term, but what it captures is something trivial and genuine. We all get exposed on a regular basis to myriad respiratory diseases. This is not necessarily great but it allows us building up immunity to those viruses and close relatives.
3/
Read 5 tweets
Nov 9
New preprint suggesting that rapid expansion of naive T cells can provide a fast and effective immune response to SARS-CoV-2, and likely other viral infections.
1/
biorxiv.org/content/10.110…
We all have a large repertoire of naive T-cell precursor clones that recognise different bits of pathogens (epitopes). The relative frequency of those populations of clones is highly variable, with some being far more common than others.
2/
If some of the abundant naive T-cell clones happen by chance to recognise epitopes of an invading virus, they can expand fast enough to control and abort the infection, sometimes possibly even before seroconversion (ie. antibodies kicking in).
3/
Read 5 tweets
Nov 6
As all the cool kids are migrating to Mastodon, I've also set up an account there. The way things are going, I may well relocate all my social media activity to Mastodon. If so, I hope to meet many of you there in the future.
@FBalloux@genomic.social
1/ Image
Twitter's ability to deliver information in real time is amazing. I also value the opportunity to debate with people from all ways of life. Conversely, Twitter's noxious. I anticipate quality content to go down and abuse to go up under its new unsustainable business model.
2/
I wouldn't expect to reproduce my Twitter experience on Mastodon. I actually don't want a Twitter ersatz. If I jumped social media platform I'd hope to learn things and engage in interesting discussions, without the toxicity and abuse that comes with a big account on Twitter.
3/
Read 12 tweets

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