[1/3] A 2015 study (1) on adults intranasally receiving FluMist live attenuated vaccine found "significant changes in microbial community structure, diversity, and core taxonomic membership as well as increases in the relative abundances of Staphylococcus and Bacteroides genera". 
[2/3] It suggested "activation of a type I interferon (IFN)-mediated antiviral response may foster the disproportionate emergence of potentially pathogenic species such as S. aureus." Prior murine studies (2, 3) found colonization by such bacteria enhanced by type I IFN.
[3/3] Do you know #AllTheRisks of FluMist impacting bacterial composition in the nasal microbiota, as evidenced by isolation of bacterial genomic DNA and subsequent 16S rRNA gene amplification?
(1) ncbi.nlm.nih.gov/pmc/articles/P…
(2) journals.asm.org/doi/pdf/10.112…
(3) ncbi.nlm.nih.gov/pmc/articles/P…
(1) ncbi.nlm.nih.gov/pmc/articles/P…
(2) journals.asm.org/doi/pdf/10.112…
(3) ncbi.nlm.nih.gov/pmc/articles/P…
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