At @OpenAI, we believe that AI can accelerate science and drug discovery. An exciting example is our work with @RetroBiosciences, where a custom model designed improved variants of the Nobel-prize winning Yamanaka proteins. Today we published a closer look at the breakthrough. ⬇️
The Yamanaka factors (OSKM) are four proteins that have revolutionized biology due to their ability to generate induced pluripotent stem cells (iPSCs) and rejuvenate cells. Unfortunately, they suffer from extremely low levels of reprogramming efficiency.
Together with the team at @RetroBiosciences, we’ve designed novel variants of the Yamanaka factors that achieve a 50x increase in reprogramming efficiency in vitro compared to standard OSKM proteins – a groundbreaking improvement.