Thread by @TactNowInfo

"Immune cell dysregulation is a driver of COVID severity" (peer-reviewed)

"decreased total conventional DC (cDC), conventional type 2 DC (DC2), and plasmacytoid DC (pDC) (Fig. 2, C and D). CyTOF also showed lymphopenia of CD4 and CD8 T cell populations"

eurekalert.org/news-releases/…

An immunologist writing a peer-reviewed paper on immune dysfunction & lymphopenia.

Wish it weren't true but the good news is mild cases recover. The problem is how fast reinfections often occur.

Dr. Sacha Gnjatic received his PhD in Immunology from the University of Paris VII.

Paper on persistent infection in asymptomatic children's tonsils that may contribute to transmission,showed similar results.

Fig. 2 "Proteomic characterization of COVID serum reveals distinct immune patterns associated w/disease severity & clinical outcome."

#Immunedysfunction

ACE2-independent infection of T lymphocytes by SARS-CoV-2"

"This work confirmed a SARS-CoV-2 infection of T cells, in a spike-ACE2-independent manner, which shed novel insights into the underlying mechanisms of SARS-CoV-2-induced lymphopenia in COVID."

nature.com/articles/s4139…

We know COVID infects immune cells. We know immune cells are depleted.

"COVID assembles viral factories, impairs cell function and may cause cell death. COVID infected T helper cells express higher amounts of IL-10, which is associated with viral persistence & disease severity."

"CD4-mediated SARS-CoV-2 infection of T helper cells may explain the poor adaptive immune response of many COVID-19 patients." ⬅️

medrxiv.org/content/10.110…

"Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) outcomes due to immunosenescence and certain age-dependent medical conditions." ⬅️ Wait a minute.. COVID causes immunosenecsence.🥴
medrxiv.org/content/10.110…

Reinfections bypassing antibodies, infecting T-cells, dendric cells, & neutrophils leads to senescence.
We are aging our immune system years per infection which is shortening lifespans a decade w/reinfections. Protect yourself and our children's future.

https://twitter.com/TactNowInfo/status/1592508742184366080?t=CzCjtVJDcS0_ZhvmvlrTpw&s=19

Recap:
1. Infections cause temporary lymphocytopenia in many mild cases. It can take months to recover. That opens up the possibility of other infections.

2. Reinfections occur 1 - 2 x a year if taking care to mitigate and still active. Every few months or weeks is possible.

3. Immunosenescence causes more severe COVID.

COVID leads to rapid Immunosenescence costing our cells years of life.

Therefore each reinfection will increase risks even if that person has a fully recovered immune response after prior infection.

4. If reinfected prior to immune system recovery then the increased risk would be combined with the already increased risk from the aging of our immune system cells.

Reinfections are then creating a downward spiral in health. The closer together they are, the faster the pace.

5. The younger someone is, the longer it would take to notice.
It could take 10 years or more if young enough but will likely have early aging issues years ahead of when they otherwise would. That doesn't account an increasing pace of other infections or new variants.😵‍💫

6. Lastly that doesn't take into account persistent infections that may last years and quite possibly for life, like EBV or Herpes and other viruses. That increases the risks for autoimmune disorders.

researchsquare.com/article/rs-113…

Conclusion:
This is Unsustainable ⬇️

The big picture view keeps getting clearer and unless there are other undiscovered mechanisms at play, or new treatments, it's looking very bad for the let it rip/vaccine strategy.

Updated definition:
COVID: An increasingly more efficient, airborne disease that can cause accelerated aging & lymphopenia. COVID can lead to vascular, neurological, musculoskeletal, immunological & cognitive dysfunction and increases the risk of cancers and autoimmune disorders.