TACT Profile picture
Dec 22 6 tweets 4 min read
The single most important thing an individual can do to protect themselves and others is wear a quality N-95 mask properly. ⬅️

Make sure it's tight against your face & around your nose.

1.journals.sagepub.com/doi/pdf/10.117…

2.ncbi.nlm.nih.gov/pmc/articles/P…

#N95maskswork
#Maskswork
Layered Mitigation
"School administrators, teachers, and parents to provide the safest environment, it is important to utilize multiple mitigation strategies and contract tracing that reduce SARS CoV-2 transmission by at least 69%."

ingentaconnect.com/content/wk/phh…
It works best when everyone does their part to protect the rest of the community.

"Universal masking, in-person education was associated with low rates of secondary transmission, even with less stringent distancing and bus practices."

publications.aap.org/pediatrics/art…

#Maskswork
Home Mitigation Tips

1. Air purifiers with HEPA filters

2. Open a window from the top , in the room the infected person is in every few hours so the heat pulls the aerosolized respiratory droplets outside. Heat rises. The virus can remain viable in the air for at least 2 hours.
A layered mitigation strategy can be used effectively to limit in-school transmission, & at home transmission.

It won't work as well if the strategy doesn't include sufficient ventilation,
quality N-95/KN-95 masks, air-purifiers, & upgraded HVAC filtration.
#layeredmitigation
Help Advocate for
Clear Air for Kids
Email your local, state and congressional representatives.

Email the WhiteHouse

Join a state team to organize coordinated actions across the country.

We must do a better job of protecting our kids from viruses.

tactnow.info/clean-air-for-…

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More from @TactNowInfo

Dec 23
When people go to the hospitals we need clean air. Not diseases. Japan's data: Hospitals #1, 3rd for most outbreaks are schools. Upgraded HVAC systems that can filter out 99% of pathogens & maintain CO2 at 500ppm, are urgently needed in schools & hospitals.
Until then, we can ⬇️ ImageImage
We need new or upgraded HVAC that filters 99% of pathogens and can maintain a CO2 level of 500ppm. Until we then we can take additional steps to mitigate transmission of COVID, Flu, RSV and other airborne viruses. Image
COVID & AIDS are the leading cause of lymphocytopenia. This increases recurrent viral, bacterial or fungal infections and also increases the odds of cancers and autoimmune disorders.

msdmanuals.com/professional/h…
Read 23 tweets
Dec 21
🧵 Immune systems seriously weakened by COVID

"The virus depletes the body’s supply of T-cells, leaving young and old alike vulnerable to secondary infections, says a University of Waterloo immunologist." 1/

ncbi.nlm.nih.gov/pmc/articles/P…
"Individuals who are infected with COVID have many fewer T-cells,” said Katzenback who studies viruses.

“That’s a problem for us because T-cells are a really important part of our immune system that helps defend us against infection.” 2/
"Studies show COVID kills off a significant number of the body’s T-cells, so even when a someone recovers from COVID, they are at a heightened risk for other viral, bacterial & fungal infections."

Mucormycosis linked to immunity deterioration"

3/
onlinelibrary.wiley.com/doi/full/10.10…
Read 23 tweets
Dec 20
Japan has significantly less reinfections than the U.S.
& this ⬇️

“We can’t downplay the fact that 1 in 20 patients has some kind of symptoms after a month,” said Osaka University professor Satoshi Kutsuna

➡️“We call on people
to be careful not to
become infected” ⬅️ 1/
They found that 47.7% of the respondents suffered after effects, 5.2% saw those linger for at least 30 days and 3.7% continued to experience them for 60 days or more.

1.61% said they found difficulty performing daily activities, 1.41% experienced hair loss, 1.28% coughing. 2/
Remember this huge VA study from early in pandemic?
Study of 5.8 million people

41k with reinfection

444k with 1 infection (no reinfection)

5.3 million non-infected controls 3/
Read 13 tweets
Dec 20
"Worker productivity is falling at the fastest rate in four decades"

"The problem is not isolated to Benioff's company.: 2022 is the first year since 1983 when there's been three straight quarters of year-over-year drops in average productivity per worker." 1/
"Employees are working more and producing less, and a time when their financial stress is the highest it has been since 2008."

Why would productivity be declining and life expectancy declining? 🤔

cnbc.com/amp/2022/12/18…
Could it be the cognitive, immunological, & vascular, dysfunction from repeated COVID infections? 🤔
➡️ "SARS-CoV-2 infection and persistence throughout the human body and brain"

"COVID causes systemic infection and can persist in the body for months."

researchsquare.com/article/rs-113…
Read 5 tweets
Dec 19
"Immune cell dysregulation is a driver of COVID severity" (peer-reviewed)

"decreased total conventional DC (cDC), conventional type 2 DC (DC2), and plasmacytoid DC (pDC) (Fig. 2, C and D). CyTOF also showed lymphopenia of CD4 and CD8 T cell populations"

eurekalert.org/news-releases/…
An immunologist writing a peer-reviewed paper on immune dysfunction & lymphopenia.

Wish it weren't true but the good news is mild cases recover. The problem is how fast reinfections often occur.

Dr. Sacha Gnjatic received his PhD in Immunology from the University of Paris VII.
Paper on persistent infection in asymptomatic children's tonsils that may contribute to transmission,showed similar results.

Fig. 2 "Proteomic characterization of COVID serum reveals distinct immune patterns associated w/disease severity & clinical outcome."

#Immunedysfunction
Read 15 tweets
Dec 19
➡️ Until better vaccines and treatment become available, increasing population awareness, hygiene, mandating the use of face masks, restricting travel, & physical distancing could be the most successful strategies to manage the impact on economy & health care system. ⬅️. 1/
That's from a 2020 study. Unfortunately, almost back to where we started but w/millions dead, 10's of millions with long term disability,
100's of millions that will live shorter lives.
Vaccine efficacy ⬇️
Monoclonal treatments ❌️
Paxlovid,a few mutations away from ❌️
2/
The moral of the story:
Don't treat without first controlling transmission.
COVID evolves around targets of treatments quite efficiently. This was known over 2 years ago.

We essentially trained a virus how to beat our immune systems and still ongoing.
Great job, people. 🤬
Read 14 tweets

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