Daniel Horowitz Profile picture
Dec 29, 2022 10 tweets 2 min read Read on X
How the discovery of the shots causing more production of IgG4 as opposed to the other classes of antibodies might explain the negative efficacy of the shots conservativereview.com/horowitz-possi…
I spoke to Dr. Dan Stock, an Indiana family doctor who is one of the most brilliant immunologists i know. Here is how he explained the significance of class switch from IgG1-3 to IgG4.
When Antigens (Ag) bind IgG1-3 antibodies (Ab) they change shape and then can bind to a macrophage (MF) which takes the Ag-Ab complex into the MF (we call that Ab-mediated uptake opsonization).
But the Ab gives the MF different instructions depending on what type of IgG it is. IgG1-3 tell the MF “this is this or that type of pathogen, protect yourself from it and present it to the lymphocytes so they can make the proper response”.
The MF understands that it has a pathogen, changes its metabolism to make it less infectable, and shows it to lymphocytes with particular patterns of cytokines, which activates the proper immune response.
IgG4 binds an Ag and then is opsonized into MF but the MF is given the instruction “this is innocuous material, don’t protect yourself or activate the lymphocytes, just destroy it”. The MF processes the AG differently without protecting itself and becomes more infectable.
And it doesn’t tell the lymphocytes that they should respond. This is exactly what we saw happening late in the old RSV vaccine, and is another mechanism explaining ADE, in addition to the hypocellular immune response.
The MF becomes more easily infected, doesn’t signal a proper immune response and the infection goes further with more tissue destruction and inflammation than it would have it you hadn’t induced IgG4 production.
So yes, it explains the late-onset immune compromise that we’re seeing, if these shots induce IgG4 shifts, as we now know they do.
IgG4 transformation is part of developing what we call immune tolerance: Where the immune system recognizes a foreign protein but doesn’t mount a response to it. It’s a great thing to do against pollen. It’s a terrible thing to do against a virus.

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More from @RMConservative

Jan 18
I have said this for 20 years after we are saddled with RINOs in primaries - whether presidential or down the ballot. There is a middle ground between absolutely not supporting the RINO in the general vs. throwing yourself at the guys feet nearly a year in advance and not even attempting to pressure him to the right. To that end, those with influence over the lord savior have an obligation to get answers to this 6 questions. theblaze.com/columns/opinio…
1) How will Congress change? The simple fact is we’ve gone backward when it comes to winning primaries against the GOP establishment since 2016. In down-ballot races for Senate, House, and governor, Nikki Haley’s worldview is the rule, not the exception.

Milquetoast Republicans continue to win, often with Trump’s support. Every globalist incumbent appears on track for a bigger win in their primaries than Trump managed in Iowa.

What is the plan, if any, for Trump to change his endorsement practices? What is his plan as president to use must-pass bills and demand changes even at the risk of a government shutdown? Trump already told CNN he would only oppose raising the debt ceiling as a candidate, not as a president. Good to know! So what will change?

If anything, it is getting worse. He has endorsed rinos like Barrasso, Wicker, and Cramer who are in cycle in the coming weeks, yet is working against Bob Good, one of the most hard core members who actually beat a RINO in a primary who voted to impeach Trump.
2) How will Trump’s personnel change?

Name the competent anti-establishment figures who will join the next administration. Trump’s downfall was due to nearly every Cabinet pick embodying the attributes and worldview rejected by his base, from Treasury Secretary Steven Mnuchin to Defense Secretary James Mattis all the way down. Trump surrounds himself with the likes of Senator Lindsey Graham (R-S.C.) and Laura Loomer — and no, Loomer isn’t getting into the Cabinet.

During his victory speech on Monday, Trump stood side by side with North Dakota Governor Doug Burgum and suggested he would serve in a potential second-term administration. That would likely mean Burgum would land in the Department of Energy. Does Trump not know that Burgum is a stereotypical World Economic Forum politician who pledged in his last State of the State address to make North Dakota “carbon neutral”?

Burgum would have run as a Democrat in another state, but knew he had to run as a Republican in North Dakota. He bought himself a governorship by pretending to be one of us. Now, he might run for a third term. He has gone out of his way to oppose conservatives — mainly Trump supporters — in his state’s legislature. He is the type of politician Trump should target for defeat. Yet Trump wants to elevate him.

People with Trump’s ear should work to ensure that all the establishment hacks endorsing him in droves (and “saying nice things about him”) are not rewarded with prominent positions once again.
Read 8 tweets
Jun 29, 2023
Big but expected win on Harvard and UNC affirmative action for admissions. Court rules it violates the 14th amendment in both cases. 6-3
Thomas writes a 58 page concurrence! Cant wait to read. "I write separately to offer an originalist defense of the colorblind Constitution; to explain further the flaws of the Court’s Grutter jurisprudence; to clarify that all forms of discrimination based on race—including… twitter.com/i/web/status/1…
Closing line: "While I am painfully aware of the social and economic ravages which have befallen my race and all who suffer discrimination, I hold out enduring hope that this country will live up to its principles so clearly enunciated in the Declaration of Independence and the… twitter.com/i/web/status/1…
Read 7 tweets
Mar 31, 2023
Is this just about grifting and promoting one man or is this about shutting down political persecutions? Here are 7 actions we should demand from GOP govs and House members theblaze.com/op-ed/horowitz…
1) Fund legal defense of persecuted individuals: It’s extremely hard to even get a lawyer willing to fight the system. I personally had trouble finding people lawyers when fighting January 6 charges or businessmen being prosecuted for the “crime” of opening their stores during… twitter.com/i/web/status/1…
2) Refuse to extradite: Gov. DeSantis just set a precedent that Florida will not assist with extradition of those politically targeted. Other red-state governors should refuse to extradite people being accused of non-violent crimes when there is compelling evidence that other… twitter.com/i/web/status/1…
Read 8 tweets
Mar 31, 2023
Without the active assistance of a governor signing and expedition warrant, out of state cops cannot just come in and grab someone (and this is putting the Secret Service issue aside). DeSantis said he won't do it. People demanded that of him. So again, why is Trump going to NY?
You can't have it both ways. If it's important that DeSantis violate all legal norms (which Im in favor of if its in response to them violating the norms to begin with), then its important that Trump break the precedent and not show up.
I hear people suggest then he would be in legal jeopardy. But do would DeSantis if (in their hypothetical of NYPD somehow trying to come down) NY takes it to the federal courts and they issue an order. They want DeSantis to openly defy. Fine. But then Trump has to do his part.
Read 6 tweets
Dec 26, 2022
Let's put the jabs and paxlovid aside for a moment. Everyone agrees molnupiravir is crap, yet Merck got $2 billion and ran with it. It's approved to this very day. Now we know it causes mutations medrxiv.org/content/10.110…
"Within days of treatment, we detected a large number of low-frequency mutations in patients and that these new mutations could persist... All patients treated with the drug accrued new mutations in the spike protein of the virus"
"Our study demonstrates that this commonly used antiviral can ‘supercharge’ viral evolution in immunocompromised patients, potentially generating new variants and 25 prolonging the pandemic."
Read 4 tweets

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