Thread by @dirkwestermann

Very happy to see our #UNLOADECMO trial started in 12/22 with 4 patients already included.
#MCS therapy in cardiogenic shock still very challenging.
#ECLS-SHOCK (#ECMO)and #DanGer-Shock (#Impella) running already and will be finished soon.

What are we investigating?🧵1/6 below:

🧵2/6 @BenediktSchrage showed earlier that "LV Unloading Is Associated With Lower Mortality in Patients With CS Treated With VA-ECMO"
ahajournals.org/doi/10.1161/CI…

Large study (686 patients), but obviously not prospective and randomized. But that's needed in CS (and everywhere)

🧵3/6 Others @benhibbertMDPhD showed this as well in a meta-analysis @jaccjournals jacc.org/doi/10.1016/j.…

🧵4/6 or @reshadgaranMD @JNunezMD jacc.org/doi/abs/10.101…

🧵5/6 We will randomize patients with CS in need of ECMO to LV unloading with an #Impella on top of #ECMO vs. control (IABP unloading as bail out).
#ECPELLA vs #ECMO

🧵6/6 Next centers (up to 10 in 🇩🇪) will be initiated in 01/23. This will be a challenging endeavor to see whether #ECPELLA will be a winner in #CS. Will be presented by @BenediktSchrage in a couple of years ...
clinicaltrials.gov/ct2/show/NCT05…

@BenediktSchrage @UHZ_UNIFreiburg @seanvandiepen @Babar_Basir @gbiondizoccai @GreggWStone @krychtiukmd @Kardiophil @DGK_org @EuroELSO @ELSOOrg @PCRonline @JBauersachsMD @Lam3th @NavinKapur4 @SCAI @Abiomed @BurkhoffMd @YoungDgk @JJheart_doc @CardioNerds @BiykemB @FH_Verbrugge

@willsuh76 @mmamas1973 @Steph_Achenbach @UKEHamburg @Uniklinik_Fr @StefanKluge4 @imit_freiburg @yourICM @DIVI_eV @sulimov_dmitry @CVandenbriele @JumeanMarwan @MoritzSeiffert @FabianJBrunner @HFSA @DrMarthaGulati @docbhardwaj @JasonKatzMD @SebLudwig1 @Sticchi_Alex @ACVCPresident