Thread by @WesElyMD

1/🧵 Our cell’s genes are rewired in MILD COVID 🧬
 
Stunning data in @Nature
 
White Cells (monocytes) switch gene expression from an established innate immune profile to a pro-clotting signature in COVID.
 
We’re immunocompromised.

Let’s unpack this…
 
go.nature.com/3GeDygW

2/ These data explain how the COVID virus places our bodies at risk for macro (large) blood clots in acute dz (which we see often), brain disease due to down-stream micro-clotting, and possibly later cardiovascular dz.
 
What did these London investigators find?

3/ Taking blood from 2 UK SARS CoV2 studies…

📍They compared COVID🩸(N=62 mild/mod dz) to normal controls
📍Then conducted genetic, metabolic & functional assays
👀 Look how different gene expression was (color difference) in COVID vs. HC (healthy control) pts
 
What’s it mean?

4/ Monocytes of COVID pts display abnormal markers of inflammation & clotting that drives us to immuno-thrombosis & vascular platelet+cell aggregates.
 
Very scary stuff if you want a body & brain to get blood, food & oxygen normally.

I highlighted excellent discussion points👇

5/ Let’s pose some Important Questions:
 
✔️Are these findings COVID-specific?
✔️How long do these genetic/cell function changes last?
✔️Do they contribute to #LongCOVID?
✔️What’s the cost of repeat infections?

6/fin
Our innate immunity is being re-wired by COVID‼️

📌These systems protect us from severe disease & secondary infections
📌My spidey-senses tell me to stay as protected as possible
📌COVID XBB variant is spreading fast
📌Het your Bivalent Vaxx
 
go.nature.com/3GeDygW

Clotting isn’t specific to #COVID, it’s just more profound & longer lasting w this 🦠

I’ve been shocked in COVID by my patients clotting on full heparin drips.

In🧵👇I give examples & discuss data - it can happen w bacteria, but the pathology persists in #LongCOVID

https://twitter.com/WesElyMD/status/1600470718403133440

See tweets 12-14 in this 🧵 for specifics.