Thread by @GahbauerStefan

Our discovery of SARS-CoV-2 Macrodomain inhibitors is now published in @PNASNews!!!

🎯 160 hits identified through computational fragment-linking and virtual screening

💎 152 Xray crystal structures at atomic resolution

pnas.org/doi/10.1073/pn…

Big thanks to all co-authors including Galen, @fraser_lab, @BShoichet, @chem4biology, @matteoferla, @FrankvonDelft, @_MarionSchuller, @IvanAhelLab, @Ashworth_SF, @adamrenslo, @ysmoroz and @EnamineLtd.

Here's a more detailed thread that we posted with the preprint:

https://twitter.com/GahbauerStefan/status/1541924168785993729

It's exciting to see that Mac1 was chosen for the 3rd #CACHEChallenge hosted by @thesgconline, @aledmedwards, @mattschap. I hope this work will help all partitioning groups! Good luck!!!