When I discuss ways to improve lab safety in academia, I present parts of this review by @TrantTeam and @Shufflersunite. The paper discusses the current state of academic lab safety, supported by data (yay!), and concludes with stressing the need for 1/8
…Support from leadership in order to minimize future laboratory incidents in academia.
Some of my favorite (and most concerning) pieces of data discussed are: 2/8 #chemtwitter#labsafety#chemsafety
“In one survey from Nature and UCLA, 30% reported having witnessed a lab injury severe enough to warrant attention from a medical professional”
🤯 These incidents are rarely reported and could potentially be much larger
3/8
“In 2016, [it] was found that only 8% of the 726 chemistry journals they identified required safety factors to be mentioned in the manuscript”.
Big pet peeve of mine here. Any method claiming to be a safe alternative needs data to back it up. Rarely, if ever, done. 4/8
“27% of participants, active experimental researchers, stated they never conducted a risk assessment”
I bet this is is way lower. RAs are essential and rarely taught in chemistry but are more common in engineering programs. 5/8
If you don’t know how to use the risk matrix in the previous tweet or understand the hierarchy of controls (below) then your ability to perform an effective RA is questionable 6/8
Another finding in the Menard and Trant paper: “…found that only 40% of participants and academic researchers reported wearing PPE at all times” 😡
Not wearing PPE in industry could result in termination. Get in the habit early! 7/8
Every new, mid-career, and full professor needs to read the paper and fully digest the data presented. They also need to ensure they are doing everything they can to protect the students working in their labs. This includes education and training in lab safety 8/8
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Here’s a few reasons why process chem tries to avoid chrom in early development, ESPECIALLY for the API. Yes there will be exceptions, but for the most part these points hold true …1/n
The first relatively large batch made by process chemists has different names depending on the company. At PFE we called it the regulatory tox batch, at VRTX it’s the GLP tox batch. This is the first time your chemistry will be done on multikilo scale 2/n
A typical batch size can range from 500g up to 4+ kg. When I was making material for ADCs the batch size was <5g. Again, it’s all about the projected dose before tox findings. So why do we avoid chrom like the plague (well like the bubonic plague anyway)? 3/n
It’s never too early to begin prepping for the 2021 hiring season. Many companies post open positions in Q1/Q2 having budgets approved for that fiscal year. For anyone looking to make the leap into pharma/biotech here are a few points to consider: @Chemjobber#chemtwitter
1) There are a lot of awesome companies that do amazing science. Company size does not determine quality of science. Be willing to look at big, medium, and small startups. Each will have a different culture. Find one that not only pays the bills, but makes you proud to work there
2) Tailor your CV to the role you are applying to. If the job lists experience needed with catalyst/ligand screening your PhD was in this area, make sure the experience you list matches keywords in the job post. 1000s of CVs will be prescreened. Make sure yours gets through