🇦🇹 Representative genomic surveillance of SARS-CoV-2 in Austria week 2, 2023 across all regions. Current analysis includes samples until January 5th allowing faithful nowcasting. A collaboration of #AGES@agesnews and @IMBA_Vienna/@oeaw. 1/5
The variant situation for Austria changed dramatically between the years. While we had a swarm of lineages growing in numbers until Christmas, it is now just one lineage showing growth: XBB.1.5. 2/5
XBB.1.5 is a descendent of the strongly immune evasive recombinant XBB that now acquired a mutation improving binding to the ACE2 receptor on human cells and thereby infectivity. It is observed across Austria now. Nowcasting predicts it to be currently at ~8%. 3/5
Low numbers still make assessment of growth imprecise, but in alignment with international data we see roughly a doubling every week predicting this lineage to become dominant in February and in all likelihood subsequently driving a wave of infections. 4/5
The fraction of Influenza A positive Covid patients has fallen to just below 2% and might increase again with the end of the holiday season now. 5/5
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🇦🇹 Representative genomic surveillance of SARS-CoV-2 in Austria. This is our analysis run number 100, so I would like to start by thanking the entire SARSeq team. One hundred successful analysis rounds straight is an amazing achievement, congratulations to everyone! 1/
This collaboration of health authorities and academia showcases the innovative power and value of academic institutions that stepped in in response to the pandemic. Globally such solutions were rather the rule than the exception, so big shoutout to all my colleagues worldwide!
3/
Important work on the wild reservoirs of SARS-CoV 1 and 2 and a new SARS-CoV-SARS-CoV-2 recombinant in a paper that just went online summarized here 🧵: biorxiv.org/content/10.110…
1/11
Yunnan Province at the southern tip of China is a hotspot for bats and bat viruses. Closest relatives of SARS-CoV as well as SARS-CoV-2 are found here and different bat species are living in caves together.
2/11
In this important work, researchers analyzed 149 bats individually to study what virus they carry and found 41 different ones, 70 bats were positive for at least one virus (47%), amongst them 1.5 viral species were found on average per individual.
3/11
🇦🇹 Representative genomic surveillance of SARS-CoV-2 in Austria in week 42 across all regions. Nowcasting in dashed box shows the current situation. A collaboration of #AGES@agesnews and @IMBA_Vienna/@oeaw. 1/6
BA.5 with R346T has reached ~25% now. New variants such as BQ.1(.1) and XBB show clear growth. BQ.1(.1) currently at ~8%, XBB<1%. 2/6
Due to the good weather (see journals.plos.org/ploscompbiol/a…) and declining case counts of BA.5 we currently observe a strong reduction in absolute numbers. 3/6
🧵To mask or not to mask, this is the question again.
With winter starting in the northern hemisphere, masks are discussed many places. Some thoughts within the range of realistic options:
A.For societies
B.For individuals
A. Any form of enforced mask mandate as seen in some countries previously of course is a stress test for societies and generally disfavoured by most, but also requested by many. Some arguments for society level reactions:
A.1 One might argue that dampening one wave with masks just means the next wave is higher. Connected vessels. Only true however if we assume that one wave generates immunity against the next, this was neither true always in the past nor is it projected to be the case this winter.
Currently there is a trend towards convergent evolution in SARS-CoV-2. But is that the whole picture? All roads to Rome and that’s it? Or where do we go from here?
My 2 cents in an illustrated 😊 thread…. 1/
We have built a polyclonal B-cell immunity to counteract a SARS-CoV-2 infection, that we all cherish. But as we get closer to the edge of it, mutations in the spike protein gain more advantage to escape that defense. 2/
With the initial variant this was less likely to occur, but with BA.1 and even more so BA.2 there is more immune erosion and drops get more frequent. Modified from this wonderful study. biorxiv.org/content/10.110… 3/
Looking like with the latest turn of direction the virus has managed to escape our immune system efficiently yet again.
There is an unprecedented number of highly diverged variants coming up and two brand-new studies shed light on this concerning situation.
Amazing work! 1/
In one study, Ben Murrell and colleagues show five-fold escape from serum neutralization by BA.2.75.2 in pseudovirus assay. biorxiv.org/content/10.110…
2/
In another very impressive study, Xiaoliang Sunney Xie and colleagues study many current sub-sub variants comprehensively. 3/ biorxiv.org/content/10.110…