Keith Hornberger Profile picture
Jan 20, 2023 11 tweets 5 min read Read on X
I’m going to offer some more regular industry #EarlyCareer tips on Fridays. Keeping this focused on chemistry in pharma since that’s what I know about.

Let’s start with applying for the job! 🧵 👇 1/
First off, unlike many other lines of industry work, in pharma chemistry we usually ask for a comprehensive academic-style curriculum vitae (CV) rather than a shorter résumé. Sometimes these terms get used interchangeably in the US, but they’re not the same. 2/
This removes some pressure to compress your professional life into a page or two. A CV typically includes: contact info, work history (most recent first), educational history (most recent first), complete publications & presentations, and possibly other optional sections. 3/
Most important here are the work and educational history. Usually you’ll want to include a couple of bullet points with each step in your journey describing your most important accomplishments. These can (should) be tailored to the description of the role you’re applying for. 4/
Read the job description. If it’s a bench position, play up your lab skills. If it’s a design position, play up analysis and reasoning. The first thing a recruiter looks for is a sense of fit to what the role requires. Don’t assume your CV speaks for itself; infuse it intent. 5/
Use active verbs that clarify what you did (designed, synthesized) and avoid passive verbs that obscure (participated, worked, studied). Here’s a reference (there are many) on verb usage. 6/
rezi.ai/posts/weak-act…
Emphasize transferable skills. Almost never is your academic work experience going to exactly match what pharma chemistry is hiring for. So show that you’ll pick up the stuff we’re going to teach. Ex: show you can solve problems & overcome setbacks - those are universal. 7/
A CV can still be a bit confining to convey all of that essence in a few bullet points, so it’s also worth writing up a 2-3 page narrative research summary. Companies won’t always ask for one, but sneak it in on the back of your CV or cover letter anyway. 8/
A research summary is where you can really unspool those transferable skills. Show your thought process. Show *how* you did the work and got past all the places where you were stuck. Remember, we’re hiring *you*, not your work. 9/
Above all, and throughout, show the recruiter what kind of scientist you are. Don’t assume the work speaks for itself — it doesn’t. It’s up to you to infuse your work with your own voice and show why you’ll be a great colleague. The “how” matters just as much as the “what”. /end
Tacking this on as a PS. Need to hear what you did, not what the team did. Otherwise how do I know it wasn’t someone else on the team? Maybe I should hire them instead! 😂

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More from @KRHornberger

Jan 18
Jensen Huang’s comments from JPM24 are now summarized in a Nvidia blog post. He doubles down on exactly the kinds of things that I’ve been cautioning are wildly optimistic. More below. 👇🏽 1/ Image
Usual disclaimer: it’s op-ed time again. My opinions alone, not my employer’s or anyone else’s. 1.5/
For reference, here’s the summary. 2/
blogs.nvidia.com/blog/nvidia-ce…
Read 16 tweets
Sep 15, 2023
Time for another pharmacology tweetorial on another layer of the selectivity problem: drug promiscuity. Both the things we can control, and the things that are out of our hands thanks to good ol’ Mother Nature. 1/ Buzz and Woody meme. Polypharmacology, polypharmacology everywhere
Usual disclaimer: all thoughts and opinions in this post are my own, and don’t necessarily reflect the opinions of my employer. This thread will feature a higher proportion of opinion than normal, but with reasoning supplied. 2/
This is a coda to the last tweetorial on receptor occupancy and selectivity. Have a gander here. 3/
Read 23 tweets
Sep 10, 2023
Time for another pharmacology tweetorial (X-torial?), this time on the subject of receptor occupancy and how it relates to selectivity. 1/ Brain awake meme: Remember that selectivity data you got on your compound? Yep all good It’s not telling you what you think it is *eyes open*
Usual disclaimer: all of this thread is my own thoughts and opinions on the subject, and does not necessarily reflect the views of my employer. Your mileage may vary. Some restrictions may apply. 2/
References first. For an excellent primer on pharmacology in general, which also covers the concept of occupancy extensively, you’ll want to check out this book by my old GSK colleague Terry Kenakin. Chapter X is especially relevant. 3/
sciencedirect.com/book/978032399…
Read 41 tweets
Mar 17, 2023
Continuing the occasional Friday pharma #EarlyCareer series. Last time we talked about site interviews. This time let’s talk about negotiating job offers. (Next time we’ll deal with the inevitable rejections.) 🧵 1/
Usual disclaimer: everything in this thread is my observations based on 20+ years of personal experience at pharmas big and small, and should not be construed as reflecting the opinions and practices of, nor an endorsement by, my employer. 1.5/
After a site interview, it’s typical for a job offer or “no thanks” to follow within a few weeks. Allow some time here as more than one person is often being interviewed for a position. If you have time pressure (competing offers), the sooner you tell the company, the better. 2/
Read 26 tweets
Feb 24, 2023
Continuing the Friday pharma industry #EarlyCareer tip series. Last time we talked about phone interviews. This time let’s talk about the next step, a really big one: on-site interviews. 🧵 1/ The Most Interesting Man in the World: I don’t always go o
If your phone interview goes well, the hiring manager will usually invite you for a site interview. Pre-pandemic, that almost always meant traveling to the pharma R&D site for the interview. These days, it may also be done virtually on Zoom or Teams instead. 2/
If you require accommodations for any reason, give the hiring manager or HR person a heads-up before the interview. Most companies are happy to work with you on this if they know. If they won’t, that’s a red flag. Consider then whether or not it’s worth going forward. 3/
Read 30 tweets
Feb 10, 2023
Since we’re all watching The Last of Us, is it really true that we have nothing (other than bombs) for the coming fungal pandemic? Time to review what we’ve got in the pharmacopeia for fungal infections. Lest we all turn into zombies. 🧵 1/
Broadly, antifungals are woefully under-researched, even among anti-infectives. Fungi are more similar to animals than plants or bacteria. That relative same-ness means finding drugs that target fungi without targeting ourselves is tough. And resistance is ever on the rise. 2/
There are three big main classes of antifungal (or anti-mycotic) agents. Two of those three lean on the fact that fungi make use of ergosterol as the main sterol in their cell membranes rather than the cholesterol typically found in animals. 3/ Chemical structure of ergosterol, (1R,3aR,7S,9aR,9bS,11aR)-1
Read 20 tweets

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