I’m going to offer some more regular industry #EarlyCareer tips on Fridays. Keeping this focused on chemistry in pharma since that’s what I know about.
Let’s start with applying for the job! 🧵 👇 1/
First off, unlike many other lines of industry work, in pharma chemistry we usually ask for a comprehensive academic-style curriculum vitae (CV) rather than a shorter résumé. Sometimes these terms get used interchangeably in the US, but they’re not the same. 2/
This removes some pressure to compress your professional life into a page or two. A CV typically includes: contact info, work history (most recent first), educational history (most recent first), complete publications & presentations, and possibly other optional sections. 3/
Most important here are the work and educational history. Usually you’ll want to include a couple of bullet points with each step in your journey describing your most important accomplishments. These can (should) be tailored to the description of the role you’re applying for. 4/
Read the job description. If it’s a bench position, play up your lab skills. If it’s a design position, play up analysis and reasoning. The first thing a recruiter looks for is a sense of fit to what the role requires. Don’t assume your CV speaks for itself; infuse it intent. 5/
Use active verbs that clarify what you did (designed, synthesized) and avoid passive verbs that obscure (participated, worked, studied). Here’s a reference (there are many) on verb usage. 6/ rezi.ai/posts/weak-act…
Emphasize transferable skills. Almost never is your academic work experience going to exactly match what pharma chemistry is hiring for. So show that you’ll pick up the stuff we’re going to teach. Ex: show you can solve problems & overcome setbacks - those are universal. 7/
A CV can still be a bit confining to convey all of that essence in a few bullet points, so it’s also worth writing up a 2-3 page narrative research summary. Companies won’t always ask for one, but sneak it in on the back of your CV or cover letter anyway. 8/
A research summary is where you can really unspool those transferable skills. Show your thought process. Show *how* you did the work and got past all the places where you were stuck. Remember, we’re hiring *you*, not your work. 9/
Above all, and throughout, show the recruiter what kind of scientist you are. Don’t assume the work speaks for itself — it doesn’t. It’s up to you to infuse your work with your own voice and show why you’ll be a great colleague. The “how” matters just as much as the “what”. /end
Tacking this on as a PS. Need to hear what you did, not what the team did. Otherwise how do I know it wasn’t someone else on the team? Maybe I should hire them instead! 😂
Time for a pharmacology tweetorial (of sorts) on one-eyed sheep. It’s an odyssey that began on Idaho ranches in the 1950s and ended over half a century later with the approval of several new cancer drugs for basal cell carcinoma and AML. 1/
Usual disclaimer: all opinions expressed herein are my own, and do not necessarily reflect the opinions of my employer. Nor am I a medical doctor slinging any medical advice. Any errors or omissions are because I’m just a simple chemist. 2/
In the mid-1950s, Idaho ranchers reported that lambs were being born with severe & fatal birth defects, the most visible of which was cyclopia (one eye). This problem had been going on for a long time and was presumed to be genetic. 3/ pubmed.ncbi.nlm.nih.gov/13630801/
Time for another pharmacology tweetorial, this time a second installment on structural alerts. We’ll cover more things about anilines and phenols beyond redox cycling. We’ll also talk about glucuronides generally and a reactive subset (acyl glucuronides) specifically. 1/
For a refresher, please first take a gander at this first thread on structural alerts, where I talked in depth about redox cycling. A lot of these concepts will reappear and be further elaborated upon here. 2/
Let’s start with anilines. Anilines are, as a class, one of the most-remarked-upon structural alert features. Details (and some subtleties) can be found in the review below. 3/ eurekaselect.com/article/63367
More about “leaving academia”. Even the language of “leaving” is biased and implies that: 1) if there were just more academic jobs, then *of course* everyone would stay; 2) academia is the pinnacle job. None of this is true. 1/7
Most PhDs will pursue non-academic careers. That’s the default state.
Certain folks in academia: (sotto voce) Well, obviously the *best* ones are the ones who stay.
Everyone else: You know it’s just because there’s more jobs available in other employment sectors, right?
2/7
We all have to pass through the halls of the academia before our careers. But that’s education, not a career. What a mind job the academy has done — willfully or passively — by building a false narrative that makes people feel this sense of defeat for going elsewhere. 3/7
Time for another pharmacology tweetorial, this time on structural alerts (part 1: redox cyclers) – or broadly speaking, why medicinal chemists don’t like to work with certain functional groups if they can help it. 1/
Usual Disclaimer: this thread represents my own views and opinions, not necessarily those of my employer. 1.5/
A structural alert is broadly defined as a structural feature of a drug molecule that can be mechanistically connected to an adverse clinical event, whether that be toxicity, mutagenicity, carcinogenicity, or the like. 2/
Time for another pharmacology tweetorial, this time on irreversible inhibitors, their biochemical characterization, and their chemical optimization. 1/
References first. There are lots of papers and reviews on this topic, but a cogent and relevant one is this one by Strelow. Not the only articulation of k_inact/KI ratios out there, but it’s a really good one. 2/ journals.sagepub.com/doi/full/10.11…
I also enjoyed this recent book chapter by McWhirter, which delves a little more deeply into the math, but in a relatively accessible way (for a chemist!). Also lots more details on experimental techniques. 3/ sciencedirect.com/science/articl…