Tommaso Scquizzato, MD Profile picture
Jan 22, 2023 6 tweets 5 min read Read on X
4 RCTs published in the last few hours you can’t miss if you work with critically ill patients:

#1 Fluids in septic shock
#2 Mobilisation and long-term cognitive impairment
#3 NIV for extubation of obese patients
#4 Nutrition before extubation

A thread 🧵👇

#FOAMcc #SCCM2023
#1

#CLOVERStrial compared a restrictive fluid strategy (with early vasopressors) to a liberal one in septic shock patients.

➡️ Restrictive fluid strategy (with early vasopressors) did not result in significantly lower (or higher) mortality

🔗 nej.md/3CWSXBA

#FOAMcc
#2

What’s the effect of early mobilisation on long-term cognitive impairment in ICU survivors after mechanical ventilation?

➡️ Early mobilisation improved long-term cognitive impairment at 1 y (24% vs 43%) but increased adverse events (6%)

🔗 bit.ly/3CYIZQ7

#FOAMcc
#3

Does NIV (alternated with HFNO or standard O2) reduce treatment-failure in obese ICU pts undergoing extubation compared to HFNO or standard O2 alone?

➡️ NIV reduced treatment failure (e.g., reintubation) within 3 days after extubation

🔗 bit.ly/3QQg8mM

#FOAMcc
#4

Does continued enteral nutrition vs fasting (max gastric vacuity) before extubation reduce extubation failure (reintubation or death) within 7d in ICU pts?

➡️ Continued enteral nutrition until extubation was non-inferior to a 6 h fasting

🔗 bit.ly/3kqTup5

#FOAMcc
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More from @tscquizzato

Feb 3
TOP, MUST-READ CARDIAC ARREST TRIALS OF 2023 🫀⚡️

We summarized in this infographic 4 important multi-center RCTs published in 2023 in the fields of cardiac arrest and CPR

Concomitantly published with a concise review in @ResusJournal

🔗

🧵1/4

#FOAMcc sciencedirect.com/science/articl…
Image
@ClaudioSandron3 @jas_soar @ERC_resus @erc_young @JerryPNolan @CritCareReviews @NickJohnsonMD @nickmmark @expensivecare @iceman_ex #1

The #INCEPTIONtrial

First multi-center RCT on #ECPR from The Netherlands 🇳🇱

➡️ ECPR and conventional CPR had similar survival with good neurological outcome at 30 days (20% vs 16%, P=0.52) and at 6 months

🔗 @NEJM

#FOAMcc nejm.org/doi/full/10.10…

Image
@HansvanSchuppen @EduardArgudo @Pipes_n_pumps @laertezz @HawkmoonHEMS @ECMOdaily #2

The #TAMEtrial

🩸 Does mild hypercapnia (50-55 mmHg) vs normocapnia (35-45 mmHg) improve outcomes in OHCAs admitted to the ICU?

➡️ No difference in survival with good neuro outcome and mortality at 6 months

🔗 @NEJM

#FOAMcc nejm.org/doi/full/10.10…

Image
Read 5 tweets
Nov 5, 2023
🫀👀 Looking into the heart of the problem of refractory cardiac arrest

How coronary occlusion severity impacts the responsiveness of OHCA patients to resuscitation is a growing area of interest, fueled in these years by the use of ECPR that allowed previously unrecoverable patients to survive

🔗🧵 Read our editorial & thread /11
Image
@ClaudioSandron3 @ResusJournal @jas_soar @Pipes_n_pumps @EduardArgudo @krychtiukmd @DrCheskes @precordialthump @laertezz @expensivecare 2/

CAD is the leading underlying triggering factor of OHCA but likelihood of acute coronary occlusion is highly variable across OHCA patients

>20 years of research have shown that prevalence is highest in shockable rhythm+STEMI and lowest in non-shockable and no STEMI

👇
Image
3/

Refractory OHCA/ECPR patients have rates of significant CAD and identifiable culprit lesion comparable to patients with early ROSC

However a distinctive factor in refractory OHCA is the higher prevalence of left main coronary artery involvement and acute coronary occlusion
Image
Image
Read 13 tweets
Jun 10, 2023
WHAT ARE THE FINDINGS OF CAG AFTER OHCA?🫀

We performed a SRMA of 128 studies (>62k pts) to describe angiographic features in resuscitated and refractory OHCAs

We found that
🔸 significant CAD is present in 75%
🔸 CAD is more severe in refractory OHCA
🔸 CAD is common also in… twitter.com/i/web/status/1… Image
@giovannilandoni @NickJohnsonMD @expensivecare @Pipes_n_pumps @EduardArgudo @CritCareReviews @jas_soar @krychtiukmd @PabloJ @proftomquinn 2/

Although the high frequency of CAD in OHCAs is well known and numerous studies were published, use and findings of CAG are variable and often described only in some subgroups of patients

Type/frequency of coronary lesions in OHCA pts were not summarized before

#ResusTwitter
@giovannilandoni @NickJohnsonMD @expensivecare @Pipes_n_pumps @EduardArgudo @CritCareReviews @jas_soar @krychtiukmd @PabloJ @proftomquinn 3/

We conducted a systematic review with meta-analysis of proportions combining CAG findings from 128 studies (62k patients), including refractory OHCA

Nine subgroups were analyzed for a more accurate description of CAG use and findings

📄 resuscitationjournal.com/article/S0300-… #ResusTwitter Image
Read 18 tweets
Mar 16, 2023
🔸ECPR improves survival with good neuro outcome🔸

We just published the first meta-analysis of 4 RCTs

➡️ More OHCA patients had good neuro outcome when randomized to #ECPR (27% vs 18%, p=0.02)

🧵 Learn more in the thread /11

🔗 onlinelibrary.wiley.com/doi/full/10.11…

#FOAMcc #ResusTwitter
2/

In refractory OHCA, VA-#ECMO during ongoing CPR, known as #ECPR, can restore and maintain organ perfusion limiting brain injury

Growing evidence suggest that this approach can improve survival and neuro outcome

#FOAMcc #ResusTwitter
3/

After decades of evidence from non-RCTs, 3 single-center RCTs investigated #ECPR vs conventional CPR and 2 suggested a potential benefit

In 2023, the first multi-center RCT (INCEPTION) was published and showed no major differences in outcomes

#FOAMcc #ResusTwitter
Read 12 tweets
Jan 21, 2023
ECPR for OHCA: Pre-hospital or in-hospital?

Happy to share this Editorial written with @Alice_hutin and @giovannilandoni commenting on a SR/MA by @nattiejpk investigating the role of pre-hospital #ECPR.

🧵👇 Learn more in the thread /17

🔗 bit.ly/3ZQQNNG #ResusTwitter
2/

#ECPR is the last rescue therapy when despite high-quality conventional CPR it is not possible to achieve ROSC.

In such situations, OHCA is considered refractory and E-CPR recently demonstrated to improve outcomes in selected patients.

#ResusTwitter
3/

@nattiejpk recently conducted a SRMA published on @JCVAonline investigating effect of preh initiation of #ECPR on low-flow and survival

Most evidence comes from Paris, first EMS applying preh ECPR since 2011 @LionelLamhaut @alice_hutin

#ResusTwitter
Read 18 tweets
Jun 16, 2021
THREAD and my infographic of the #TTM2 trial

#OHCA patients were randomised to #TTM at 33°C or normothermia (<37.8°C) with early fever treatment.

➡️ Mortality and poor neuro outcome at 6 months were not lower in the hypothermia group.

🔗 nejm.org/doi/full/10.10… #FOAMcc Image
Guidelines recommend selecting and maintaining a constant target #TTM between 32 and 36 °C in comatose post-cardiac arrest patients to prevent hypoxic-ischemic brain damage.
(strong recommendation, moderate-quality evidence). #FOAMcc Image
Two RCTs published in 2002 showed an improved survival and neurologic outcome in patients resuscitated from OHCA of presumed cardiac cause and shockable rhythm who underwent hypothermia at 33°C. #FOAMcc Image
Read 6 tweets

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