👉developed purplish discoloration of his face after he underwent stenting and balloon dilation of the left CCA
What is the name of this finding?
Cutis marmorata
Harlequin syndrome
Livedo racemosa
Livedo reticularis
Telangiectasia
Shivering, sweating, and confusion developed immediately after artery dilation,
👉along with a left gaze preference, dysarthria, and hemiparesis on the right side of his body
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Over the next 20 minutes, livedo reticularis developed on the left side of his face
An embolic protection device had been used during the procedure
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Digital subtraction angiography
👉 patent left internal carotid artery
👉 an occluded distal left facial artery
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No intracranial hemorrhage was seen on CT of the head
👉 transferred to the (ICU),
👉 MRI and angiography of the brain revealed
👉 infarctions in the territory of the lt middle cerebral artery with patent vasculature
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An acute embolic stroke and cholesterol embolization syndrome of the face were diagnosed
An embolic protection device had been used during the procedure
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Digital subtraction angiography
👉 patent left internal carotid artery
👉 an occluded distal left facial artery
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No intracranial hemorrhage was seen on CT of the head
👉cholesterol embolization syndrome, atherosclerotic plaque contents from large-caliber arteries embolize to smaller arteries
👉 lead to vascular occlusion, inflammation, and end-organ damage
Livedo reticularis is one of the most common skin manifestations of the syndrome
♦️
👉 received supportive care in the IC
👉 livedo reticularis resolved 1 week after the event
👉 neurologic deficits persisted at the time of his discharge from the hospital 2 months later.
Differential cyanosis in a patient with patent ductus arteriosus, severe PH, and right to left shunt (Eisenmenger syndrome).
Note the severe clubbing and cyanosis of the toes as compared to the lesser degree of clubbing and cyanosis of the fingers
Differential cyanosis
●A difference of at least 5% in oxygen saturation (O2 sat) or 20 mm Hg in partial pressure of oxygen (Pao2) between the arms and legs
●Can be a sign of a patent ductus arteriosus (PDA), persistent pulmonary hypertension of the newborn (PPHN), or left-heart abnormalities
■A rare variation of differential cyanosis is called reverse differential cyanosis, where the upper extremity oxygen value is less than the lower extremity oxygen value.
*This is most often associated with dextrotransposition of the great arteries (dTGA) with coarctation of the aorta/interrupted aortic arch or with PPHN
A 20-wks pregnant patient is admitted to ICU with septic shock.
Culture reveals listeria.
The patient is known to have had severe anaphylactic reactions to penicillin
What is the drug of choice for this patient?
A) TMP-SMX
B) Clindamycin
C) Vancomycin
D) Ciprofloxacin
Answer:
A) TMP-SMX
In immunocompromised patients, including pregnant women, listeriosis can present as life-threatening sepsis and/or central nervous system (CNS) infection (invasive infection).
In this clinical setting, the mean incubation period is 11 days.
The manifestations of CNS infection include
meningoencephalitis,
cerebritis,
rhombencephalitis (infection and inflammation of the brain stem),
brain abscess, and
spinal cord abscess
●The first line of drugs in severe Listeriosis is ampicillin (or penicillin).
●Some experts add gentamicin, it is not advisable due to its potential toxicity.
●Trimethoprim/sulfamethoxazole (TMP-SMX), is the drug of choice if a pati
nt is PCN allergic.
●Unfortunately, this should be avoided in the first trimester and the last month of pregnancy.
●In the first trimester, this affects folic acid metabolism, and in the last month, it may cause kernicterus in the fetus.
●In those periods, meropenem can be used.
●This patient is way out of those risk periods for the drug, so the answer is A.
●Vancomycin has been proposed, but the failure rate is very high.