π CoVariants.org Update! π
23A (XBB.1.5) is now available on CoVariants! It's visible as part of Per Country & Per Variant plots, on the shared mutation page - and of course, has a page of its own.
1/9
#XBB15 #23A
23A (XBB.1.5) is now available on CoVariants! It's visible as part of Per Country & Per Variant plots, on the shared mutation page - and of course, has a page of its own.
1/9
#XBB15 #23A
This is in line with the recent addition of 23A (XBB.1.5) as a @nextstrain clade - read more on that below ππ»!
2/9
2/9
https://twitter.com/nextstrain/status/1623723987707564034
As I covered earlier, 23A (XBB.1.5) is descended from the recombinant 22F (XBB) variant, with some additional mutations. You can read more about how it evolved & acquired those mutations below ππ».
3/9
3/9
https://twitter.com/firefoxx66/status/1611387920207708163
On the 23A page, you can read about some initial 23A (XBB.1.5) work on neutralizing titres, see a list of defining mutations, a plot of the variant growth, link to Aquaria protein viz, & see a list of other mutations present in the variant.
4/9
#XBB15
covariants.org/variants/23A.Oβ¦
4/9
#XBB15
covariants.org/variants/23A.Oβ¦
There's also a link to the 23A (XBB.1.5) @nextstrain focal build:
nextstrain.org/groups/neherlaβ¦
Here, we can zoom in on the clade & get a closer look at how 23A sequences are distributed around the world, & their diversity. ππ
5/9
#XBB15
nextstrain.org/groups/neherlaβ¦
Here, we can zoom in on the clade & get a closer look at how 23A sequences are distributed around the world, & their diversity. ππ
5/9
#XBB15
On the Per Country page, 23A (XBB.1.5) is already clearly visible in the USA, Canada, UK & Israel, & is starting to appear in smaller numbers in other countries, like Germany & Singapore. Remember, sequencing data is always a few weeks behind.
6/9
covariants.org/per-country
6/9
covariants.org/per-country
Finally, on the Shared Mutations page, you can see how 23A's / XBB.1.5's Spike mutations compare to other VoC, including its Omicron family and 22F (XBB) parent.
7/9
covariants.org/shared-mutatioβ¦
7/9
covariants.org/shared-mutatioβ¦
More information on 23A (XBB.1.5) & its spread will become available in due course.
As always, CoVariants.org is open-source & we welcome your PRs & suggestions to add more studies & information to variant pages! (Or any error-catching!)
github.com/hodcroftlab/coβ¦
8/9
As always, CoVariants.org is open-source & we welcome your PRs & suggestions to add more studies & information to variant pages! (Or any error-catching!)
github.com/hodcroftlab/coβ¦
8/9
As before, I've created a file for 23A (XBB.1.5) mapping all defining mutations (relative to ancestral), including nuc->AA. This is available on the CoVaritants Github!
Huge ππ»to all who helped check it! (Esp @CorneliusRoemer @AngieSHinrichs)!
github.com/hodcroftlab/coβ¦
9/9
Huge ππ»to all who helped check it! (Esp @CorneliusRoemer @AngieSHinrichs)!
github.com/hodcroftlab/coβ¦
9/9
Apologies - that last link to the defining mutations machine-readable file is going to 22F not 23A! Here's the right one: github.com/hodcroftlab/coβ¦
And sorry for any confusion!
10/9
And sorry for any confusion!
10/9
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