Continuing the Friday pharma industry #EarlyCareer tip series. Last time we talked about phone interviews. This time let’s talk about the next step, a really big one: on-site interviews. 🧵 1/
If your phone interview goes well, the hiring manager will usually invite you for a site interview. Pre-pandemic, that almost always meant traveling to the pharma R&D site for the interview. These days, it may also be done virtually on Zoom or Teams instead. 2/
If you require accommodations for any reason, give the hiring manager or HR person a heads-up before the interview. Most companies are happy to work with you on this if they know. If they won’t, that’s a red flag. Consider then whether or not it’s worth going forward. 3/
If travel is involved, usually you won’t be thrown to the wolves to make your own travel arrangements. An administrative assistant will reach out to help you with transportation, hotel arrangements, etc. (If they don’t, that company’s culture is: you’re on your own!) 4/
Companies usually pick up the tab on travel costs up front, or offer reimbursement. They’ll also offer an allowance for incidentals, such as getting a snack at your hotel or an Uber ride. They don’t want financial barriers to discourage the candidate from interviewing. 5/
For a truly “on site” interview, you may be invited out to dinner the night before the interview. While it’s relaxed and social and a chance to meet more people, remember it’s still part of the interview! They’ll be assessing how easy you are to get along with as a teammate. 6/
Clarify at dinner how you’re arriving at the site the next day: drive yourself, Uber, or is your host picking you up? Turn in early and get a good night’s sleep, you’ll need it! Be on time in the morning. The rest of the thread applies whether you’re in person or virtual. 7/
A site interview is usually a full day for PhDs (maybe a half day for BS/MS folks), and you’ll be tired by the end. (Virtual might be broken up over >1 day though as scheduling allows.) Take bio breaks, coffee breaks, snack breaks — keep your energy up, it’s a long day! 8/
Attire: there are different schools of thought on this. Imo the best thing to do is to ask your hosts what their norms are. Some companies are casual, some formal, so don’t assume. In the absence of this info, lean formal. You can’t really overdress on an interview day. 9/
Incidentally, you’ll find throughout the day that there will be things like this that you groove on — or not. If you’re Hawaiian shirt casual and the company wants you in a suit, take stock of that. It tells you something about who they are, and how you might fit in — or not. 10/
Fairly early in the interview day (often first thing), you’ll be asked to give a seminar on your research. An hour is typical for PhDs, or 30-40 minutes for a BS/MS. Spend a lot of time preparing for your seminar — it’s the single most important part of your day! 11/
Aim for a PhD seminar to be ~50 minutes long, which means maybe 25 or so slides. Time yourself ahead of time and make sure you’re leaving 10 minutes for questions. If you leave no time for questions, or heaven forbid, run over, folks will be miffed. 12/
Most everyone at your seminar and that you meet with throughout the day has a busy schedule, and they have other meetings to attend or lab work to do. You’re in part showcasing your (in)ability to be succinct. If you run over, you’re disrespecting everyone’s time. 13/
Showcase portable skills in the seminar as you did during the phone interview, but in more depth. Talk about problems solved, obstacles overcome. The how matters more than the what. The exact work you did, cool, cool — but chances are you won’t be doing that in industry. 14/
The audience seeks a sense that you’ll come into the company’s environment and successfully tackle their problems — which are not the same as your grad school problems. They’re also evaluating your comms skills: quickly conveying key points, answering questions on point, etc. 15/
Both because it’s your biggest audience and your first impression on the interview day, the seminar is super-important. In my experience, if you tank the seminar, it’s very hard to recover — you’re fighting uphill. But if you ace the seminar, the job is yours to lose. 16/
The rest of the day will be “office interviews” with more people on the team, either individually or in small groups. These will range from peers to senior folks (your hiring manager and their peers, up to the department head or VP) to folks who might be your direct reports. 17/
You’ll get all manner of questions, because questions are as diverse as the people who ask them. Some folks will drill in deep on the technical details to see if you know your stuff. If e.g. you show a reaction in your seminar, you better be prepared to draw the mechanism! 18/
Other flavors of technical questions can be more speculative. I’ve been on interviews where people threw a molecule up on a whiteboard and asked me how I’d make it, or where I could vary substituents to explore SAR. They want to see how you’d tackle something new. 19/
One company I’ve interviewed at dedicated an interview slot wholly to someone sharing some of the company’s science with me. Again they’re seeing how you engage with new material, and if you can you ask thoughtful/insightful questions to improve your understanding. 20/
There will also be plenty of those targeted selection questions. See here for how to attack those. Think through multiple answers ahead of time. You may get asked the same question more than once by different people — they’re looking to see if your answer stays consistent. 21/
The “soft” questions are most likely to come up when you meet with someone from HR. HR should also give you a rough idea on salary, benefits, etc. Take advantage of this time to mention any personal concerns you may have, e.g. around relocation (if that’s required). 22/
As the company interviews you, you are also interviewing them. Most interviewers will save some time for you to ask them questions about the company, the location, the platform, etc. Be prepared, do your homework! A lack of inquisitiveness on your part comes off poorly. 23/
As you meet with folks, do what I call the “asshole test”. If you meet someone (even one person!) and think, “Man, that person was an asshole!” — think seriously about whether or not you want to work there. Those kinds of fit things tend to magnify with time. 24/
If you gave a good seminar, you’ve built credibility & folks be more inclined to just confirm fit. If you blew the seminar, welp: blood in the water. It’s recoverable, but it’s tough. Good hosts will always remain kind though, even/especially when they know you’re struggling. /25
After the interview imo it’s good form to send some thank-you emails to the interviewers. A little politeness never hurt anyone. And if someone stumped you with a question in the pressure of the moment, it’s a chance to follow up with an answer and show you’re conscientious. 26/
Interview day is a big day. After this day, in pharma it’s usually a job offer or not. Some pharma companies will conduct follow-up/second round interviews, but that’s unusual in my experience, especially for entry level positions. So we’ll leave it there for now. /end
PS - here’s a link to the previous thread in this series about phone interviews, in case you missed it!
PS 2 - pro tip: have a big set of backup/appendix slides behind your seminar slides. Anticipate likely questions and answer them on slides to save yourself a trip to the whiteboard. Especially important on virtual interviews. That level of preparation leaves a good impression.
PS 3 - for next-level preparation, crack out SciFinder and learn the background of the people on your interview schedule. Read their papers, especially stuff they wrote at the company. If you can ask them intelligent questions about their work out of the blue: super impressive.
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Jensen Huang’s comments from JPM24 are now summarized in a Nvidia blog post. He doubles down on exactly the kinds of things that I’ve been cautioning are wildly optimistic. More below. 👇🏽 1/
Usual disclaimer: it’s op-ed time again. My opinions alone, not my employer’s or anyone else’s. 1.5/
Time for another pharmacology tweetorial on another layer of the selectivity problem: drug promiscuity. Both the things we can control, and the things that are out of our hands thanks to good ol’ Mother Nature. 1/
Usual disclaimer: all thoughts and opinions in this post are my own, and don’t necessarily reflect the opinions of my employer. This thread will feature a higher proportion of opinion than normal, but with reasoning supplied. 2/
This is a coda to the last tweetorial on receptor occupancy and selectivity. Have a gander here. 3/
Time for another pharmacology tweetorial (X-torial?), this time on the subject of receptor occupancy and how it relates to selectivity. 1/
Usual disclaimer: all of this thread is my own thoughts and opinions on the subject, and does not necessarily reflect the views of my employer. Your mileage may vary. Some restrictions may apply. 2/
References first. For an excellent primer on pharmacology in general, which also covers the concept of occupancy extensively, you’ll want to check out this book by my old GSK colleague Terry Kenakin. Chapter X is especially relevant. 3/ sciencedirect.com/book/978032399…
Continuing the occasional Friday pharma #EarlyCareer series. Last time we talked about site interviews. This time let’s talk about negotiating job offers. (Next time we’ll deal with the inevitable rejections.) 🧵 1/
Usual disclaimer: everything in this thread is my observations based on 20+ years of personal experience at pharmas big and small, and should not be construed as reflecting the opinions and practices of, nor an endorsement by, my employer. 1.5/
After a site interview, it’s typical for a job offer or “no thanks” to follow within a few weeks. Allow some time here as more than one person is often being interviewed for a position. If you have time pressure (competing offers), the sooner you tell the company, the better. 2/
Since we’re all watching The Last of Us, is it really true that we have nothing (other than bombs) for the coming fungal pandemic? Time to review what we’ve got in the pharmacopeia for fungal infections. Lest we all turn into zombies. 🧵 1/
Broadly, antifungals are woefully under-researched, even among anti-infectives. Fungi are more similar to animals than plants or bacteria. That relative same-ness means finding drugs that target fungi without targeting ourselves is tough. And resistance is ever on the rise. 2/
There are three big main classes of antifungal (or anti-mycotic) agents. Two of those three lean on the fact that fungi make use of ergosterol as the main sterol in their cell membranes rather than the cholesterol typically found in animals. 3/
I’m going to offer some more regular industry #EarlyCareer tips on Fridays. Keeping this focused on chemistry in pharma since that’s what I know about.
Let’s start with applying for the job! 🧵 👇 1/
First off, unlike many other lines of industry work, in pharma chemistry we usually ask for a comprehensive academic-style curriculum vitae (CV) rather than a shorter résumé. Sometimes these terms get used interchangeably in the US, but they’re not the same. 2/
This removes some pressure to compress your professional life into a page or two. A CV typically includes: contact info, work history (most recent first), educational history (most recent first), complete publications & presentations, and possibly other optional sections. 3/