Continuing the Friday pharma industry #EarlyCareer tip series. Last time we talked about phone interviews. This time let’s talk about the next step, a really big one: on-site interviews. 🧵 1/ The Most Interesting Man in the World: I don’t always go o
If your phone interview goes well, the hiring manager will usually invite you for a site interview. Pre-pandemic, that almost always meant traveling to the pharma R&D site for the interview. These days, it may also be done virtually on Zoom or Teams instead. 2/
If you require accommodations for any reason, give the hiring manager or HR person a heads-up before the interview. Most companies are happy to work with you on this if they know. If they won’t, that’s a red flag. Consider then whether or not it’s worth going forward. 3/
If travel is involved, usually you won’t be thrown to the wolves to make your own travel arrangements. An administrative assistant will reach out to help you with transportation, hotel arrangements, etc. (If they don’t, that company’s culture is: you’re on your own!) 4/
Companies usually pick up the tab on travel costs up front, or offer reimbursement. They’ll also offer an allowance for incidentals, such as getting a snack at your hotel or an Uber ride. They don’t want financial barriers to discourage the candidate from interviewing. 5/
For a truly “on site” interview, you may be invited out to dinner the night before the interview. While it’s relaxed and social and a chance to meet more people, remember it’s still part of the interview! They’ll be assessing how easy you are to get along with as a teammate. 6/
Clarify at dinner how you’re arriving at the site the next day: drive yourself, Uber, or is your host picking you up? Turn in early and get a good night’s sleep, you’ll need it! Be on time in the morning. The rest of the thread applies whether you’re in person or virtual. 7/
A site interview is usually a full day for PhDs (maybe a half day for BS/MS folks), and you’ll be tired by the end. (Virtual might be broken up over >1 day though as scheduling allows.) Take bio breaks, coffee breaks, snack breaks — keep your energy up, it’s a long day! 8/
Attire: there are different schools of thought on this. Imo the best thing to do is to ask your hosts what their norms are. Some companies are casual, some formal, so don’t assume. In the absence of this info, lean formal. You can’t really overdress on an interview day. 9/
Incidentally, you’ll find throughout the day that there will be things like this that you groove on — or not. If you’re Hawaiian shirt casual and the company wants you in a suit, take stock of that. It tells you something about who they are, and how you might fit in — or not. 10/
Fairly early in the interview day (often first thing), you’ll be asked to give a seminar on your research. An hour is typical for PhDs, or 30-40 minutes for a BS/MS. Spend a lot of time preparing for your seminar — it’s the single most important part of your day! 11/
Aim for a PhD seminar to be ~50 minutes long, which means maybe 25 or so slides. Time yourself ahead of time and make sure you’re leaving 10 minutes for questions. If you leave no time for questions, or heaven forbid, run over, folks will be miffed. 12/
Most everyone at your seminar and that you meet with throughout the day has a busy schedule, and they have other meetings to attend or lab work to do. You’re in part showcasing your (in)ability to be succinct. If you run over, you’re disrespecting everyone’s time. 13/
Showcase portable skills in the seminar as you did during the phone interview, but in more depth. Talk about problems solved, obstacles overcome. The how matters more than the what. The exact work you did, cool, cool — but chances are you won’t be doing that in industry. 14/
The audience seeks a sense that you’ll come into the company’s environment and successfully tackle their problems — which are not the same as your grad school problems. They’re also evaluating your comms skills: quickly conveying key points, answering questions on point, etc. 15/
Both because it’s your biggest audience and your first impression on the interview day, the seminar is super-important. In my experience, if you tank the seminar, it’s very hard to recover — you’re fighting uphill. But if you ace the seminar, the job is yours to lose. 16/
The rest of the day will be “office interviews” with more people on the team, either individually or in small groups. These will range from peers to senior folks (your hiring manager and their peers, up to the department head or VP) to folks who might be your direct reports. 17/
You’ll get all manner of questions, because questions are as diverse as the people who ask them. Some folks will drill in deep on the technical details to see if you know your stuff. If e.g. you show a reaction in your seminar, you better be prepared to draw the mechanism! 18/
Other flavors of technical questions can be more speculative. I’ve been on interviews where people threw a molecule up on a whiteboard and asked me how I’d make it, or where I could vary substituents to explore SAR. They want to see how you’d tackle something new. 19/
One company I’ve interviewed at dedicated an interview slot wholly to someone sharing some of the company’s science with me. Again they’re seeing how you engage with new material, and if you can you ask thoughtful/insightful questions to improve your understanding. 20/
There will also be plenty of those targeted selection questions. See here for how to attack those. Think through multiple answers ahead of time. You may get asked the same question more than once by different people — they’re looking to see if your answer stays consistent. 21/
The “soft” questions are most likely to come up when you meet with someone from HR. HR should also give you a rough idea on salary, benefits, etc. Take advantage of this time to mention any personal concerns you may have, e.g. around relocation (if that’s required). 22/
As the company interviews you, you are also interviewing them. Most interviewers will save some time for you to ask them questions about the company, the location, the platform, etc. Be prepared, do your homework! A lack of inquisitiveness on your part comes off poorly. 23/
As you meet with folks, do what I call the “asshole test”. If you meet someone (even one person!) and think, “Man, that person was an asshole!” — think seriously about whether or not you want to work there. Those kinds of fit things tend to magnify with time. 24/
If you gave a good seminar, you’ve built credibility & folks be more inclined to just confirm fit. If you blew the seminar, welp: blood in the water. It’s recoverable, but it’s tough. Good hosts will always remain kind though, even/especially when they know you’re struggling. /25
After the interview imo it’s good form to send some thank-you emails to the interviewers. A little politeness never hurt anyone. And if someone stumped you with a question in the pressure of the moment, it’s a chance to follow up with an answer and show you’re conscientious. 26/
Interview day is a big day. After this day, in pharma it’s usually a job offer or not. Some pharma companies will conduct follow-up/second round interviews, but that’s unusual in my experience, especially for entry level positions. So we’ll leave it there for now. /end
PS - here’s a link to the previous thread in this series about phone interviews, in case you missed it!
PS 2 - pro tip: have a big set of backup/appendix slides behind your seminar slides. Anticipate likely questions and answer them on slides to save yourself a trip to the whiteboard. Especially important on virtual interviews. That level of preparation leaves a good impression.
PS 3 - for next-level preparation, crack out SciFinder and learn the background of the people on your interview schedule. Read their papers, especially stuff they wrote at the company. If you can ask them intelligent questions about their work out of the blue: super impressive.

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More from @KRHornberger

Feb 10
Since we’re all watching The Last of Us, is it really true that we have nothing (other than bombs) for the coming fungal pandemic? Time to review what we’ve got in the pharmacopeia for fungal infections. Lest we all turn into zombies. 🧵 1/
Broadly, antifungals are woefully under-researched, even among anti-infectives. Fungi are more similar to animals than plants or bacteria. That relative same-ness means finding drugs that target fungi without targeting ourselves is tough. And resistance is ever on the rise. 2/
There are three big main classes of antifungal (or anti-mycotic) agents. Two of those three lean on the fact that fungi make use of ergosterol as the main sterol in their cell membranes rather than the cholesterol typically found in animals. 3/ Chemical structure of ergosterol, (1R,3aR,7S,9aR,9bS,11aR)-1
Read 20 tweets
Jan 20
I’m going to offer some more regular industry #EarlyCareer tips on Fridays. Keeping this focused on chemistry in pharma since that’s what I know about.

Let’s start with applying for the job! 🧵 👇 1/
First off, unlike many other lines of industry work, in pharma chemistry we usually ask for a comprehensive academic-style curriculum vitae (CV) rather than a shorter résumé. Sometimes these terms get used interchangeably in the US, but they’re not the same. 2/
This removes some pressure to compress your professional life into a page or two. A CV typically includes: contact info, work history (most recent first), educational history (most recent first), complete publications & presentations, and possibly other optional sections. 3/
Read 11 tweets
Dec 31, 2022
Time for a pharmacology tweetorial (of sorts) on one-eyed sheep. It’s an odyssey that began on Idaho ranches in the 1950s and ended over half a century later with the approval of several new cancer drugs for basal cell carcinoma and AML. 1/
Usual disclaimer: all opinions expressed herein are my own, and do not necessarily reflect the opinions of my employer. Nor am I a medical doctor slinging any medical advice. Any errors or omissions are because I’m just a simple chemist. 2/
In the mid-1950s, Idaho ranchers reported that lambs were being born with severe & fatal birth defects, the most visible of which was cyclopia (one eye). This problem had been going on for a long time and was presumed to be genetic. 3/
pubmed.ncbi.nlm.nih.gov/13630801/
Read 31 tweets
Nov 24, 2022
By request, here’s a thread of threads rolling up all of the Drug Discovery Axioms. Bookmark for your convenience. May add a few more in the future.
Read 8 tweets
Mar 15, 2022
Time for another pharmacology tweetorial, this time a second installment on structural alerts. We’ll cover more things about anilines and phenols beyond redox cycling. We’ll also talk about glucuronides generally and a reactive subset (acyl glucuronides) specifically. 1/
For a refresher, please first take a gander at this first thread on structural alerts, where I talked in depth about redox cycling. A lot of these concepts will reappear and be further elaborated upon here. 2/
Let’s start with anilines. Anilines are, as a class, one of the most-remarked-upon structural alert features. Details (and some subtleties) can be found in the review below. 3/
eurekaselect.com/article/63367
Read 28 tweets
Mar 15, 2022
More about “leaving academia”. Even the language of “leaving” is biased and implies that: 1) if there were just more academic jobs, then *of course* everyone would stay; 2) academia is the pinnacle job. None of this is true. 1/7
Most PhDs will pursue non-academic careers. That’s the default state.

Certain folks in academia: (sotto voce) Well, obviously the *best* ones are the ones who stay.

Everyone else: You know it’s just because there’s more jobs available in other employment sectors, right?

2/7
We all have to pass through the halls of the academia before our careers. But that’s education, not a career. What a mind job the academy has done — willfully or passively — by building a false narrative that makes people feel this sense of defeat for going elsewhere. 3/7
Read 9 tweets

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