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Edward Nirenberg 🇺🇦 Profile picture
@ENirenberg
Feb 25, 2023 • 6 tweets • 2 min read • Read on X
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Also you can tell me what else you’d like me to write about on my blog here:

ngl.link/deplatformdise…

Or you can ask me whatever you want too. That seems like a fun way to deal with insomnia
Yes. They’re being actively worked on all the time. One thing that would really help though is an orally bioavailable form of remdesivir. Also molnupiravir should go away.
Pondering the meaning of life for a few hours, then I’ll probably eat something when I accept that there are no good answers to the question bc blood sugar
Thank you, Internet stranger. You are probably great too
The souls of lesser men. Also eggs. It’s not breakfast without eggs.
I mean at this point it’s probably very hard to improve upon VE for severe outcomes considered in a vacuum for any vaccine because they’re so good at it but this hypothetical vaccine likely wouldn’t be approved. I wouldn’t take it- that’s a ~10-30 fold increase in GBS risk.

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More from @ENirenberg

Edward Nirenberg 🇺🇦 Profile picture
Oct 9, 2024
I didn't think I needed to say anything about this paper but I am frankly baffled by how skewed the explanations of its findings have been:


tl;dr- nothing in this study suggests Novavax is better than mRNA

A brief thread 🧵journalofinfection.com/article/S0163-…
The idea is simple enough: 155 adults aged 50-70 who received 2 priming doses of Oxford/AZ's COVID-19 vaccine (adenovirus vector) and a licensed booster 3 months before enrollment were randomized to receive a dose of Pfizer, Moderna, or Novavax's vaccines. Image
Image
People seem to be taking away from this study that Novavax's vaccine somehow gave an immune response that was better than either mRNA vaccine, which is... an odd take. The paper emphasizes that the antibody titer with Novavax was more sustained. This is true, however...
Read 15 tweets
Edward Nirenberg 🇺🇦 Profile picture
Oct 8, 2024
New paper in Cell describes an antibody from Vir that seems to have potent activity against a number of coronaviruses, some of which do not even use ACE2:


A thread summarizing the findings
1/10 sciencedirect.com/science/articl…Graphical abstract from the paper summarizing the antibody Vir-7229. The antibody shows high potency in protecting hamsters from challenge with SARS-CoV-2, exquisite resistance to mutation, and is much more difficult to escape via serial passage of pseudoviruses than comparable antibodies.
First though I want to spend a minute talking about where this antibody came from, because this aspect of things tends to be underappreciated. Before there was Vir-7229, there was S2V29, a candidate antibody that covered all SARS-like coronaviruses:

2/10 nature.com/articles/s4158…Image
S2V29 came from a participant who had been vaccinated against and infected with SARS-CoV-2. From there, S2V29 underwent affinity maturation using SARS-CoV-1, SARS-CoV-2, and BQ.1.1 variant RBDs via yeast display. These were then screened and revealed an antibody that had...
3/10 Image
Read 10 tweets
Edward Nirenberg 🇺🇦 Profile picture
Sep 27, 2024
I see some discussion of this paper going around:


It was preprinted a while ago but since that time I have had an opportunity to talk to some plasma cells researchers and it is apparent that there is a lot of important nuance being missed 🧵nature.com/articles/s4159…
Background: antibodies against the spike protein are protective against infection by SARS-CoV-2. Antibodies are made by antibody-secreting cells (ASCs) which come from B cells and vary widely in their lifespan. The goal of vaccination is generally to elicit durable antibodies.
Long-lived plasma cells (LLPCs) are ASCs that can live for many years (potentially your lifetime). They are canonically found within the bone marrow, but mucosal LLPCs have also been described. The problem: there is no simple way to define look at a cell and say it's an LLPC.
Read 17 tweets
Edward Nirenberg 🇺🇦 Profile picture
Jul 30, 2024
Seeing people talk about this case report recently... Some are framing this as evidence that SARS-CoV-2 *routinely* causes devastating neurological disease, which isn't true and is ultimately not an honest interpretation of the data therein. 🧵

ijidonline.com/article/S1201-…
IMO it is very hard to conclude anything about the general behavior of SARS-CoV-2 with regard to the brain from this case report, especially as it applies to today. For one, this case report describes an infection that happened in 2020- but this a relatively minor detail... Image
compared with this part: the patient in question had HIV (was not aware of it), had a massive viral load, and a CD4 T cell count that is known to produce every AIDS-defining condition seen in PLWHIV. One of these conditions is progressive multifocal leukoencephalopathy (PML). Image
Read 15 tweets
Edward Nirenberg 🇺🇦 Profile picture
Jul 11, 2024
Aaron Siri is misrepresenting a perspective piece in NEJM authored by Daniel A. Salmon, Walter A. Orenstein, Stanley A. Plotkin, and Robert T. Chen concerning vaccine safety studies. You can read the perspective via these screenshots (it's paywalled). Some comments from me 🧵:


Image
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The gist of the perspective is that vaccine safety studies take a lot of time. The US currently has a means to compensate those harmed by vaccines via the NVICP, and the budget for the NVICP comes from an excise tax on vaccines, and it has a large surplus at the moment.
Therefore, it would make sense to divert at least some of that funding to research harms from vaccines that can be used to better understand them. A major concern here is the lack of efficient funding delays this work. It does not at any point argue that vaccines are unsafe.
Read 23 tweets
Edward Nirenberg 🇺🇦 Profile picture
Jun 30, 2024
One thing on my mind more in recent times is the way that we've managed to make health, and in particular public health, feel normative- and in some ways that's a double-edged sword.

Undeniably, it's far more positive than it is negative.
If someone drinks milk and gets paralyzed from Guillain-Barre syndrome today, that is a shocking event.

If someone takes a medication and develops lead poisoning from it being tainted, that is a shocking event.
If someone develops radiation poisoning from their drinking water, that is a shocking event.

If there's a cholera outbreak in a metropolitan area, that is a shocking event.

Today, all of these things lie far outside the bounds of what is ordinary in the US.
Read 9 tweets

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