Also you can tell me what else you’d like me to write about on my blog here:

ngl.link/deplatformdise…

Or you can ask me whatever you want too. That seems like a fun way to deal with insomnia
Yes. They’re being actively worked on all the time. One thing that would really help though is an orally bioavailable form of remdesivir. Also molnupiravir should go away.
Pondering the meaning of life for a few hours, then I’ll probably eat something when I accept that there are no good answers to the question bc blood sugar
Thank you, Internet stranger. You are probably great too
The souls of lesser men. Also eggs. It’s not breakfast without eggs.
I mean at this point it’s probably very hard to improve upon VE for severe outcomes considered in a vacuum for any vaccine because they’re so good at it but this hypothetical vaccine likely wouldn’t be approved. I wouldn’t take it- that’s a ~10-30 fold increase in GBS risk.

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More from @ENirenberg

Feb 17
it’s a good night for some chaos AMA

ngl.link/deplatformdise…
Yes

(But actually whom for object, who for subject)
02:41 AM per my watch
Read 47 tweets
Feb 12
This is a tough read. Undeniably the fact that WHO was so slow to acknowledge airborne spread was one of the biggest missteps of the pandemic. At the same time, my sense from reading WHO's responses is that the reluctance here was based...

academic.oup.com/cid/advance-ar…
at least in large part on concern about the availability of resources across member states to institute relevant airborne precautions at the necessary scale. At the same time, I think the piece highlights one of the more insidious aspects of the public communications ...
here in that "airborne" has a specific meaning in a medical context (i.e. spreading over large distances by aerosols) which is different from what it means to the layperson (i.e. it is in the air and can be inhaled and make you sick) and also implies that airborne spread...
Read 4 tweets
Jan 29
I have now read the claim that because SARS-CoV-2 can infect the testes and integration of its genome has been demonstrated, it will become endogenized.

This is like really bad virology fan fiction.
SARS-CoV-2 doesn’t reverse transcribe into the genome or integrate into it. Findings suggesting otherwise involve massively overexpressing LINE1 at levels far past what occurs in (non-cancerous, non-embryonic) human cells. This has been examined, including w/ patient samples:
Read 5 tweets
Jan 28
This is a really nice summary:

theconversation.com/does-covid-rea…

I have some quibbles about the bit on “immunity debt” but overall this is well referenced and accurate.
Re the “immunity debt” thing- I think the name is bad as it connotes that you need to be sick to be healthy which simply put is nonsense; however, many respiratory viruses, especially RSV, do not generate durable or complete immunity. Absent a vaccine, the only way…
To maintain high levels of immunity in the population is by boosting with infection. This points to an urgent need for a vaccine for, at least, the most pathogenic of these viruses (especially RSV). It also underscores that we should be mindful of “divorce effects…”
Read 4 tweets
Jan 26
Live tweeting the VRBPAC meeting in this thread. See here for materials and meeting live:
fda.gov/advisory-commi…

Also I have an errand to run during the break/public comment period so I can't cover that.
As a reminder, here is the voting question for today's meeting:
Dr. Arnold Monto will not be able to chair today's meeting due to unforeseen circumstances; Dr. Stanley Perlman will chair it instead:
medicine.uiowa.edu/microbiology/p…
Read 279 tweets
Jan 26
This is an amazingly thorough assessment of the immunity elicited by vaccination and hybrid immunity. Some highlights🧵

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination biorxiv.org/content/10.110…
✅ adenovirus vectors induced greater T cell responses than mRNA in hybrid immune and uninfected; residency was more durable in cases of hybrid immunity
✅ B cells rare in the lungs in general but more frequent w/ hybrid immunity
✅ Spike T cells enriched in airways vs. blood
✅ Different antigen specificity of T cells based on blood or respiratory tract
✅ IgG in airways more durable than IgA in airways. Implications of this are not entirely clear.

I can see multiple interpretations of the findings but I think this points to the need for...
Read 4 tweets

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