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Mar 10, 2023 13 tweets 3 min read Read on X
The Norwegian Healthcare Investigation Board, (NHIB/UKOM) has deemed puberty blockers, cross-sex-hormones & surgery for children & young people experimental, determining that the current “gender-affirmative” guidelines are not evidence-based and must be revised. /1
The UKOM report asserts that future guidelines must rely on a systematic review of evidence rather than cherry-picking studies, and that all hormonal and surgical interventions must be restricted to research settings to ensure clear protocols, safeguarding & adequate follow-up./2
The existing Norwegian treatment guidelines for gender-dysphoric youth, based on a 2015 report ”The Right to the Right Sex,” closely mirror WPATH SOC7 “gender-affirming” model. Medical gender affirmation is widely available to youth, with no psychological assessments required. /3
Under the current Norwegian guidelines, youth may receive puberty blockers at tanner stage 2, cross-sex-hormones at 16, and surgeries at 18. The report noted that these widely available interventions are irreversible, carry many risks, and rest on insufficient evidence. /4
The report criticized Norway’s current "gender-affirmative" guidelines as inadequate, noting a lack of specificity regarding assessment & determination of medical necessity of risky and irreversible interventions provided to youth whose identities are still forming. /5
The Norwegian Healthcare Investigation Board noted several worrying trends: the rapid rise of gender dysphoria in adolescents (esp. females), the high burden of mental illness (75%) & a high prevalence of neurocognitive conditions (ADHD/autism, Tourette) in the affected youth. /6
The recommendations by the Norwegian Healthcare Investigation Board (NHIB/UKOM) align Norway with the changes among the growing number of European countries (Sweden, Finland, England) which aim to safeguard youth from harm by sharply restricting youth gender transitions. /7
However, unlike Sweden, Finland and England, Norway explicitly calls out the group of young adults whose development is still ongoing and who are at risk for erroneously undertaking gender transitions. The report notes that the age of consent for sterilization in Norway is 25./8
NHIB/UKOM notes that the right to medical care does not include the right to experimental treatments. As an experimental intervention, gender transitions will be subject to heightened scrutiny around informed consent, eligibility criteria, and outcomes evaluation./9
Norway's proposed model appears to resemble the model of care outlined in the Cass review. Gender dysphoric youth will receive care for their distress in local primary care settings with multidisciplinary support. Youth gender transitions will be an exception, not the rule. /10
The Board also comments on the highly polarized & unbalanced nature of the discussions surrounding care for gender-dysphoric youth, which stifles scientific debate. The Board calls on all parties to treat each other with professionalism, empathy and respect. /11
SEGM will be analyzing the report in more detail. Currently, our assessment is that the UKOM report is akin to UK's Cass Review in that it makes recommendations for restructuring youth gender services. How Norway's NHS will implement these recommendations remains to be seen. /12
The largest Norwegian daily newspaper, Aftenposten, interviewed the UKOM project leader, Stine Marit Moen. The links to the interview, the executive summary, and the full report are are provided below. /13
aftenposten.no/norge/i/jlwl19…
ukom.no/rapporter/pasi…
https://t.co/3gWmdKZTHQ

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More from @segm_ebm

Jun 16
🧵Last year, a paper by the @TrevorProject authors claimed that "anti-transgender" laws cause a 7–72% increase in youth suicide attempts—a figure since cited in media, policy, and litigation. A new critique in @NatureHumBehav shows the claim doesn't add up. New SEGM spotlight⬇️/1 Image
The @TrevorProject paper's key finding of "up to 72% increase in suicide attempts" caused by legislative restrictions came from a single state—Idaho—with n≈60, and with no relevant laws in force at the time, as our latest Spotlight explains. ⬇️/2

segm.org/Trevor-project…
The critique of the Trevor Project's paper by Cohn et al. (Cohn is affiliated w/@segm_ebm) identified a series of methodological problems that put the entire premise of the paper in serious doubt. There is no credible evidence that state restrictions caused youth suicidality. /3 Image
Read 10 tweets
May 28
🚨A widely cited Trevor Project paper from 2 yrs ago concluded that state restrictions on youth gender transition increase youth suicide risk. But a new peer-reviewed reanalysis shows the signal came from a single state, Idaho—which had no such restrictions during the study. /1 Image
Two years ago, a paper in Nature Human Behaviour claimed that “anti-trans” laws, including restrictions on pediatric gender transition, increased suicidality among gender-dysphoric youth. Today, a commentary in the same journal challenges that claim. /2
nature.com/articles/s4156…
The peer-reviewed commentary by Cohn et al. identifies major limitations in the original Nature Human Behaviour study. Its headline claim — that “anti-trans” laws caused a 72% rise in suicidality — relied heavily on a few hundred respondents from Idaho, where no laws restricting pediatric transition were in effect during the study period.
The only two potentially relevant laws in Idaho around the study time period were HB 500, which restricted male participation in the female category in school sports, and HB 509, which concerned the recording of sex on birth certificates.
But one of these laws was blocked more than a year before the signal of increased suicidality appeared in the data—and the other never went into effect at all.
/3
Read 5 tweets
Apr 2
After Utah passed a moratorium on medical youth gender transitions in 2023, activist groups lobbied for an evidence review to prove this practice is safe and effective. The result was the "Utah Review," which produced the desired answer by scrapping methodological standards. /1 Image
SEGM's recent analysis shows that the Utah Review is not objective nor independent. The Review was overseen by advisors with serious conflicts of interest, including ties to Utah’s leading children’s gender clinic. /2
segm.org/utah-evidence-…
The Utah Review is also, to put it bluntly, not a systematic review of evidence, despite claims to the contrary. It failed to synthesize the evidence and assess it for quality/certainty—a crucial step in any systematic review. /3
Read 14 tweets
Mar 10
📢NHS England just published 10 new systematic evidence reviews on PB and CSH for binary and “non-binary” youth. Because of the weak evidence, the NHS paused new cross-sex hormones prescriptions and is conducting a 90-day consultation to review evidence for a potential permanent ban. /1Image
Of the 10 new evidence reviews, 8 cover masculinizing & feminizing hormones, with and without GnRH analogues, for “binary” and “partial”/NB transition. Two additional reviews examine GnRH monotherapy specifically for male and female youth who ID as NB. /2

england.nhs.uk/publication/co…
The new reviews add to a list of now over 20 systematic reviews, all of which come to the conclusion: evidence is insufficient to support the practice of pediatric medical gender transition.

Puberty blockers are already permanently banned in the UK in both public (NHS) and private settings. Cross-sex hormones for minors were still technically allowed but with significant restrictions implemented post-Cass as we described in our spotlight.

The March NHS England announcement indicates a permanent ban on puberty blocker in the NHS settings is being considered. Whether or not it will be extended to private settings is as yet unknown. The consultation period for the proposed NHS ban ends on June 7, 2026. /3

segm.org/England-UK-Pub…
Read 13 tweets
Feb 5
🚨 In a watershed moment, the American Society of Plastic Surgeons has put an end to youth gender surgeries. But a far bigger story is what this implies for the rest of "gender-affirming care," from social transition to puberty blockers & hormones—as our new analysis explains. /1 Image
About 1,000+ mastectomies for gender-dysphoric minors are performed each year in the U.S, most done by plastic surgeons. The ASPS statement suggests this practice will be upended. But the analysis that ASPS offers for the rest of the transition pathway signals far more profound changes are likely to come.
The ASPS asserts that all steps in youth transition—from social transition and puberty blockers to cross-sex hormones and surgery— are interconnected; that all share similarly problematic risk–benefit profiles; and the risk compounds with each subsequent step.
This puts other medical associations on notice. At the very least, they have to review and adjust their own positions—or justify why they continue to stand by a practice that is not evidence-based and is profoundly ethically challenged. /2

segm.org/ASPS-position-…
It is no accident that plastic surgeons are the first professional association to take a strong stance against a key intervention in the "gender-affirming" care pathway for youth.  

1. Unlike endocrine interventions, where physical changes unfold gradually and the extent of irreversibility may only become clear over time, surgery is universally understood as irreversible from the outset. When the risk–benefit ratio is unfavorable, surgeons have no gray area to retreat into—they must decide whether to operate.
2. Because surgery is typically the final step in the transition pathway, surgeons inherit the cumulative risks and uncertainties of the upstream interventions. That vantage point likely contributed to why the professional association representing plastic surgeons was among the first to recognize the full scope of the problem.
3. Most importantly, plastic surgery is unusual among medical specialties in routinely providing both elective cosmetic procedures and medically necessary care. This positions plastic surgeons to distinguish between interventions that are medically indicated and those that may primarily offer patient satisfaction without improving health outcomes. /3
Read 8 tweets
Dec 4, 2025
A must-listen/read interview between @DouthatNYT and Chase Strangio in the NYT today. While the tone toward critics of youth gender transition is more collegial, Strangio still misstates the evidence, claiming hormones are proven to significantly reduce distress & suicidality. /1 Image
When pressed on psychotherapy for gender dysphoria, Strangio concedes it should be available, and does NOT level the charge of "conversion therapy." Still, Strangio conflates therapy with changing identity. Letting go of one's drive to medicalize has no such requirement. /2 Image
Strangio laments that states imposed restrictions on youth transitions without a chance for more measured steps. But professionals (incl. @segm_ebm, @JuliaMasonMD1 ) have pleaded for years with @AmerAcadPeds and other medical organizations to course-correct, only to be ignored./3 Image
Read 5 tweets

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