What happens to Plasymacytoid Dendritic Cells (pDCs) when you are infected with COVID19/Omicron?
What are pDCs and what do they do?
Can a cash reward help those who have been affected?
- observations of someone with ‘too much time on their hands’….
What are pDCs and what do they do?
Can a cash reward help those who have been affected?
- observations of someone with ‘too much time on their hands’….
“The presence of viral RNA in the bone marrow… indicates that both might represent equally advantageous environments for the virus to survive and replicate.”
mdpi.com/2075-4418/12/2…
mdpi.com/2075-4418/12/2…
“An important question is if it may also damage hematopoietic stem progenitor cells?”
nature.com/articles/s4137…
nature.com/articles/s4137…
“.…the recovery of DC cell numbers and function after COVID-19 is unknown”
nature.com/articles/s4142…
nature.com/articles/s4142…
So what if they are gone… Is there a clinical significance associated with chronic pDC deficiencies?
https://twitter.com/totalcytopath/status/1624967067949473793?s=46&t=X0x9cZ7tInCUtUq9zSUoLw
There are many clinically significant implications of pDC deficiency. Here’s a few…
“pDCs detect viral infections through the recognition of viral nucleic acids and are important mediators of antiviral immunity.”
sciencedirect.com/science/articl…
“pDCs detect viral infections through the recognition of viral nucleic acids and are important mediators of antiviral immunity.”
sciencedirect.com/science/articl…
“Activated pDCs can directly kill breast tumor cells in a TRAIL and Granzyme B-dependent fashion. Furthermore, pDCs activate NK cells and CD8+ T cells, and ultimately inhibit breast tumor growth.”
frontiersin.org/articles/10.33…
frontiersin.org/articles/10.33…
“In addition, plasmacytoid dendritic cells can limit immunopathology, and promote peripheral tolerance to prevent allergic sensitisation to harmless antigens, possibly through the induction of regulatory T-cells.” erj.ersjournals.com/content/43/1/2…
“…reduction in the number of pDCs & the IFN-α levels in children with asthma… the mechanisms whereby infants exhibit increased susceptibility to the development of allergic immune responses in the lungs.”ncbi.nlm.nih.gov/pmc/articles/P…
“Clinical studies have identified that reduced numbers of circulating plasmacytoid dendritic cells (pDCs) act as a predictor of cardiovascular events in coronary artery disease..” ahajournals.org/doi/10.1161/AT…
“..our data point to an unexpected protective role of pDC in atherosclerosis, which is in contrast to the prevailing notion that pDC might promote atherosclerosis.”
ahajournals.org/doi/10.1161/CI…
ahajournals.org/doi/10.1161/CI…
“..in addition to their role in antiviral immunity, recent studies suggest that pDCs also play an important role in antifungal immunity.”
frontiersin.org/articles/10.33…
frontiersin.org/articles/10.33…
“These results suggest a protective role of pDCs in acute liver inflammation.”jci.org/articles/view/…
“Loss of pDCs Abolishes Innate Control of Coronavirus Infection.”
“Thus, pDC-deficient animals show defective induction of an antiviral CD4+ T-cell response, whereas the few developing CD4+ T cells become functionally exhausted”
pnas.org/doi/10.1073/pn…
“Thus, pDC-deficient animals show defective induction of an antiviral CD4+ T-cell response, whereas the few developing CD4+ T cells become functionally exhausted”
pnas.org/doi/10.1073/pn…
Furthermore, a higher pDC frequency was significantly correlated with… overall survival of patients with colon cancer. jitc.bmj.com/content/9/3/e0…
“This is the first study demonstrating the direct effect of plasmacytoid dendritic cells in reducing vascular endothelial cell proliferation and differentiation in vitro. pDCs may thus serve as a new cell-based therapy for the treatment of angiogenesis” iovs.arvojournals.org/article.aspx?a…
“Loss of circulating pDCs correlates with a high HIV viral load and the occurrence of opportunistic infections and Kaposi sarcoma.”nature.com/articles/ni1141
“Moreover, pDCs could also respond to certain non-viral pathogens such as bacteria (e.g. Chlamydia pneumoniae) and apicomplexan parasites” onlinelibrary.wiley.com/doi/full/10.10…
AJ raised the alarm that the pDCs were gone irreversibly:
https://twitter.com/fitterhappierAJ/status/1605185074101907456
The missing Plasmacytoid Dendritic Cells are the smoking gun.
https://twitter.com/oliver_phil/status/1621872124154753025
Attempts to divert have been clumsy and irrational:
https://twitter.com/oliver_phil/status/1625522644799082497
We could easily test those affected to confirm this in severe/mild/recovered/long covid:
https://twitter.com/oliver_phil/status/1632291229710028802
My reward is yet to be claimed (16k+ views). Billionaires are #DavosSafe. Children in schools around the world are not #DavosSafe. We are now in a race against time for the development of therapies... and justice. Take care ✌️
https://twitter.com/oliver_phil/status/1624429899418341383
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