Today is #LongCovidAwarenessDay
LongCovid is a condition comprising often severe symptoms that can affect many different organs. It occurs following infection with SARS-CoV-2. Symptoms include cardiovascular, respiratory, neurological as summarised by @EricTopol and colleagues
Its REALLY common. Estimates vary - it occurs in at least 10% of Covid 19 infections and around 65 million individuals worldwide are estimated to have Long Covid.
It can occur irrespective of severity of the initial disease and any person of any age can be affected. The highest percentage of diagnoses are between the ages of 36 and 50 years but even children are affected. longcovidkids.org
Long COVID is persistent- with data emerging that in those with long COVID, the rate in which symptoms affected daily life decreased from 45% → 25% over 7 months. That’s a LONG time for ANYONE to suffer.
We don’t yet know WHY it is happening but there is clear underlying biology and immunology. For example some individuals have latent viral reservoirs, some have immune abnormalities causing autoimmunity and some have clotting abnormalities. nature.com/articles/s4157…
This is still with us, although vaccination and prior infection have created some immunity-there is still a risk. e.g. In UK, risk of long COVID dropped after 2nd infections compared to 1st (4% → 2.4%). Risk is clearly NOT zero.
COVID-19 infection is NOT a trivial thing and it can still cause severe disease in some individuals and the risk of LongCovid MUST be acknowledged. We are learning more about this condition but we need to be able to better diagnose, treat it and support those with this condition.
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A brief 🧵on the term ‘immunity’ - this is perhaps misunderstood by many and exploited by others.
Immunity refers to the development of memory immune cells -T and B cells that have encountered a pathogen (virus,bacteria,funghi,parasite) and have gone through the necessary programming to be able to react to that pathogen should they meet it again
Memory cells are extremely long lived. For example survivors of the 1918 flu pandemic still had evidence of memory B cells over 80 years after they had been infected