Future sepsis therapies session💉🦠
Disease tolerance by Christopher Seymour @seymoc
🔸Difficulties in measurement
🔸May become a new focus in future clinical trials
@ISICEM #isicem23
Disease tolerance by Christopher Seymour @seymoc
🔸Difficulties in measurement
🔸May become a new focus in future clinical trials
@ISICEM #isicem23
Immune stimulation by Anthony Gordon @agordonICU
🔸Sepsis occurs as a result of dysregulated immune reactions.
🤔What happens when stimulating the immune system in patients with immune suppression?
A large RCT on GM-CSF is ongoing.
europepmc.org/grantfinder/gr…
@ISICEM #isicem23
🔸Sepsis occurs as a result of dysregulated immune reactions.
🤔What happens when stimulating the immune system in patients with immune suppression?
A large RCT on GM-CSF is ongoing.
europepmc.org/grantfinder/gr…
@ISICEM #isicem23
Coagulation therapies in sepsis🩸
Essential tasks before planning and performing future clinical trials
-risk stratification when assessing eligibility (= personalization)😷
-identification of optimal treatment timing/duration⏰
@ISICEM #isicem23
Essential tasks before planning and performing future clinical trials
-risk stratification when assessing eligibility (= personalization)😷
-identification of optimal treatment timing/duration⏰
@ISICEM #isicem23
Personalized therapies in sepsis by @Lennie333
🔸We have changed how we see sepsis: moving from “syndrome” to “personalization”
🔸Clustering patients to small subgroups using POC techniques: “treatable trait”
🔸Umbrella trials/Basket trials/Platform trials
@ISICEM #isicem23
🔸We have changed how we see sepsis: moving from “syndrome” to “personalization”
🔸Clustering patients to small subgroups using POC techniques: “treatable trait”
🔸Umbrella trials/Basket trials/Platform trials
@ISICEM #isicem23
A question from @BellomoRinaldo was relevant given that platform trials are and will be more and more common in ICU settings.
“How can the complicated findings of platform trials be correctly conveyed to clinicians?”
There might be no clear answer now...
@ISICEM #isicem23
“How can the complicated findings of platform trials be correctly conveyed to clinicians?”
There might be no clear answer now...
@ISICEM #isicem23
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