Thread by @YukiKotani5

Day 3 of #ISICEM23 begins with
Sepsis: the first steps

There are many things to do in the first few hours of sepsis care, e.g.,
🦠Sampling for pathogens
💉Antibiotics
📝Severity assessment
🫀Resuscitation

This session will address a whole picture of the initial TO DOs!
@ISICEM

Sepsis prediction is challenging

🔸Heterogeneity
🔸High AUROC ≠ High utility in clinical context
🔸Poor generalizability to different settings (units, department)
🔸Necessity of prediction??

@ISICEM #ISICEM23

Septic shock prediction @KhannaAshishCCM

🔸Hypotension increases the risk of death
🔸Patients at risk of shock development are the target population (proactive🟡 rather than reactive🔴)
🔸But continuous monitoring is lacking because they are out of ICU

@ISICEM #ISICEM23

Early risk prediction

🔸qSOFA is of limited performance
🔸Need for better prediction models (biomarkers)
🔸Several recent models may be applicable to sepsis and COVID-19
🔸Prediction model can be used to identify patients who will benefit from treatments

@ISICEM #ISICEM23