Thread by @PTarantinoMD

Reading good review articles can shape ideas, help connecting the dots and understanding what’s coming ahead in science.

Here’s 10 review articles that helped me shape my views on breast oncology and drug development:

1. The basics, first. What is breast cancer? How do we classify it, how do we treat it? In this article, Ada Waks et al. provide a comprehensive view of the clinical management of breast cancer, recapitulating decades of advancements in the field.
jamanetwork.com/journals/jama/…

2. Now, a deeper dive into the subtypes. Despite being intensively studied, ER+ breast cancer remains elusive in many aspects. In this article, @DrHBurstein reviews the biology and paradigms behind the treatment of the most common subtype of breast cancer.
nejm.org/doi/full/10.10…

3. ER+ may be the most common, but triple negative surely is the most hard-to treat subtype of breast cancer. Here, @BianchiniGP et al. review the intricacies of a heterogenous disease, that we still define for what is it not, rather than for what it is.
nature.com/articles/s4157…

4. Recognizing the relevance of HER2 has had a major impact in oncology in the last decades. In this Review, S.Swain et al. take us across the impressive successes achieved in HER2 targeting to date, and the next steps expected in this glorious path.
nature.com/articles/s4157…

5. As very few other drugs classes, ADCs are revolutionizing the treatment of cancer. Here, @JoshDragoMD et al. dive deep into the mechanisms of action and resistance of these complex drugs, whose potential is still far from being fully explored.
nature.com/articles/s4157…

6. Unleashing the potential of ADCs may require challenging established dogmas on how these compounds work. In this thought-provoking piece, @Raffaele_1985 et al. highlight important knowledge gaps and open questions on the treatment of cancer with ADCs.
cell.com/cancer-cell/pd…

7. Among the dogmas in need of reassessment is also the role of anthracyclines for treating breast cancer. In this article, Sara Hurvitz et al. review the multiple reasons why the use of anthracyclines should be reassessed, and in certain cases avoided.
nature.com/articles/s4152…

8. Liquid biopsy promises to reshape the way we manage breast cancer. Yet, many challenges remain to be tackled in the field. In this article, @MIgnatiadis et al. draw a roadmap for the utilization of liquid biopsies to better understand and treat tumors.
nature.com/articles/s4157…

9. Beyond novel biomarkers, translating our knowledge on the molecular underpinnings of cancer into clinical benefits will require novel frameworks. Here, J. Mateo et al. highlight key opportunities and challenges in the delivery of precision oncology.
nature.com/articles/s4159…

10. Lastly, a provocative, forward-looking piece that I found motivating: “curing metastatic breast cancer”, by @GeorgeSledge51. An ambitious, complex goal, which nonetheless needs to remain on our radar, and receive dedicated attention and research.
ascopubs.org/doi/10.1200/JO…

This is far from being a comprehensive list. Still, I hope that some will find it useful, and derive from these articles the inspiration and motivation I got from them along the years.

Please feel free to suggest additional reviews, and share the list if you found it useful!