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Take the latest #NeurologyRF quiz: A 43-yr-old woman presented with altered mental status and hypertension. She had a 3-day history of oliguria. Blood testing detected microangiopathic hemolytic anemia, thrombocytopenia, and severe kidney injury.
Pictured: Admission brain MRI
Pictured: Admission brain MRI
Shiga-like toxin and ADAMTS13 autoantibodies were absent. Normal ADAMTS13 activity and renal biopsy were consistent with atypical hemolytic uremic syndrome with neurological involvement.
What is the first-line treatment choice for the suspected condition?
The answer is: A. Anti-C5 monoclonal Ab
Pictured: After 3 months of treatment with eculizumab and twice-weekly hemodialysis.
Widespread leukoencephalopathy could be associated with atypical hemolytic uremic syndrome and partially reversed after treatment with eculizumab and hemodialysis.
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