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Apr 19 23 tweets 205 min read Twitter logo Read on Twitter
@TumorBoardTues @JenniferLitton 1/18 #TumorBoardTuesday #BreastCancer #OncTwitter

32 yo 👩🏽
4 months post-partum
🚫comorbidities
FHx paternal uncle with #PanCan
🔬Bx: L breast mass - IDC, G3, ER 50%, PR 30%, HER2 0, Ki67 30%
Clinically node+; FNA confirms LN involvement
🚫 e/o metastatic dz

🤔Do all EXCEPT?
@TumorBoardTues @JenniferLitton 2/18 #TumorBoardTuesday #BCSM @JenniferLitton

🧬 testing returns with BRCA2 path variant
✂️ L mastectomy and ALND
Right risk ⬇️ mastectomy
Found to have 8+/15 LNs
Undergoes adjuvant AC/T

🤔After referring to ☢️ XRT, you discuss which of these treatments?

ET= AI+OS vs Tamoxifen
@TumorBoardTues @JenniferLitton @JasmineSukumar @Dr_RShatsky @awolff @jane_meisel @sardesai_sagar @andMORand @MassimoDiMaio75 @MLambouras @melindatelli @IBCradiation @TJH0828 @naborala @MuozMateu @FadwaARahman @emrekocamd @spinmaplered @LeandroJonatad1 @crisonco @adrianakahnmd @MamMa_mimumemo @LauBuisseret 3/18 #TumorBoardTuesday @MPishvaian @JohnEbbenMDPhD

👩🏻‍🏫 Mini tweetorial 1 👩🏼‍🏫

🧬Genetic testing

‼️EVERYONE w/ MBC or ⬆️risk EBC should have genetic testing‼️
Per @NCCN, pts with BC and:
🧬Age ≤ 50 y
🧬MBC
🧬⬆️risk HER2- EBC
🧬TNBC
🧬Male BC
🧬FMH, etc
📚nccn.org/professionals/… Image
@TumorBoardTues @JenniferLitton @JasmineSukumar @Dr_RShatsky @awolff @jane_meisel @sardesai_sagar @andMORand @MassimoDiMaio75 @MLambouras @melindatelli @IBCradiation @TJH0828 @naborala @MuozMateu @FadwaARahman @emrekocamd @spinmaplered @LeandroJonatad1 @crisonco @adrianakahnmd @MamMa_mimumemo @LauBuisseret @MPishvaian @JohnEbbenMDPhD @NCCN @ASBrS 5/18 #TumorBoardTuesday
👩🏻‍🏫 Mini tweetorial 3👩🏼‍🏫

PARPi in pre-tx MBC with gBRCA1/2 mut
🔸OlympiAD: PFS 7.0 mo olaparib vs 4.2 mo chemo (HR 0.58)
🔸EMBRACA: PFS 8.6 mo talazoparib vs 5.6 mo chemo (HR 0.54)
⬆️Safety/QOL than chemo
📚nejm.org/doi/full/10.10…
📚nejm.org/doi/full/10.10… ImageImage
@TumorBoardTues @JenniferLitton @JasmineSukumar @Dr_RShatsky @awolff @jane_meisel @sardesai_sagar @andMORand @MassimoDiMaio75 @MLambouras @melindatelli @IBCradiation @TJH0828 @naborala @MuozMateu @FadwaARahman @emrekocamd @spinmaplered @LeandroJonatad1 @crisonco @adrianakahnmd @MamMa_mimumemo @LauBuisseret @MPishvaian @JohnEbbenMDPhD @NCCN @ASBrS 6/18 #TumorBoardTuesday
👩🏻‍🏫 Mini tweetorial 4👩🏼‍🏫

✨OlympiA✨
🔸Ph III RCT, HER2-neg early BC with gBRCAm
🔸After standard NACT/adj chemo and local therapy
🔸Adjuvant olaparib x1 year vs placebo
🔸If HR+ s/p adjuvant chemo, must have ≥4 +LNs
📚@judygarber5 nejm.org/doi/full/10.10…

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