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Jithu kurian🇮🇳 Profile picture
@Jithukurian6
Apr 28 • 6 tweets • 3 min read Twitter logo Read on Twitter
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What i learnt today at #ApexPathshala second day of amazing talks and interactions

Immunosuppressive protocol by prof Dr S k Agarwal and Prof Dr. Jeremy chapman

🔥 the ⏰ timeline of drug development ImageImage
🔥 few ♥️ cardinal points of immunosuppression Image
🔥 risk stratification of patients in renal transplant at AIIMS 🏥

🔥when do you call a patient immunologically high risk ? 🔴 ImageImage
🔥 IL2 receptor blocker versus No induction

🔥 ATG versus Basiliximab ImageImage
🔥 different immunosuppressive protocols Image
🔥 very crucial concluding points Image

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More from @Jithukurian6

Jithu kurian🇮🇳 Profile picture
Apr 28
🔥 Points on transplant immunology by Prof. Dr. Jeremy Chapman Image
🔥 the Complement dependent cytotoxicity (CDC) test

🔥 Donor lymphocytes + recipient sera + compliment

🔥 the cells which die due to complement mediated cytotoxicity via recipient antibody binding to donor HLA allow the dye to enter inside and gives itself a red colour ImageImage
🔥 flow cross match

🔥 Gating of Lymphocytes —> labelling to B and T lymphocyte —> Flouroscein isthiocyanate labelled anti human Immunoglobulin Image
Read 8 tweets
Jithu kurian🇮🇳 Profile picture
Feb 14
🔥Had a small presentation (12 min ) on Rituximab in ANCA vasculitis . Few things I learnt while making it
🔥How do we know that B lymphocytes play a prominent role in pathogenesis of ANCA vasculitis ?
🔥 how does the CD 20 receptor - the site of action of Rituximab look like ?

🔥 what does the xi in Rituximab stand for ?

🔥 what’s the target CD 19 cell count we target for ?
Read 22 tweets
Jithu kurian🇮🇳 Profile picture
Aug 8, 2020
Hi every one , once again back with nephrotic syndrome

What is steroid dependent nephrotic syndrome ? 🤔🤔

Its two 2⃣ s

2⃣ consecutive relapses while on steroid therapy or

within 2⃣ weeks of stopping steroids
What are the steroid sparing agents in steroid dependent nephrotic syndrome in children 👶? 🤔🤔

👉🧨I always had difficulty in getting this numbers right as a resident 🤫🤫 so , lets revise 😀
👉 Oral cyclophosphamide💊➡️2.5 mg /kg / day for 8 -12 weeks

👉 To be given only after remission with steroids is
attained

👉Not to be repeated for the second time 💊💊❌

👉 Max cumulative dose – 168 mg/kg 💀

👉Better response for frequent relapse than in steroid dependent
Read 7 tweets

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