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Swapnil Hiremath @hswapnil@med-mastodon.com Profile picture
@hswapnil
Apr 29 • 6 tweets • 5 min read Twitter logo Read on Twitter
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Tony @tony_breu holding court on renal physiology in ATN at #ApExPathshala
Is TGF in ischemic ATN good or bad? Image
The seminal paper of course is Klaus Thurau on Acute Renal Success
#ApExPathshala pubmed.ncbi.nlm.nih.gov/961698/ ImageImage
Without TGF, we would not have Acute Renal Success, we would have ‘complete renal failure’
@tony_breu At #ApExPathshala Image
To summarize, oliguria in ATN is a bunch of reasons
@tony_breu at #ApExPathshala Image
The obligatory #Tweetorial on the topic of decreased GFR in ATN

#ApExPathshala

As an aside - if you thought his #tweetorials are wonderful - watching @tony_breu in live action is a treat. What an engaging & engrossing educator!
#ApExPathshala Image

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More from @hswapnil

Swapnil Hiremath @hswapnil@med-mastodon.com Profile picture
Apr 29
JC @VelezNephHepato blows up the IAC criteria for defining #Hepatorenal syndrome

Really impractical and not useful
#ApExPathshala Image
Interestingly enough, norepinephrine is possibly very similar to Terlipressin in hepatorenal syndrome as long as the MAP goes up (which is key!) @VelezNephHepato at
#ApExPathshala Image
Don’t miss abdominal compartment syndrome
@VelezNephHepato dates himself by mentioning this entity didn’t exist when he went to med school (neither for me 👴🏻
#ApExPathshala Image
Read 5 tweets
Swapnil Hiremath @hswapnil@med-mastodon.com Profile picture
Apr 28
The #Tweetorial guru @tony_breu up next with a fresh tweetorial presentation (he will post it tomorrow for the rest of you)

#ApExPathshala Image
Tony @tony_breu walking us through his research that underlies a single tweetorial

It’s intense.

Why? is a tough question.

#ApExPathshala
This was a master class of physiology with several citations and lots of data and logical thinking 🤯

Watch out for @tony_breu tweetorial to drop in a few hours.

#ApExPathshala
Read 4 tweets
Swapnil Hiremath @hswapnil@med-mastodon.com Profile picture
Oct 19, 2022
Published! (Months after being FDA approved) by @IgAN_JBarratt et al

The phase 3A part of targeted release budesonide (called Nefecon) in IgA

kidney-international.org/article/S0085-…

They included IgA with proteinuria > 1g and GFR 35 to 90 + max supported RASi

see how that worked out:

1/ Image
Safety on all presented (note more AEs in Nefecon group)

Efficacy on those with 9 month follow up

2/ Image
Proteinuria goes down nicely with Nefecon aka budesonide

3/ Image
Read 9 tweets

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