* should be repurposed as an effective drug for clinical treatment of patients with NASH-fibrosis or liver cirrhosis
* has known efficacy for reversing steatohepatitis and steatosis (which can also result in liver cirrhosis)
* reverses &...
@drarce@Aimee365247 & prevents collagen deposition induced by oxidative stress in non-fibrotic stellate cells
Niacin regresses collagen content in human hepatic stellate cells from liver transplant donors with fibrotic non-alcoholic steatohepatitis (NASH) ncbi.nlm.nih.gov/pmc/articles/P…
"Liver mitochondrial extracts were prepared from wild-type and SIRT5 KO fed mice, and CPS1 activity was determined by measuring conversion to citrulline colorimetrically.
As expected, activity was dependent on the essential co-factor, NAG"
@drarce@Aimee365247 "Intramuscular injection of niacin in normal rats induces hyperglycemia which lasts approximately 1 hour. In adrenalectomized rats niacin produces a hypoglycemia."
"Bera showed (10) that the rise in blood sugar after niacin injection is due to liberation of adrenaline from the...
Nicotinic acid treatment shifts the fibrinolytic balance favourably and decreases plasma fibrinogen in hypertriglyceridaemic men academic.oup.com/eurjpc/article…
Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT) sciencedirect.com/science/articl…
“An uncontrolled clinical trial in 39 hypertriglyceridemic patients with steatosis showed reduction of liver fat by 47% and reductions in liver enzymes and C-reactive protein from the baseline when treated with niacin”
"In our study, high niacin intake during lifestyle intervention was associated with a larger reduction of liver fat content without affecting insulin sensitivity"
“Among 58 subjects with nonalcoholic fatty liver disease (NAFLD) at baseline, NAFLD resolved in 23 subjects during…
… the lifestyle intervention. For 1 standard deviation increase in niacin intake, the odds ratio for resolution of NAFLD was 1.77 (95% CI, 1.00–3.43). High niacin intake has a favorable effect on the reduction of liver fat during lifestyle intervention"
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration | Cell Death & Differentiation nature.com/articles/cdd20…
Flush niacin (nicotinic acid and its metabolites like nicotinic acid mononucleotide and nicotinic acid adenine dinucleotide) = good
Nicotinamide mononucleotide (NMN and NR and nicotinamide) = bad
… Supplementation of nicotinic acid and its derivatives up-regulates cellular NAD+ level rather than nicotinamide derivatives in cultured normal human epidermal keratinocytes
"The researchers are next planning to study epigenetic and metabolomic features related to exposure using integrative omics to help describe which biologic pathways are disrupted among Parkinson’s patients who experienced pesticide exposure."
Just a measly 53 mg of niacin supplemented daily was recently proved in @BioMedCentral to HALVE cancer mortality (=extend (more healthy) life by double)
^ And even more recently in @Nature, it was shown that "NAD+ precursor, vitamin B3 niacin, efficiently corrects tissue NAD+ levels, improves mitochondrial metabolism and ameliorates cancer- and chemotherapy-induced cachexia”
Dietary nicotinic acid supplementation improves hepatic zinc uptake and offers hepatoprotection against oxidative damage | British Journal of Nutrition | Cambridge Core cambridge.org/core/journals/…
How come our hero Zelenko never told us that? Instead pushed Nazi nerve agent HCQ aka “sulphas”/“sulfas”, which they put in the jabs (along with ivermectin aka Strep-) to further deplete & disable flush niacin + N-acetylglutamine?!?!?