I continue to see talks of high unexplained excess deaths in England and Wales in S1 2023
This is NOT confirmed by data by occurrence date and is an artefact resulting from
/ reporting by registration date
/ policy of only registering deaths once cause is assigned
THREAD
Just to make my point crystal clear
The S1 2023 deaths by registration date excl covid are POSITIVE and high which signals lots of unexplained deaths
Yet, when using deaths by occurrence date (as one should), the same total is NEGATIVE. So in fact no/few unexplained deaths
1/
If you think that this effect is just the result of the fact that I used the ONS baseline which is not a proper choice
The same conclusion holds true when using the approach that CMI proposes (ie based on 2019 mortality rates and adjusted for population development)
2/
Why is this so? Because of TWO main factors
Factor 1: The huge wave at the end of 2022 led to an unusually high amount of 2022 deaths being registered in 2023 (I estimate 7k more than in previous years)
So deaths by registration inflate the true death toll in 2023
3/
But that's not the end of the story: There is a 2nd more pernicious factor playing here
E+W is unique in that it only registers deaths once cause of death is assigned
Other countries register unclear deaths under a temporary ICD code and correct it once the cause is clear
4/
The weakness of the E+W system is that deaths that require to go through coroners (as is often the case in younger age bands) can take a year or more before they get registered
So the death data by occurrence date takes much longer to be complete
5/
Just to illustrate the magnitude of the issue: I found some data by age and occurrence for England
It shows how, at the end of May 2023
/ the last 18 months of the 15-44 data
/ the last 6-9 months of the 45-64 data
were essentially materially incomplete
6/
Here another way to show this based for the 15-44 age band
In 2022, ONS shared the same dataset by occurrence for deaths registered up to May 2022
If you compare it with the dataset with deaths registered up to May 2023, you see how the data diverges over the last 18 months
7/
The registration date for many deaths in younger age bands will be MUCH later (up to 18 months) than death occurrence
This means that the data by registration date will not reflect the timely pattern of the deaths in these age bands (compare blue and black line)
8/
But as, I explained yesterday, this has other consequences: If, as is likely in a pandemic, there are MORE deaths going through coroners, then X months later, deaths by registration will see a (fake) increase
And this is what I suspect is currently happening in 2023 as well
9/
Unlike previous years, there were much more deaths registered in May-Jun 2023 than occurred
(the deaths occured is the result of an estimate made by ONS which corrects for lag and is quite precise at top level)
10/
As I show here, this means that almost all the excess mortality seen in the data by registration date in May-Jun 2023 is the result of deaths that occurred before May
It took me quite a while to understand why deaths by registration were so off vs. the actual situation
What happens is that registration-based data is quite robust if one year is like another (as it was pre-pandemic)
12/
However, if, as is the case in a pandemic, there are "one-off" and lots of unusual events, constraints on registration capacity, etc., the data by registration date starts to be driven by noise instead of underlying death occurrences
And this what we are currently seeing
13/
So deaths by registration date are currently not suited for analysing excess mortality in England+Wales as it is affected by
/ much higher than usual spillover from 2022 to 2023
/ likely catch-up of past occurrences only registered now
/ timely noise in younger age bands
END
@AdeleGroyer (by significant, I mean 1-2% which is essentially within band of uncertainty)
That's why I was getting more and more concerned about the difference of message between registration date data and occurrence one
But happy to be proven wrong, as you know! :-)
@AdeleGroyer And of course, just to be clear: no topline excess does not mean no excess: It could well be that there is negative excess in older age bands and more positive in younger ones
Here the data from the 65-84 which is pretty complete up to Mar 23 and there is no excess before covid
NB: I put this thread on hold until I clarify seemingly contradictory elements
/ I find the ONS modelled deaths remarkably accurate
/ However, they imply an unrealistic shortening of the death registration lag
More to follow once I understand what's happening
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A little example to show well the assumptions of the Ioannidis "Lives Saved" study fit reality
- Take its IFR estimates
- Get the US MCOD covid deaths from CDC up to 14/11/20
- Calculate infx up to 31/10/20
Result? The study estimates that the US infx rate was 62% by 31/10/20😀
Now I took end October 2020 out of a reason: There are two sera studies for the US at that date
a) CDC: 8%
b) another study: 11% (side comment: actually 5% but then doubled for serareversion which is far too much)
I did the following:
- I took the sera studies considered as good by Ioannidis in his paper on IFR from 2023 for West Europe (incl DE/FR/SP/IT/PT/AT ...)
- I matched that with the info I have on covid deaths per certificate
Result? Covid IFR was >1% in Western Europe in 2020
Ioannidis published a piece early 2021 in which he selects 40 sera studies which he considers as good
I just went through them and focused on those that concern western Europe
This covers DE, FR, IT, SP, PT, AT, IR and NO so quite a lot!
1/
And the result is simple: All datapoints are with IFR >1%
(I am still trying to figure out a way to add more info on each data point / will be for an addendum later)
The conclusion on lives saved depends on the severity of Omicron vs. Delta and Wuhan
By chance, Omicron proved much less intrinsically severe than Delta ... but we couldn't know this in 2021
So the study's conclusions on the legitimacy of measures are based on hindsight
2/
The correct way to do this analysis would be to
- include the full range of assumptions incl. real life data, ie IFR 2-5x higher, efficacy 50%-80% higher, etc.
- make the legitimacy of actions based on the options for Omicron's potential severity AS VIEWED from mid 2021 data
3/
Only the UK had a good idea of its infections and yet I am not aware of a single study using it to determine IFR of covid by age
A study was published today by Ioannidis et al on lives saved by vaccines and their IFR is massively lower than the real data based on from the UK
1/
Ioannidis et al rightly split the 70+ into community and care settings
I applied both to the population of England and Wales assuming 400k care places and hence 800k people of the 70+ (average stay = 2 years) exposed to covid via care settings
2/
So of course this will massively impact estimation of lives saved from vaccines (and impact multiple other analyses and post-mortems of the pandemic management)
This study looks well done but I don't see how it allows for "concerns about vaccines" as conclusion line
To take an analogy, if a study found higher car mortality in men than women wearing a seat belt, you would not expect "concerns about seat belts" as conclusion line
I asked the authors about it also because, actually all studies of age-adjusted mortality by vax status show a higher rate among the unvaxed
So, without further further info about unvaxed, the conclusion to date here is that Moderna reduced mortality even more than Pfizer
2/
I may be missing something here of course and I put my surprise on the conclusion line to the authors
But I like the study itself on the comparison between the two vaccines as the authors spent a lot of efforts, as it should, to avoid confounders between their two groups
If you are in covid twitter, you will see this headline pass your tweet today
"Quasi consensus in the French Medical academy for a lab origin of covid" relayed by the normally very serious @Sciences_Avenir periodical on science
Only issue? It is not true...
@Sciences_Avenir What happened is that the academy
- got a presentation on a report of the covid origin, available here
- was asked to approve the conclusions of the report (see screenshot) which are on the measures to minimize lab risks NOT ON THE ORIGIN OF COVID ITSELF
The report goes through the usual points in favour of animal and lab origins of covid
Then, sensibly, the report concludes: "we will never know for sure for covid but we need to make sure to minimize any risk, including lab risk"