Siim Land Profile picture
Jul 25 11 tweets 3 min read Twitter logo Read on Twitter
Prehydrating with salt before exercise is the best pre-workout you could ever have

It is able to increase your performance by 10-20x more than any other supplement⬇️⬇️ Image
One of the limiting factors for physical performance is high core temperature - as you start exercising your core temperature starts increasing - and you bonk when it gets too high

As core temperature rises, blood flow shifts to the skin and reduces blood flow to the muscles
Boosting blood volume prior to exercise which is most effectively done with salt and water provides the body with a larger amount of circulating fluid to offload heat and cool the body

It also slows the rise in core temp, reducing sweating and electrolyte loss during exercise
There have been several studies that have tested pre-loading with salt solutions prior to exercise to boost blood volume


https://t.co/Wsv1xIBTiz
https://t.co/0bK6Xar9gj
https://t.co/wGDje30KDHpubmed.ncbi.nlm.nih.gov/17218894/
pubmed.ncbi.nlm.nih.gov/9561285/
pubmed.ncbi.nlm.nih.gov/11417429/
pubmed.ncbi.nlm.nih.gov/17463297/
In 13 trained female cyclists, they cycled at 70% of VO2 max at 32°C until exhaustion

1st grp took a high-salt (2,368 mg sodium) solution
2nd grp took a low-salt (144 mg sodium) solution

Both were ~ 21.6 oz of fluid, consumed over 60 mins, 1 hour and 45 mins before exercise
On average those drinking the high-salt solution were able to cycle 20.1 minutes longer (PMID: 17463297)

the best workout supplements, such as beta-alanine or beetroot juice, only increase exercise duration by 1-2 mins
Similar benefits were found in 8 trained male runners running to exhaustion at 70% of VO2 max in 32°C

2,855 mg of sodium vs. 174 mg of sodium in 25.6 oz

On average those drinking the high-salt solution were able to cycle 20.8 minutes longer (PMID: 17218894)
To summarize, high-salt solutions before exercise in heat have been shown to:
1. Increase exercise duration by ~20-21 minutes
2. Lower heart rate lower by 9-10 beats per minute
3. Lower core body temperature by 0.4°C
4. Reduce feelings of fatigue
Part of the benefits of prehydrating with salt is it postpones the rise in core temperature that occurs during exercise

At a core temperature of 38°C, performance starts to decline, and once an internal temperature of 39°C is reached, performance will eventually cease.
Here's the hydration formula by @drjamesdinic for peak performance:

An hour before training

- Preload with salt, water, and glycine

(2,300-4,300 mg sodium + 4-8 grams of glycine in 22-33.8 oz. of fluid, respectively) Image
Learn more performance secrets from my book with @drjamesdinic and @mcgregorfast nutritionist Tristin Kennedy called WIN

Foreword by @bengreenfield

amzn.to/3QhfdO9

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More from @siimland

Jul 21
MAGNESIUM CHEAT SHEET⚡:
- Taurate: heart and blood pressure
- Threonate: brain and memory
- Glycinate: relaxation and sleep
- Citrate: constipation
- Lactate: digestion
- Malate: energy and fatigue
- Chloride: blood sugar and digestion
- Orotate: heart
- Sulfate: muscle soreness Image
The top 3 best magnesium forms:
- Glycinate (safest/cheap)
- Threonate (highest bioavailability for the brain)
- Taurate (safe and effective for the cardiovascular system)
The top 3 worst magnesium forms:
- Oxide (low bioavailability/contaminated)
- Carbonate (low solubility)
- Citrate (can cause diarrhea)
Read 6 tweets
Jul 18
Sauna use is one of the oldest biohacks that can promote your longevity:

- 63% lower risk of sudden cardiac death
- 63% reduced heart disease mortality
- 46% lower risk of hypertension
- 40% reduced all-cause mortality

And much more (THREAD) Image
Sauna use has many preventive effects on cardiovascular disease, hypertension, diabetes, neurodegeneration, and other chronic diseases (Patrick et al 2021)

Sauna mimics a lot of the benefits of exercise through hyperthermia and heat shock proteins Image
Saunas are basically sweat lodges or small rooms that are heated up to high temperatures.

The high temperature starts heating up your body, causing mild hyperthermia. Hyperthermia has benefits on immune and cardiac function (PMID: 3132509) Image
Read 20 tweets
Jul 15
Glycine + NAC (GlyNAC) supplementation shows promise in being great for longevity and increased healthspan:

- increased antioxidant defense via glutathione
- reduced inflammation
- reduced hallmarks of aging
- better immune system
- protects the heart, brain, liver and bones Image
A 2023 randomized clinical trial found that supplementing GlyNAC for 16 weeks in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and 7 hallmarks of aging (PMID: 35975308)
The authors claimed: "Only GlyNAC supplementation in older adults resulted in significantly improved (a) glutathione concentrations by 121% after 2 weeks, and by 164% after 16 weeks to levels not different from younger adults"
Read 9 tweets
Jul 14
Glycine has a lot of benefits for longevity

1. Mimics methionine restriction
2. Increases autophagy and glutathione
4. Collagen synthesis
5. Inhibits advanced glycation end-products (AGEs)
6. Lowers blood sugar
7. Promotes good sleep quality

* Taking collagen is not enough Image
Glycine is considered a non-essential amino acid because the body can synthesize it

The body can make only 3 grams of glycine a day, which is far from what's considered optimal for collagen turnover or other vital functions like glutathione, creatine, and heme synthesis
Here's how much glycine your body would optimally need:

1. You need 3 grams of glycine for creatine, glutathione, and heme synthesis

2. For collagen turnover, you need at minimum 12 grams of glycine

So, at minimum, you need 15 grams of glycine a day Image
Read 15 tweets

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