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Study from Basel, Switzerland that looks at myocardial injury as measured by routine measurements of cardiac biomarker (HsTn) after healthcare employees received a booster.
Obvious big limitations :
https://t.co/Gdffqn93jSonlinelibrary.wiley.com/doi/epdf/10.10…
Obvious big limitations :
https://t.co/Gdffqn93jSonlinelibrary.wiley.com/doi/epdf/10.10…
1. Excludes anyone who had myocarditis after dose 1 or dose 2
2. No baseline troponin checked prior to booster administration
3. 1871 Screened ---> 777 evaluated in trial
4. Average age 37, only 30% male
(Peak clinical myocarditis to date has been seen in 16-17 year old boys)
2. No baseline troponin checked prior to booster administration
3. 1871 Screened ---> 777 evaluated in trial
4. Average age 37, only 30% male
(Peak clinical myocarditis to date has been seen in 16-17 year old boys)
But still super useful to see how "cardioactive" booster is, grateful to researchers for taking a look.
20 women and 2 men had HsTn levels that were above the population reference ranges.
Most had repeat troponin levels done at 30 days (makes up a little for no baseline)
20 women and 2 men had HsTn levels that were above the population reference ranges.
Most had repeat troponin levels done at 30 days (makes up a little for no baseline)
A bit hard to tell what the significance of these troponin elevations are. If we assume 30 day troponin is close to baseline than 7 of the 20 women have elevated troponins at baseline.
There is one woman that appears to have a markedly elevated troponin relative to baseline
There is one woman that appears to have a markedly elevated troponin relative to baseline
Everyone else really doesn't have that significant of a troponin change.
Not surprisingly, then, there is really nothing clinically concerning at 30 days to report.
Sample here is small, but a similar Thai study of highschool kids had a 1% (3/301) rate of myo/pericarditis
Not surprisingly, then, there is really nothing clinically concerning at 30 days to report.
Sample here is small, but a similar Thai study of highschool kids had a 1% (3/301) rate of myo/pericarditis
Thai study was with Pfizer , this study is with Moderna (3x the mrna dose of Pfizer), so this seems to suggest the booster version of the mrna vaccines (no longer available now that bivalent vaccine is out) doesnt cause significant cardiac injury in this mostly female group..
There were only ~230 men in this study, which is way too small.. . Just means rate of significant myocarditis , or even subclinical myocarditis is < 1/230 in men.
Given the recommendation is to give these vaccines to basically everyone, and that health young are at very low risk of severe illness from COVID now... really would need bigger studies to feel better about safety.
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