Edward Nirenberg 🇺🇦 Profile picture
Jul 29 5 tweets 2 min read Twitter logo Read on Twitter
Hi US friends- there is a clear rise in SARS-CoV-2 in wastewater, suggesting a rise in cases and all the things that accompany that (). A reminder of some things you can (still) do to help reduce the risk of COVID:
1. Ensure you and your loved ones are... https://t.co/0XeN2VSUkibiobot.io/data/covid-19

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up-to-date on vaccination (vaccines based on XBB.1.5 spike will be available in the Fall, so it may be more practical to wait until then for low-risk individuals; questions about YOUR situation should be directed to YOUR primary care team ± specialist).
fda.gov/vaccines-blood…
2. Maximize air quality in indoor spaces you spend prolonged time in, meaning increasing circulation of the air and also ensuring relative humidity of 40-60% (including while sleeping).
3. Wear a high-quality respirator (e.g., N95) in indoor public spaces that ...
you may need to be present in for long periods of time.
4. Make sure you have a stock of tests that you can use before gathering, especially if the gathering is large and includes vulnerable people.
5. Don't attend gatherings if you feel unwell, even if your test is negative.
6. Discuss options for antiviral therapies (e.g., Paxlovid) with your primary care team or specialists.

COVID is not the threat it was pre-vaccine, but it's still here and can still occasionally cause serious harm, including long COVID. Avoiding infection is ideal.

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More from @ENirenberg

Jul 20
In other cool vaccine news, I present this paper whose results surprised me:


A thread with a primer on how mRNA vaccines actually work 🧵nature.com/articles/s4156…
There are a few aspects to our mRNA vaccines that give them such excellent immunogenicity. One of these is the use of modified RNA using N1-methylpseudouridine instead of uridine in the sequence. See:
This prevents the RNA from being recognized by TLR 7 and 8 (which sense single-stranded RNA but differ in their expression across cells), and reduces recognition by TLR3 (which senses double-stranded RNA).

https://t.co/XQB11FzMwE
https://t.co/hAlL3BxiFJ https://t.co/ZRoyWkPN1Kpubs.acs.org/doi/10.1021/ac…
cell.com/immunity/pdf/S…
ncbi.nlm.nih.gov/pmc/articles/P…
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Read 25 tweets
Jul 5
I see that the usual suspects are misrepresenting the reasons for some countries' refusal to include varicella (VZV, chickenpox) as part of the routine childhood immunization schedule, so in this thread: febrile seizures. 🧵

First a bit of housekeeping though on VZV vaccines.
The major reason some countries don't include varicella vaccination on the schedule is because of the Hope-Simpson hypothesis, arguing that if older adults do not get boosted by exposure to VZV (from children), they are at higher risk of shingles:
https://t.co/dV2thUbeHKox.ac.uk/research/every…
As I have made clear before, while this concern does have merit, the US's 25-year-long experience with varicella vaccination in children has not substantiated what these models predicted- the feared surge in shingles has not happened.
https://t.co/rPVqr5BWe5academic.oup.com/jid/article/22…
Read 24 tweets
Jun 29
For anyone who cares, I went through Kennedy's Town Hall to look at what he says about vaccines over a period of about 10 minutes. Quite literally every single thing he claimed about vaccines was either completely inaccurate or lacked key context. 🧵
Immediately Kennedy rejects being called anti-vaccine and claims it is pejorative and intended to silence him. Lest we forget:


There's also the time he sparked a measles outbreak which he tried to blame on the vaccine:
https://t.co/Lbx6kArGUO
arstechnica.com/science/2019/1…
Oh and then there's also this:


The only way you could sincerely argue that Kennedy is not anti-vaccine is if you were to invent a term that expresses an even greater opposition to vaccines than being anti-vaccine.arstechnica.com/science/2019/1…
Read 39 tweets
Jun 28
I don't even know how to discuss this because the conduct is so disgusting but Alex Berenson is lying again and desecrating the memory of Grant Wahl to make his point so I guess I'll be as brief as I can about it. 🧵
Berenson is misrepresenting 2 studies alleging that there is a massive hidden death toll from mRNA vaccination and that the anti-vax propaganda of Died Suddenly has a point (it doesn't: ).

Here is the first study:
https://t.co/IPM1luoNREapnews.com/article/vaccin…
academic.oup.com/eurheartj/arti…
In it, we find that of 44 million people who got COVID-19 vaccines, 480 had some form of myocarditis (~1 in 100,000), and of these 95 cases were severe (~1 in 500,000) and there were 8-22 deaths as a result of the myocarditis (1 per 2-5.5 million).
Read 11 tweets
Jun 23
The vast majority of flu vaccines used in the 2022-2023 season were thimerosal-free and you can ask for thimerosal-free vaccines if this sort of thing matters to you so this is really a moot point.

. https://t.co/YLJJXsOxKb https://t.co/WtFG9Gt8Chcdc.gov/flu/prevent/va…

Having said that, the abuse of really basic chemistry to lie to the public does grow old. Thimerosal is a preservative- it is included to prevent contamination by microbes that would occur from using multidose vials of vaccine. There is a very strong precedent for its necessity.
Before preservatives, the use of multidose vials resulted in multiple devastating infections from vaccination. A lack of preservatives in these vaccines was literally killing people.
https://t.co/WP1Z6pvfRvncbi.nlm.nih.gov/pmc/articles/P…
Read 18 tweets
Jun 22
Good lord- RFK Jr. claimed on Rogan’s podcast that there is good evidence that the flu vaccine caused the 1918 Spanish Flu epidemic. Slight problem with that claim: influenza had not even been identified until the 1930s and a flu vaccine wasn’t available to the public until 1945.
Like seriously this is farcical. It really is always the vaccines and it never not the vaccines for these people.
I would be remiss not to mention that it is not possible for you to get flu from the flu vaccine
Read 6 tweets

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