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T. Ryan Gregory Profile picture
@TRyanGregory
Jul 30 • 15 tweets • 4 min read Twitter logo Read on Twitter
On anti-viral nasal sprays. 🧵

I've used Enovid as an additional layer (e.g., when travelling or in an unavoidable crowd).

Enovid (aka VirX, aka SaNOtize) is nitric oxide.

sanotize.com/technology/our…
There is research to suggest that nitric oxide nasal sprays (NONS) can be effective, though additional trials are still ongoing.

pubmed.ncbi.nlm.nih.gov/?term=nitric+o…
financialpost.com/pmn/press-rele…
Nitric oxide sprays aren't approved for sale in many countries yet (including in places where they were developed!), but they can be ordered online. For example, Enovid is available from Israel. Trouble is, they're quite expensive.
There are other products out there that claim to be effective, but I am not sure whether there is research to back this up.

Have you used nitric oxide? Are there other products that have shown promise in real trials? Let us know.
Some other options listed below for which there is at least some supporting data. I am just listing them, haven't tried them, not endorsing or recommending them...
Viraleze

viraleze.co/how-it-works/
Xclear

businesswire.com/news/home/2023…
Azelastine

mayoclinic.org/drugs-suppleme…
There are also several studies that suggest benefits of simple saline nasal rinses (e.g., neti pot or other devices). If you do this, *boil the water first!* (and let it cool, obvs) -- you don't need a brain-eating amoeba on top of everything else.

frontiersin.org/articles/10.33…
There are also options based on carrageenan derived from algae. (e.g., Flo Travel).

ncbi.nlm.nih.gov/pmc/articles/P…
Some sprays contain ethyl lauroyl arginine hydrochloride (ELAH), such as Covixyl.

news-medical.net/news/20220315/…
There are sprays that contain povidone-iodine, but the literature seems a bit mixed on effectiveness. Examples include Viraldine and Nasodine.

classic.clinicaltrials.gov/ct2/show/NCT04…
Some nasal sprays marketed for colds are readily available and might be effective against SARS-CoV-2 (though data are limited). For example, Vick's Early Defense has been tried.

medicaldevice-network.com/news/pg-health…
A review of different nasal spray formulations:

ncbi.nlm.nih.gov/pmc/articles/P…

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More from @TRyanGregory

T. Ryan Gregory Profile picture
Jul 30
Open access tools for tracking variant evolution and frequencies. 🧵 of 🔗
Nextstrain:



This resource lets you track the evolution of SARS-CoV-2 variants in real time as data come in. I've written a thread on how you can use it:

https://t.co/laRx1pcxUBnextstrain.org/ncov/gisaid/gl…
CoVariants:



A detailed summary of information about the mutations found in different variants.covariants.org
Read 15 tweets
T. Ryan Gregory Profile picture
Jul 30
A few links on Corsi-Rosenthal boxes. 🧵
Corsi-Rosenthal Box Foundation:

corsirosenthalfoundation.org
Excellent Corsi-Rosenthal Box resources from Clean Air Crew:

cleanaircrew.org/box-fan-filter…
Read 5 tweets
T. Ryan Gregory Profile picture
Jul 30
Going to keep a 🧵of 🔗 for posts about tools for COVID-aware folks. Feel free to bookmark and comment on any of the individual threads.
GENERAL TOOL LIST

CO2 METERS

General overview:

Read 17 tweets
T. Ryan Gregory Profile picture
Jul 29
What will happen with COVID in fall?

Speaking mostly of Canada here, but some of the general points should be applicable in various places. 🧵

1/
Recall that XBB (Gryphon) did not cause a huge wave on its own. XBB.1.5 (Kraken) was the first recombinant variant to become globally dominant, but it likewise did not cause a big wave on its own (as we said it probably wouldn't).



2/
What the XBBs did was take over from BA.5s/BQs in keeping the baseline high in Canada for over a year beginning in summer 2022.

BA.1 and BA.2 caused tsunamis. BA.5/BQs/early XBBs drove sea level up, with high and low tides around that high baseline.



3/
Read 18 tweets
T. Ryan Gregory Profile picture
Jul 27
I decided to pick up a few more of the cheap mini CO2 meters for members of my family to carry with them. A quick 🧵 of 🔗 about these.

(Best place to get them is from @DonateMask.)

shop.evidencebased.ca/collections/mi…
First, a few thoughts about CO2 monitors generally.

Remember that CO2 is a) only a rough proxy for COVID risk, but b) a health issue in its own right.

Read 16 tweets
T. Ryan Gregory Profile picture
Jul 23
I've been asked what I think of the planned update to monovalent boosters that target XBB.1.5 (Kraken), which will be the case for Pfizer, Moderna, and Novavax. 🧵

1/
I think updating boosters is a good idea. The existing options target either Wild Type + BA.1 or WT + BA.5. BA.1 hasn't been in wide circulation since the first Omicron wave, and BA.5 (and descendants like BQs) mostly fizzled out around the world after the XBBs took over.

2/
The notable exception is the massive wave in China (> 1 billion infections) which was driven by BA.5s. There is now a second XBB* surge there, which raises the strong possibility of recombinants of BA.5s x XBBs.

3/
Read 14 tweets

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