Siim Land Profile picture
Aug 4 21 tweets 8 min read Twitter logo Read on Twitter
I have one of the slowest speeds of aging in the world - 0.62

@bryan_johnson Rejuvenation Olympics has the lowest score of 0.677

I'm going to have to wait until October to do my 3rd test and qualify for the leaderboard

Here's my protocol⬇️⬇️ Image
I did the Dunedin PACE test that measures your speed of aging based on DNA methylation

The results are based on your chronological age cohort, which for me is 28

My score of 0.62 is better than 99% of other people my age

The average 28yo would have a score of ~0.85-0.90 Image
3 years ago I took my first DNA methylation age test based on the Horvath's clock of aging

I got the age of 16 at a chronological age of 25

I took the same test again at 28 years old and the scored 16 still

My DNA methylation aging rate based on this is 0.56
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So, what's my protocol?

I've been following my biohacking routine for 6 years and have honed it towards longevity over the past 3 years or so

Some of the fundamentals are obvious:
- exercise regularly
- keep an optimal weight
- sleep well
- circadian rhythm
- some supplements
I'm in excellent health by all metrics:
- chronological age 12 years younger (I'm 28)
- all biomarkers great
- optimal body composition
- advanced fitness metrics

And I've achieved it with:
- no pharmaceuticals, I take only OTC supps
- no TRT/injections/peptides/PEDs Image
What's my diet like?

Not very restrictive, I do adhere to a decent calorie deficit but I do more like calorie & carb cycling i.e. higher carbs and calories on workout days and less on rest days

You can check out my full diet breakdown in this video:
What foods do I eat?

Almost all food groups, including vegetables, fruits, tubers, meat, fish, eggs, dairy, some grains

Check out my fridge breakdown:
I've been doing intermittent fasting for 10 years all the time

I've done 16/8, one meal a day, etc

The last 6 years I've been doing what I call Targeted Intermittent Fasting: 1 protein shake before a workout and then a bigger meal

https://t.co/gvxGhWCeXs
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What's my workout routine?

I lift weights, do calisthenics a lot but also incorporate a lot of cardio/HIIT

Full breakdown:
I measured my VO2 max for the first time ever a few weeks ago and got 53, which is decent and above the threshold for lowest mortality risk but I haven't trained a lot for VO2 max so far

Higher VO2 max is one of the best predictors of mortality and I intend to get mine to 60 Image
My strength, which is second best for mortality risk, is quite advanced however

Here's me doing a weighted pullup with 88 kilograms on my belt at a bodyweight of around 83 in the video
Everyone's always interested in supplements, although I believe the body composition, strength, and VO2 max are much more powerful

In total, I take maybe 15 supplements a day

No peptides, no injectables, only OTC

Full video:
Some of the biggest bang for your supplements for longevity and slowing speed of aging in my opinion are:
- glycine + NAC
- TMG
- creatine
- glucosamine
- melatonin
- collagen peptides
I have excellent resting heart rate and HRV
- heart rate usually at 36-38 beats per min
- heart rave variability (HRV) usually around 120 Image
I attribute my low heart rate and high HRV mostly to:
- doing cardio and walking
- being in good weight
- keeping stress low
- regular saunas and cold exposure

I've taken the sauna since 1 years old (I'm from Estonia) and it's one of the best for HRV
My sleep is also quite good - getting scores of 90-100 on my EightSleep mattress

I do sleep around 7-7.5 hours on average and sometimes even 6.5 hours

Ideally, I would want to sleep 8 hours on average but I'm experiencing no side-effects from 7-7.5 atm Image
Some key hacks that I think have helped me to achieve a very slow speed of aging compared to my peers and other biohackers:
1. Intermittent fasting
2. High methyl donor diet (beetroot, eggs, leafy greens, etc)
3. High frequency workouts (5-6x a week)

How much has it cost me?

Not that much - I spent around $1500 per month

I definitely don't have as thorough of a measurement panel or screening of all my organs as Bryan Johnson

But given all my metrics and bloodwork, I'm probably doing great

Video:
If you're seeing me for the first time, then I've been doing biohacking content for many years

My YouTube has over 143k subs, Instagram over 332k followers

I've written and co-authored 8 books about different topics: minerals, athletics, collagen, etc siimland.co/books
I'm in the process of writing my next book about longevity and slowing the speed of aging, which goes into all the details of what I personally do and the results of other people who've worked with me

If you want to stay updated then join my newsletter: siimland.co/vip
Some might think I have good genetics

I have bad genetics for longevity:
- my grandfather died at 36 of cancer
- my 2nd grandfather died at 72
- my grandmoms are in their 70s
- nobody in my family has lived above 80

My family was poor when I grew up - no fancy biohacks Image

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More from @siimland

Aug 2
Glycine has many longevity benefits: antioxidant defense and collagen synthesis, etc

But one of the best longevity effects of glycine is balancing methionine

Excess methionine shortens lifespan in animals and increases the risk of heart disease in humans (PMID: 16487911) Image
Methionine is an essential amino acid needed for survival and protein synthesis

But excess methionine gets converted into homocysteine in the methylation cycle, which is a big risk factor for cardiovascular disease and atherosclerosis (PMID: 25577237; PMID: 33567540) Image
Methionine restriction in animals has been seen to consistently extend their lifespan up to 42% (Sci Rep 12, 5073 (2022))

High dietary methionine intake increases the risk of acute coronary events in middle-aged men (PMID: 16487911)
Read 11 tweets
Jul 27
A new study identified 8 habits that can increase life expectancy by up to 24 years:
1. Being physically active
2. Free from opioid addiction
3. No smoking
4. Stress management
5. Good diet
6. No regular binge drinking
7. Good sleep hygiene
8. Good social relationships Image
"According to the results, men who have all 8 habits at age 40 would be predicted to live an average of 24 years longer than men with none of these habits."
"For women, having all 8 healthy lifestyle factors in middle age was associated with a predicted 21 additional years of life compared to women with none of these habits."
Read 8 tweets
Jul 25
Prehydrating with salt before exercise is the best pre-workout you could ever have

It is able to increase your performance by 10-20x more than any other supplement⬇️⬇️ Image
One of the limiting factors for physical performance is high core temperature - as you start exercising your core temperature starts increasing - and you bonk when it gets too high

As core temperature rises, blood flow shifts to the skin and reduces blood flow to the muscles
Boosting blood volume prior to exercise which is most effectively done with salt and water provides the body with a larger amount of circulating fluid to offload heat and cool the body

It also slows the rise in core temp, reducing sweating and electrolyte loss during exercise
Read 11 tweets
Jul 21
MAGNESIUM CHEAT SHEET⚡:
- Taurate: heart and blood pressure
- Threonate: brain and memory
- Glycinate: relaxation and sleep
- Citrate: constipation
- Lactate: digestion
- Malate: energy and fatigue
- Chloride: blood sugar and digestion
- Orotate: heart
- Sulfate: muscle soreness Image
The top 3 best magnesium forms:
- Glycinate (safest/cheap)
- Threonate (highest bioavailability for the brain)
- Taurate (safe and effective for the cardiovascular system)
The top 3 worst magnesium forms:
- Oxide (low bioavailability/contaminated)
- Carbonate (low solubility)
- Citrate (can cause diarrhea)
Read 6 tweets
Jul 18
Sauna use is one of the oldest biohacks that can promote your longevity:

- 63% lower risk of sudden cardiac death
- 63% reduced heart disease mortality
- 46% lower risk of hypertension
- 40% reduced all-cause mortality

And much more (THREAD) Image
Sauna use has many preventive effects on cardiovascular disease, hypertension, diabetes, neurodegeneration, and other chronic diseases (Patrick et al 2021)

Sauna mimics a lot of the benefits of exercise through hyperthermia and heat shock proteins Image
Saunas are basically sweat lodges or small rooms that are heated up to high temperatures.

The high temperature starts heating up your body, causing mild hyperthermia. Hyperthermia has benefits on immune and cardiac function (PMID: 3132509) Image
Read 20 tweets
Jul 15
Glycine + NAC (GlyNAC) supplementation shows promise in being great for longevity and increased healthspan:

- increased antioxidant defense via glutathione
- reduced inflammation
- reduced hallmarks of aging
- better immune system
- protects the heart, brain, liver and bones Image
A 2023 randomized clinical trial found that supplementing GlyNAC for 16 weeks in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and 7 hallmarks of aging (PMID: 35975308)
The authors claimed: "Only GlyNAC supplementation in older adults resulted in significantly improved (a) glutathione concentrations by 121% after 2 weeks, and by 164% after 16 weeks to levels not different from younger adults"
Read 9 tweets

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