Dr Paddy Barrett Profile picture
Sep 6 18 tweets 5 min read Twitter logo Read on Twitter
Exercise Stress Tests Are Incredibly Useful

Just not for the reasons you might think.

✅Make sure to bookmark 📕

🧵👇

/1 Image
If you are ‘getting your heart checked’

You must do an exercise stress test, right?

Well. Not any more.

Here’s why.

Let’s first state our goal when we are in the business of ‘Heart Disease Prevention’:

/2
"To delay the onset of coronary artery disease (atherosclerosis/plaque) that might rupture and cause a heart attack."

The more plaque you have, the higher the risk of an event such as a heart attack.

And the less plaque you have, the lower the risk of a heart attack.

/3 Image
Do exercise stress tests tell you whether or not you have plaque in your coronary arteries?

No.

They can indicate if there is plaque causing an obstruction to flow down the artery

But they are not looking for the plaque itself.

Doctors know this.

But patients don't.

/4
It is not uncommon for a patient to have a stress test because they are worried about heart disease

‘Pass it with flying colours’ and be told that “All is well”.

Then have a heart attack 3 days later.

How is this possible if they “Passed their stress test”?

/5
Because the stress was not looking for the presence of plaque in the coronary arteries.

It was looking for the presence of an obstruction to flow down the artery.

This distinction is crucial to understand

As most heart attacks occur as a result of non-obstructive plaque.

/6 Image
This is not to say that non-obstructive plaque of less than 70% is more dangerous

It’s just that it is silent and without symptoms.

And it’s also WAY more common.

So you can have a perfectly normal stress test and still have lots and lots of plaque.

/7
Surprised?

You shouldn’t be.

But many people are.

So, is there any value in the information obtained during an exercise stress test?

The answer is yes.

But it’s not related to whether or not you have any plaque in your coronary arteries.

/8
The standard exercise stress test puts you through a series of higher workloads

And is looking for details that might suggest a narrowed artery. ie chest pain or ECG changes.

The report will also include the number of METS you achieved.

/9
MET stands for Metabolic Equivalent of Task and is a measure of the amount of energy you expended during the test.

There is a clear relationship between:

The number of METS you can expend.

And the likelihood of dying from ANYTHING in the near future.

/10 Image
More METs. Longer Life.

Here is a chart you can use for reference, which will also give you an indication of your V02 Max based on the METs achieved.

/11 Image
But what if you start to exercise more to improve that figure?

Does it decrease your odds of dying FROM ANY CAUSE over the following decade?

The answer is Yes.

Increasing the amount of METs you can achieve improves your odds of survival.

/12
Those in the least fit category at baseline who increased the number of METs they could achieve by more than 2 were 33% less likely to die.

Those who lost more than 2 METs were 60% more likely to die.

High-fitness people at baseline benefited the most, with ⬆️ in METS

/13 Image
The trajectory is clear.

Regardless of your baseline fitness level, if you improve it, you increase your odds of survival.

If it gets worse, you decrease your odds of survival.

This is why you need to exercise as if your life depended on it.

Because it does.

/14
“Was my stress test a waste of time?”

The answer is No.

But you need to see it more as an assessment of your functional capacity

And how it changes over time

Rather than a test that looks directly for plaque in your coronary arteries.

/15
There is tremendous value in the information obtained during an exercise stress test.

It's just often not commented on.

The next time you "pass" a stress with 'Flying Colours'

Make sure to ask about the METS you achieved and decide for yourself.

/16
Because even if you didn’t get a good result

You now know what to do to improve your odds.

Time to get to it.

/17
That's a wrap!

If you enjoyed this thread:

👋 You might like to join 10K+ others on my free weekly newsletter on heart disease prevention and living longer.

If so, just click my Bio above and follow the link.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Dr Paddy Barrett

Dr Paddy Barrett Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Paddy_Barrett

Sep 3
Don't use your watch to calculate your V02 max....

You just need 12 mins

And a pair of trainers.

🧵👇

/1 Image
VO2 Max is one of the best longevity metrics we have.

To formally test your V02 max, you need to do a cardiopulmonary exercise test (CPET)

It's worth it but...

If you want to get a reasonable approximation without a mask to measure gas exchange metrics when running?👇

/2 Image
The Cooper Test is a reasonable proxy.

After a warm-up.

You run as fast as you can on flat ground for 12 mins.

You then assess how far you have run.

/3
Read 8 tweets
Aug 30
Do statins cause diabetes?

🧵👇

/1 Image
Life would be so much easier if there were binary, yes and no answers to every question that was important to us.

But there isn’t.

Almost everything comes down to probabilities.

Does speeding cause car crashes?

No.

But it does seriously increase the risk of one.

/2
We could eliminate car crashes entirely by banning driving

But we can all agree that the net harm to society would likely be unacceptable.

It all comes down to:
Your priorities
Your objectives
Your risk tolerance
Your ability to update a risk model

/3
Read 17 tweets
Aug 23
APOE4 does more than increase your risk of late-onset dementia.

🧵👇

/1 Image
Being a carrier of the APOE4 gene variant is associated with higher rates of the most common type of dementia

Late-onset dementia.

There are three primary variants of APOE - APOE2, APOE3 & APOE4.

Everyone has two separate copies.

/2
As a result, there are six different possible combinations.

APOE 2/2, 2/3, 2/4, 3/3, 3/4, 4/4.

Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant.

- 15-20% of the population have at least one copy of APOE4
&
- 2-3% have two copies

/3
Read 19 tweets
Aug 19
Is it possible to reverse coronary artery disease?

I get this question all of the time.

🧵👇

/1 Image
Every time I tell a patient they have coronary artery disease, their first response is usually:

“Can you get rid of it?”

My response:

Get rid of it completely?

No.

But....

/2
Can you potentially get the plaque to reduce in size, become more stable and potentially less likely to cause a heart attack?

Yes.

And that is a big deal.

/3
Read 23 tweets
Aug 16
A huge percentage of adults have a condition that seriously increases their risk of heart disease.

The problem is.... most don't even know they have it.

🧵👇

/1 Image
Insulin resistance is a core risk factor for the three leading causes of death:

- Cardiovascular Disease
- Cancer
- Dementia

Not the cause.

But a massive amplifier of risk.

/2 Image
Insulin resistance impacts up to 88% of adults depending on the studies you look at.

There are multiple ways to determine if you have insulin resistance.

Some are very accurate & complex.

Others are simple & fast to do.

Here's what those tests are from simple to complex

/3
Read 12 tweets
Aug 13
Between 40 - 60 years of age and want to know if you are at risk of a heart attack in the next 5 years?

Here are five things I would do. 👇
1. You cannot die from a condition you do not have.

Consider a Cardiac CT.

With no plaque present, your risk of a heart attack is <2% over the next 5 years.

There are no warranties or guarantees in medicine, but for near-term risk estimation, this is as good as it gets. Image
2. Check Your Lp(a)

Lp(a) is a modification to cholesterol particles that significantly increases your risk of coronary artery disease.

And stroke.

It's genetic & about 10-20% of the population have ⬆️ Lp(a)

⬆️ Lp(a) = ⬆️ Heart Disease Image
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(